DegronMD

Uniprot ID: Q5SXM2

Source protein: snRNA-activating protein complex subunit 4

Source gene: SNAPC4

Class: DEG_ODPH_VHL_1

Location: 1381:1392

E3 ligase: VHL

DEGRON score: 0.9852

ASA_SCORE: 73.4417

COIL: 0.7609

CONS_SCORE: 0.3178

DSS_SCORE: 0.2641

HELIX: 0.0359

FCONS_SCORE: 1.0302

RIG_SCORE: 0.7553

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1376S	DO48442	BLCA	ICGC	LAPQGVRTTLSV	DEG_ODPH_VHL_1	0.1944
p.L1381Q	DO228581	GACA	ICGC	LAPQGVRTTLSV	DEG_ODPH_VHL_1	0.7765
p.R1387C	DO229462	SKCA	ICGC	LAPQGVRTTLSV	DEG_ODPH_VHL_1	0.719
p.P1393H	SIDM01007	T-Lymphoblastic Leukemia	GDSC	LAPQGVRTTLSV	DEG_ODPH_VHL_1	0.3056
p.P1393H	ACH-002256	Leukemia	CCLE	LAPQGVRTTLSV	DEG_ODPH_VHL_1	0.3056
p.P1393H	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	LAPQGVRTTLSV	DEG_ODPH_VHL_1	0.3056
p.E1399Q	SIDM00272	Breast Carcinoma	GDSC	LAPQGVRTTLSV	DEG_ODPH_VHL_1	0.1389
p.E1399Q	ACH-000910	Breast Cancer	CCLE	LAPQGVRTTLSV	DEG_ODPH_VHL_1	0.1389
p.E1399Q	MDA-MB-453	breast	COSMIC	LAPQGVRTTLSV	DEG_ODPH_VHL_1	0.1389
p.T1388I	SIDM00516	Melanoma	GDSC	LAPQGVRTTLSV	DEG_ODPH_VHL_1	0.5966
p.T1388I	MZ7-mel	skin	COSMIC	LAPQGVRTTLSV	DEG_ODPH_VHL_1	0.5966
p.L1374P	ACH-000943	Colon/Colorectal Cancer	CCLE	LAPQGVRTTLSV	DEG_ODPH_VHL_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5SXM2	snRNA-activating protein complex subunit 4	DEG_ODPH_VHL_1	1381:1392	LAPQGVRTTLSV	VHL	0.9852	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons