DegronMD - Q9P242(NYAP2)

FUNCTION: Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis. {ECO:0000250}.

GO - Biological processes (BP): neuron projection morphogenesis [GO:0048812]; phosphatidylinositol 3-kinase signaling [GO:0014065]

GO - Molecular function (MF):

GO - Cellular component (CC):

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S413L	TCGA-FW-A3R5	SKCM	TCGA	ALSSS	DEG_SPOP_SBC_1	409:413	Mutation altering degron motif	0.8778
p.S413L	DO37406	SKCM	ICGC	ALSSS	DEG_SPOP_SBC_1	409:413	Mutation altering degron motif	0.8778
p.S413L	SIDM00975	Melanoma	GDSC	ALSSS	DEG_SPOP_SBC_1	409:413	Mutation altering degron motif	0.8778
p.S413L	ACH-002206	Skin Cancer	CCLE	ALSSS	DEG_SPOP_SBC_1	409:413	Mutation altering degron motif	0.8778
p.S413L	WM278	skin	COSMIC	ALSSS	DEG_SPOP_SBC_1	409:413	Mutation altering degron motif	0.8778
p.A409E	ACH-001955	Bone Cancer	CCLE	ALSSS	DEG_SPOP_SBC_1	409:413	Mutation altering degron motif	0.7701
p.S412L	TCGA-QF-A5YS	UCEC	TCGA	ALSSS	DEG_SPOP_SBC_1	409:413	Mutation altering degron motif	0.7667
p.S412L	DO52426	UCEC	ICGC	ALSSS	DEG_SPOP_SBC_1	409:413	Mutation altering degron motif	0.7667
p.D278N	TCGA-E6-A1LX	UCEC	TCGA	KYPIFDD	LIG_APCC_ABBAyCdc20_2	272:278	Mutation altering degron motif	0.6932
p.D278N	TCGA-EE-A2MD	SKCM	TCGA	KYPIFDD	LIG_APCC_ABBAyCdc20_2	272:278	Mutation altering degron motif	0.6932
p.D278N	TCGA-EE-A2MR	SKCM	TCGA	KYPIFDD	LIG_APCC_ABBAyCdc20_2	272:278	Mutation altering degron motif	0.6932
p.D278N	DO222434	MELA	ICGC	KYPIFDD	LIG_APCC_ABBAyCdc20_2	272:278	Mutation altering degron motif	0.6932
p.D278N	DO37851	SKCM	ICGC	KYPIFDD	LIG_APCC_ABBAyCdc20_2	272:278	Mutation altering degron motif	0.6932
p.D278N	DO37819	SKCM	ICGC	KYPIFDD	LIG_APCC_ABBAyCdc20_2	272:278	Mutation altering degron motif	0.6932
p.D278N	DO41020	UCEC	ICGC	KYPIFDD	LIG_APCC_ABBAyCdc20_2	272:278	Mutation altering degron motif	0.6932
p.S462L	TCGA-AA-A00N	COAD	TCGA	PPPY	ITCH	454:457	Mutation blocking phosphorylation signal	0.6389
p.S462L	TCGA-B5-A3FA	UCEC	TCGA	PPPY	ITCH	454:457	Mutation blocking phosphorylation signal	0.6389
p.S462L	TCGA-CM-6164	COAD	TCGA	PPPY	ITCH	454:457	Mutation blocking phosphorylation signal	0.6389
p.S462L	DO7930	COAD	ICGC	PPPY	ITCH	454:457	Mutation blocking phosphorylation signal	0.6389
p.S462L	DO9876	COAD	ICGC	PPPY	ITCH	454:457	Mutation blocking phosphorylation signal	0.6389

Showing 1 to 20 of 150 entries

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No resistance data available for this Degron.

Kaplan plot for NYAP2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NYAP2

UniProt ID: Q9P242

Entrez ID: 57624

Protein name: Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2

External links: UniprotKB HGNC RefSeq COSMIC

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No resistance data available for this Degron.

Kaplan plot for NYAP2 in