DegronMD - Q5SXM2(SNAPC4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A1423D	TCGA-BR-8081	STAD	TCGA	DSGKCS	DEG_SCF_TRCP1_1	1432:1437	Mutation rewiring degron network	0.0833
p.A1423D	DO38795	STAD	ICGC	DSGKCS	DEG_SCF_TRCP1_1	1432:1437	Mutation rewiring degron network	0.0833
p.P1426L	TCGA-DF-A2KU	UCEC	TCGA	DSGKCS	DEG_SCF_TRCP1_1	1432:1437	Mutation rewiring degron network	0.1667
p.P1426L	DO223286	UCEC	ICGC	DSGKCS	DEG_SCF_TRCP1_1	1432:1437	Mutation rewiring degron network	0.1667
p.A1121V	TCGA-DX-AB37	SARC	TCGA	ALSSS	DEG_SPOP_SBC_1	1129:1133	Mutation rewiring degron network	0.1111
p.A1121V	DO220108	SARC	ICGC	ALSSS	DEG_SPOP_SBC_1	1129:1133	Mutation rewiring degron network	0.1111
p.M1140I	TCGA-ZF-AA4X	BLCA	TCGA	ALSSS	DEG_SPOP_SBC_1	1129:1133	Mutation rewiring degron network	0.1389
p.M1140I	DO219091	BLCA	ICGC	ALSSS	DEG_SPOP_SBC_1	1129:1133	Mutation rewiring degron network	0.1389
p.A1376S	DO48442	BLCA	ICGC	LAPQGVRTTLSV	DEG_ODPH_VHL_1	1381:1392	Mutation rewiring degron network	0.1944
p.D1432N	DO228431	BRCA	ICGC	DSGKCS	DEG_SCF_TRCP1_1	1432:1437	Mutation altering degron motif	0.6932
p.L1381Q	DO228581	GACA	ICGC	LAPQGVRTTLSV	DEG_ODPH_VHL_1	1381:1392	Mutation altering degron motif	0.7765
p.G1434R	DO233202	GACA	ICGC	DSGKCS	DEG_SCF_TRCP1_1	1432:1437	Mutation altering degron motif	0.7568
p.W1134C	DO15591	HNSC	ICGC	ALSSS	DEG_SPOP_SBC_1	1129:1133	Mutation rewiring degron network	0.3056
p.T1119N	DO228974	LICA	ICGC	ALSSS	DEG_SPOP_SBC_1	1129:1133	Mutation rewiring degron network	0.0556
p.D1447E	DO229019	LICA	ICGC	DSGKCS	DEG_SCF_TRCP1_1	1432:1437	Mutation rewiring degron network	0.0556
p.A1129T	DO23402	LINC	ICGC	ALSSS	DEG_SPOP_SBC_1	1129:1133	Mutation altering degron motif	0.7139
p.A1138V	DO230918	LUSC	ICGC	ALSSS	DEG_SPOP_SBC_1	1129:1133	Mutation rewiring degron network	0.1944
p.A1138V	DO224546	LUSC	ICGC	ALSSS	DEG_SPOP_SBC_1	1129:1133	Mutation rewiring degron network	0.1944
p.A1138S	DO230918	LUSC	ICGC	ALSSS	DEG_SPOP_SBC_1	1129:1133	Mutation rewiring degron network	0.1944
p.A1138S	DO224546	LUSC	ICGC	ALSSS	DEG_SPOP_SBC_1	1129:1133	Mutation rewiring degron network	0.1944
p.R1387C	DO229462	SKCA	ICGC	LAPQGVRTTLSV	DEG_ODPH_VHL_1	1381:1392	Mutation altering degron motif	0.719
p.S1132I	DO229240	THCA	ICGC	ALSSS	DEG_SPOP_SBC_1	1129:1133	Mutation altering degron motif	0.7341
p.Q1428E	SIDM01070	Non-Small Cell Lung Carcinoma	GDSC	DSGKCS	DEG_SCF_TRCP1_1	1432:1437	Mutation rewiring degron network	0.2222
p.Q1428E	ACH-000840	Lung Cancer	CCLE	DSGKCS	DEG_SCF_TRCP1_1	1432:1437	Mutation rewiring degron network	0.2222
p.Q1428E	HCC-366	lung	COSMIC	DSGKCS	DEG_SCF_TRCP1_1	1432:1437	Mutation rewiring degron network	0.2222
p.P1393H	SIDM01007	T-Lymphoblastic Leukemia	GDSC	LAPQGVRTTLSV	DEG_ODPH_VHL_1	1381:1392	Mutation rewiring degron network	0.3056
p.P1393H	ACH-002256	Leukemia	CCLE	LAPQGVRTTLSV	DEG_ODPH_VHL_1	1381:1392	Mutation rewiring degron network	0.3056
p.P1393H	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	LAPQGVRTTLSV	DEG_ODPH_VHL_1	1381:1392	Mutation rewiring degron network	0.3056
p.T1424A	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	DSGKCS	DEG_SCF_TRCP1_1	1432:1437	Mutation rewiring degron network	0.1111
p.T1424A	SIDM00720	Mesothelioma	GDSC	DSGKCS	DEG_SCF_TRCP1_1	1432:1437	Mutation rewiring degron network	0.1111
p.N1446D	SIDM00267	Biliary Tract Carcinoma	GDSC	DSGKCS	DEG_SCF_TRCP1_1	1432:1437	Mutation rewiring degron network	0.0833
p.N1446D	ACH-002312	Gallbladder Cancer	CCLE	DSGKCS	DEG_SCF_TRCP1_1	1432:1437	Mutation rewiring degron network	0.0833
p.N1446D	TGBC24TKB	biliary tract	COSMIC	DSGKCS	DEG_SCF_TRCP1_1	1432:1437	Mutation rewiring degron network	0.0833
p.P1137S	SIDM00878	Breast Carcinoma	GDSC	ALSSS	DEG_SPOP_SBC_1	1129:1133	Mutation rewiring degron network	0.2222
p.P1137S	ACH-000930	Breast Cancer	CCLE	ALSSS	DEG_SPOP_SBC_1	1129:1133	Mutation rewiring degron network	0.2222
p.P1137S	HCC1569	breast	COSMIC	ALSSS	DEG_SPOP_SBC_1	1129:1133	Mutation rewiring degron network	0.2222
p.A1129V	SIDM00391	Plasma Cell Myeloma	GDSC	ALSSS	DEG_SPOP_SBC_1	1129:1133	Mutation altering degron motif	0.5825
p.A1129V	ACH-000363	Myeloma	CCLE	ALSSS	DEG_SPOP_SBC_1	1129:1133	Mutation altering degron motif	0.5825
p.E1399Q	SIDM00272	Breast Carcinoma	GDSC	LAPQGVRTTLSV	DEG_ODPH_VHL_1	1381:1392	Mutation rewiring degron network	0.1389
p.E1399Q	ACH-000910	Breast Cancer	CCLE	LAPQGVRTTLSV	DEG_ODPH_VHL_1	1381:1392	Mutation rewiring degron network	0.1389
p.E1399Q	MDA-MB-453	breast	COSMIC	LAPQGVRTTLSV	DEG_ODPH_VHL_1	1381:1392	Mutation rewiring degron network	0.1389
p.T1388I	SIDM00516	Melanoma	GDSC	LAPQGVRTTLSV	DEG_ODPH_VHL_1	1381:1392	Mutation altering degron motif	0.5966
p.T1388I	MZ7-mel	skin	COSMIC	LAPQGVRTTLSV	DEG_ODPH_VHL_1	1381:1392	Mutation altering degron motif	0.5966
p.A1438T	SIDM00958	Chronic Myelogenous Leukemia	GDSC	DSGKCS	DEG_SCF_TRCP1_1	1432:1437	Mutation rewiring degron network	0.3056
p.A1438T	CML-T1	haematopoietic and lymphoid tissue	COSMIC	DSGKCS	DEG_SCF_TRCP1_1	1432:1437	Mutation rewiring degron network	0.3056
p.L1374P	ACH-000943	Colon/Colorectal Cancer	CCLE	LAPQGVRTTLSV	DEG_ODPH_VHL_1	1381:1392	Mutation rewiring degron network	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SNAPC4

UniProt ID: Q5SXM2

Entrez ID: 6621

Protein name: snRNA-activating protein complex subunit 4 (SNAPc subunit 4) (Proximal sequence element-binding transcription factor subunit alpha) (PSE-binding factor subunit alpha) (PTF subunit alpha) (snRNA-activating protein complex 190 kDa subunit) (SNAPc 190 kDa subunit)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SNAPC4 in