DegronMD

Uniprot ID: Q5SXM2

Source protein: snRNA-activating protein complex subunit 4

Source gene: SNAPC4

Class: DEG_SCF_TRCP1_1

Location: 1432:1437

E3 ligase: BTRC

DEGRON score: 0.7304

ASA_SCORE: 74.6167

COIL: 0.796

CONS_SCORE: 0.2845

DSS_SCORE: 0.3175

HELIX: 0.1357

FCONS_SCORE: 1.0463

RIG_SCORE: 0.6452

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1423D	TCGA-BR-8081	STAD	TCGA	DSGKCS	DEG_SCF_TRCP1_1	0.0833
p.A1423D	DO38795	STAD	ICGC	DSGKCS	DEG_SCF_TRCP1_1	0.0833
p.P1426L	TCGA-DF-A2KU	UCEC	TCGA	DSGKCS	DEG_SCF_TRCP1_1	0.1667
p.P1426L	DO223286	UCEC	ICGC	DSGKCS	DEG_SCF_TRCP1_1	0.1667
p.D1432N	DO228431	BRCA	ICGC	DSGKCS	DEG_SCF_TRCP1_1	0.6932
p.G1434R	DO233202	GACA	ICGC	DSGKCS	DEG_SCF_TRCP1_1	0.7568
p.D1447E	DO229019	LICA	ICGC	DSGKCS	DEG_SCF_TRCP1_1	0.0556
p.Q1428E	SIDM01070	Non-Small Cell Lung Carcinoma	GDSC	DSGKCS	DEG_SCF_TRCP1_1	0.2222
p.Q1428E	ACH-000840	Lung Cancer	CCLE	DSGKCS	DEG_SCF_TRCP1_1	0.2222
p.Q1428E	HCC-366	lung	COSMIC	DSGKCS	DEG_SCF_TRCP1_1	0.2222
p.T1424A	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	DSGKCS	DEG_SCF_TRCP1_1	0.1111
p.T1424A	SIDM00720	Mesothelioma	GDSC	DSGKCS	DEG_SCF_TRCP1_1	0.1111
p.N1446D	SIDM00267	Biliary Tract Carcinoma	GDSC	DSGKCS	DEG_SCF_TRCP1_1	0.0833
p.N1446D	ACH-002312	Gallbladder Cancer	CCLE	DSGKCS	DEG_SCF_TRCP1_1	0.0833
p.N1446D	TGBC24TKB	biliary_tract	COSMIC	DSGKCS	DEG_SCF_TRCP1_1	0.0833
p.A1438T	SIDM00958	Chronic Myelogenous Leukemia	GDSC	DSGKCS	DEG_SCF_TRCP1_1	0.3056
p.A1438T	CML-T1	haematopoietic_and_lymphoid_tissue	COSMIC	DSGKCS	DEG_SCF_TRCP1_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5SXM2	snRNA-activating protein complex subunit 4	DEG_SCF_TRCP1_1	1432:1437	DSGKCS	BTRC	0.7304	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons