DegronMD - Q9P242(NYAP2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A409V	TCGA-2W-A8YY	CESC	TCGA	ALSSS	DEG_SPOP_SBC_1	409:413	Mutation altering degron motif	0.5825
p.A409V	TCGA-D1-A2G0	UCEC	TCGA	ALSSS	DEG_SPOP_SBC_1	409:413	Mutation altering degron motif	0.5825
p.A409V	DO223732	CESC	ICGC	ALSSS	DEG_SPOP_SBC_1	409:413	Mutation altering degron motif	0.5825
p.A409V	DO233109	GACA	ICGC	ALSSS	DEG_SPOP_SBC_1	409:413	Mutation altering degron motif	0.5825
p.A409V	DO43049	UCEC	ICGC	ALSSS	DEG_SPOP_SBC_1	409:413	Mutation altering degron motif	0.5825
p.A577S	TCGA-2W-A8YY	CESC	TCGA	PGTPVVT	DEG_SCF_FBW7_1	584:590	Mutation rewiring degron network	0.1389
p.A459T	TCGA-34-5929	LUSC	TCGA	PPPY	ITCH	454:457	Mutation rewiring degron network	0.2778
p.A459T	TCGA-AG-3894	READ	TCGA	PPPY	ITCH	454:457	Mutation rewiring degron network	0.2778
p.A459T	TCGA-EO-A3KX	UCEC	TCGA	PPPY	ITCH	454:457	Mutation rewiring degron network	0.2778
p.A459T	DO234382	ESAD	ICGC	PPPY	ITCH	454:457	Mutation rewiring degron network	0.2778
p.A459T	DO26659	LUSC	ICGC	PPPY	ITCH	454:457	Mutation rewiring degron network	0.2778
p.A459T	DO36419	READ	ICGC	PPPY	ITCH	454:457	Mutation rewiring degron network	0.2778
p.A459T	DO219774	UCEC	ICGC	PPPY	ITCH	454:457	Mutation rewiring degron network	0.2778
p.L279V	TCGA-37-3789	LUSC	TCGA	KYPIFDD	LIG_APCC_ABBAyCdc20_2	272:278	Mutation rewiring degron network	0.3056
p.L279V	DO26743	LUSC	ICGC	KYPIFDD	LIG_APCC_ABBAyCdc20_2	272:278	Mutation rewiring degron network	0.3056
p.A283T	TCGA-AA-3672	COAD	TCGA	KYPIFDD	LIG_APCC_ABBAyCdc20_2	272:278	Mutation rewiring degron network	0.1944
p.A283T	DO9010	COAD	ICGC	KYPIFDD	LIG_APCC_ABBAyCdc20_2	272:278	Mutation rewiring degron network	0.1944
p.A283T	DO233259	GACA	ICGC	KYPIFDD	LIG_APCC_ABBAyCdc20_2	272:278	Mutation rewiring degron network	0.1944
p.A283T	SIDM02041	Colorectal Carcinoma	GDSC	KYPIFDD	LIG_APCC_ABBAyCdc20_2	272:278	Mutation rewiring degron network	0.1944
p.A399V	TCGA-AA-3971	COAD	TCGA	ALSSS	DEG_SPOP_SBC_1	409:413	Mutation rewiring degron network	0.0556
p.A399V	DO7825	COAD	ICGC	ALSSS	DEG_SPOP_SBC_1	409:413	Mutation rewiring degron network	0.0556
p.A399V	DO231788	LINC	ICGC	ALSSS	DEG_SPOP_SBC_1	409:413	Mutation rewiring degron network	0.0556
p.S462L	TCGA-AA-A00N	COAD	TCGA	PPPY	ITCH	454:457	Mutation blocking phosphorylation signal	0.6389
p.S462L	TCGA-B5-A3FA	UCEC	TCGA	PPPY	ITCH	454:457	Mutation blocking phosphorylation signal	0.6389
p.S462L	TCGA-CM-6164	COAD	TCGA	PPPY	ITCH	454:457	Mutation blocking phosphorylation signal	0.6389
p.S462L	DO7930	COAD	ICGC	PPPY	ITCH	454:457	Mutation blocking phosphorylation signal	0.6389
p.S462L	DO9876	COAD	ICGC	PPPY	ITCH	454:457	Mutation blocking phosphorylation signal	0.6389
p.S462L	DO10858	ESAD	ICGC	PPPY	ITCH	454:457	Mutation blocking phosphorylation signal	0.6389
p.S462L	DO233260	GACA	ICGC	PPPY	ITCH	454:457	Mutation blocking phosphorylation signal	0.6389
p.S462L	DO52402	UCEC	ICGC	PPPY	ITCH	454:457	Mutation blocking phosphorylation signal	0.6389
p.A283V	TCGA-AA-A010	COAD	TCGA	KYPIFDD	LIG_APCC_ABBAyCdc20_2	272:278	Mutation rewiring degron network	0.1944
p.S464N	TCGA-AX-A06F	UCEC	TCGA	PPPY	ITCH	454:457	Mutation rewiring degron network	0.1389
p.S464N	DO41752	UCEC	ICGC	PPPY	ITCH	454:457	Mutation rewiring degron network	0.1389
p.T419M	TCGA-AZ-4681	COAD	TCGA	ALSSS	DEG_SPOP_SBC_1	409:413	Mutation rewiring degron network	0.1667
p.T419M	DO9306	COAD	ICGC	ALSSS	DEG_SPOP_SBC_1	409:413	Mutation rewiring degron network	0.1667
p.T419M	DO233828	GACA	ICGC	ALSSS	DEG_SPOP_SBC_1	409:413	Mutation rewiring degron network	0.1667
p.T419M	DO50696	ORCA	ICGC	ALSSS	DEG_SPOP_SBC_1	409:413	Mutation rewiring degron network	0.1667
p.T419M	DO49149	PACA	ICGC	ALSSS	DEG_SPOP_SBC_1	409:413	Mutation rewiring degron network	0.1667
p.D288N	TCGA-B5-A1MR	UCEC	TCGA	KYPIFDD	LIG_APCC_ABBAyCdc20_2	272:278	Mutation rewiring degron network	0.0556
p.D288N	DO41758	UCEC	ICGC	KYPIFDD	LIG_APCC_ABBAyCdc20_2	272:278	Mutation rewiring degron network	0.0556
p.S464R	TCGA-BP-4782	KIRC	TCGA	PPPY	ITCH	454:457	Mutation rewiring degron network	0.1389
p.S464R	DO19653	KIRC	ICGC	PPPY	ITCH	454:457	Mutation rewiring degron network	0.1389
p.L465V	TCGA-BP-4782	KIRC	TCGA	PPPY	ITCH	454:457	Mutation rewiring degron network	0.1111
p.L465V	DO19653	KIRC	ICGC	PPPY	ITCH	454:457	Mutation rewiring degron network	0.1111
p.T423A	TCGA-BR-4361	STAD	TCGA	ALSSS	DEG_SPOP_SBC_1	409:413	Mutation rewiring degron network	0.0556
p.T423A	DO38887	STAD	ICGC	ALSSS	DEG_SPOP_SBC_1	409:413	Mutation rewiring degron network	0.0556
p.K452E	TCGA-BS-A0UV	UCEC	TCGA	PPPY	ITCH	454:457	Mutation rewiring degron network	0.2778
p.K452E	DO42793	UCEC	ICGC	PPPY	ITCH	454:457	Mutation rewiring degron network	0.2778
p.G402R	TCGA-BT-A42C	BLCA	TCGA	ALSSS	DEG_SPOP_SBC_1	409:413	Mutation rewiring degron network	0.1389
p.G402R	DO49725	BLCA	ICGC	ALSSS	DEG_SPOP_SBC_1	409:413	Mutation rewiring degron network	0.1389
p.R592Q	TCGA-CA-6717	COAD	TCGA	PGTPVVT	DEG_SCF_FBW7_1	584:590	Mutation rewiring degron network	0.2778
p.R592Q	DO8264	COAD	ICGC	PGTPVVT	DEG_SCF_FBW7_1	584:590	Mutation rewiring degron network	0.2778
p.R592Q	DO50321	ESAD	ICGC	PGTPVVT	DEG_SCF_FBW7_1	584:590	Mutation rewiring degron network	0.2778
p.R592Q	SIDM00192	Colorectal Carcinoma	GDSC	PGTPVVT	DEG_SCF_FBW7_1	584:590	Mutation rewiring degron network	0.2778
p.R592Q	ACH-000286	Colon/Colorectal Cancer	CCLE	PGTPVVT	DEG_SCF_FBW7_1	584:590	Mutation rewiring degron network	0.2778
p.L449R	TCGA-CN-A641	HNSC	TCGA	PPPY	ITCH	454:457	Mutation rewiring degron network	0.1944
p.L449R	DO44436	HNSC	ICGC	PPPY	ITCH	454:457	Mutation rewiring degron network	0.1944
p.R444M	TCGA-CV-7424	HNSC	TCGA	PPPY	ITCH	454:457	Mutation rewiring degron network	0.0556
p.R444M	DO14998	HNSC	ICGC	PPPY	ITCH	454:457	Mutation rewiring degron network	0.0556
p.R444M	ACH-001336	Cervical Cancer	CCLE	PPPY	ITCH	454:457	Mutation rewiring degron network	0.0556
p.L279F	TCGA-CV-A461	HNSC	TCGA	KYPIFDD	LIG_APCC_ABBAyCdc20_2	272:278	Mutation rewiring degron network	0.3056
p.L279F	DO49058	HNSC	ICGC	KYPIFDD	LIG_APCC_ABBAyCdc20_2	272:278	Mutation rewiring degron network	0.3056
p.Y273C	TCGA-D1-A15X	UCEC	TCGA	KYPIFDD	LIG_APCC_ABBAyCdc20_2	272:278	Mutation altering degron motif	0.5976
p.Y273C	DO43274	UCEC	ICGC	KYPIFDD	LIG_APCC_ABBAyCdc20_2	272:278	Mutation altering degron motif	0.5976
p.K576E	TCGA-D1-A16Y	UCEC	TCGA	PGTPVVT	DEG_SCF_FBW7_1	584:590	Mutation substituting flanking lysine	0.2222
p.K576E	SIDM01045	Endometrial Carcinoma	GDSC	PGTPVVT	DEG_SCF_FBW7_1	584:590	Mutation substituting flanking lysine	0.2222
p.K576E	ACH-000978	Endometrial/Uterine Cancer	CCLE	PGTPVVT	DEG_SCF_FBW7_1	584:590	Mutation substituting flanking lysine	0.2222
p.K576E	EN	endometrium	COSMIC	PGTPVVT	DEG_SCF_FBW7_1	584:590	Mutation substituting flanking lysine	0.2222
p.V589I	TCGA-D1-A17H	UCEC	TCGA	PGTPVVT	DEG_SCF_FBW7_1	584:590	Mutation altering degron motif	0.5965
p.D458N	TCGA-D5-6932	COAD	TCGA	PPPY	ITCH	454:457	Mutation rewiring degron network	0.3056
p.D458N	TCGA-ER-A19H	SKCM	TCGA	PPPY	ITCH	454:457	Mutation rewiring degron network	0.3056
p.D458N	DO9378	COAD	ICGC	PPPY	ITCH	454:457	Mutation rewiring degron network	0.3056
p.D458N	DO233652	GACA	ICGC	PPPY	ITCH	454:457	Mutation rewiring degron network	0.3056
p.D458N	DO222875	MELA	ICGC	PPPY	ITCH	454:457	Mutation rewiring degron network	0.3056
p.D458N	DO47299	SKCM	ICGC	PPPY	ITCH	454:457	Mutation rewiring degron network	0.3056
p.D278N	TCGA-E6-A1LX	UCEC	TCGA	KYPIFDD	LIG_APCC_ABBAyCdc20_2	272:278	Mutation altering degron motif	0.6932
p.D278N	TCGA-EE-A2MD	SKCM	TCGA	KYPIFDD	LIG_APCC_ABBAyCdc20_2	272:278	Mutation altering degron motif	0.6932
p.D278N	TCGA-EE-A2MR	SKCM	TCGA	KYPIFDD	LIG_APCC_ABBAyCdc20_2	272:278	Mutation altering degron motif	0.6932
p.D278N	DO222434	MELA	ICGC	KYPIFDD	LIG_APCC_ABBAyCdc20_2	272:278	Mutation altering degron motif	0.6932
p.D278N	DO37851	SKCM	ICGC	KYPIFDD	LIG_APCC_ABBAyCdc20_2	272:278	Mutation altering degron motif	0.6932
p.D278N	DO37819	SKCM	ICGC	KYPIFDD	LIG_APCC_ABBAyCdc20_2	272:278	Mutation altering degron motif	0.6932
p.D278N	DO41020	UCEC	ICGC	KYPIFDD	LIG_APCC_ABBAyCdc20_2	272:278	Mutation altering degron motif	0.6932
p.P448L	TCGA-EE-A185	SKCM	TCGA	PPPY	ITCH	454:457	Mutation rewiring degron network	0.1667
p.P448L	DO222658	MELA	ICGC	PPPY	ITCH	454:457	Mutation rewiring degron network	0.1667
p.P448L	DO37599	SKCM	ICGC	PPPY	ITCH	454:457	Mutation rewiring degron network	0.1667
p.E270A	TCGA-EE-A3J7	SKCM	TCGA	KYPIFDD	LIG_APCC_ABBAyCdc20_2	272:278	Mutation rewiring degron network	0.2778
p.E270A	DO48770	SKCM	ICGC	KYPIFDD	LIG_APCC_ABBAyCdc20_2	272:278	Mutation rewiring degron network	0.2778
p.P403A	TCGA-FF-A7CR	DLBC	TCGA	ALSSS	DEG_SPOP_SBC_1	409:413	Mutation rewiring degron network	0.1667
p.P403A	DO219894	DLBC	ICGC	ALSSS	DEG_SPOP_SBC_1	409:413	Mutation rewiring degron network	0.1667
p.R422Q	TCGA-FR-A726	SKCM	TCGA	ALSSS	DEG_SPOP_SBC_1	409:413	Mutation rewiring degron network	0.0833
p.R422Q	DO230312	COCA	ICGC	ALSSS	DEG_SPOP_SBC_1	409:413	Mutation rewiring degron network	0.0833
p.R422Q	DO222762	COCA	ICGC	ALSSS	DEG_SPOP_SBC_1	409:413	Mutation rewiring degron network	0.0833
p.R422Q	DO222418	MELA	ICGC	ALSSS	DEG_SPOP_SBC_1	409:413	Mutation rewiring degron network	0.0833
p.R422Q	DO48665	SKCM	ICGC	ALSSS	DEG_SPOP_SBC_1	409:413	Mutation rewiring degron network	0.0833
p.R422Q	SIDM00737	Non-Small Cell Lung Carcinoma	GDSC	ALSSS	DEG_SPOP_SBC_1	409:413	Mutation rewiring degron network	0.0833
p.R422Q	ACH-001362	Lung Cancer	CCLE	ALSSS	DEG_SPOP_SBC_1	409:413	Mutation rewiring degron network	0.0833
p.R422Q	NCI-H1770	lung	COSMIC	ALSSS	DEG_SPOP_SBC_1	409:413	Mutation rewiring degron network	0.0833
p.S413L	TCGA-FW-A3R5	SKCM	TCGA	ALSSS	DEG_SPOP_SBC_1	409:413	Mutation altering degron motif	0.8778
p.S413L	DO37406	SKCM	ICGC	ALSSS	DEG_SPOP_SBC_1	409:413	Mutation altering degron motif	0.8778
p.S413L	SIDM00975	Melanoma	GDSC	ALSSS	DEG_SPOP_SBC_1	409:413	Mutation altering degron motif	0.8778
p.S413L	ACH-002206	Skin Cancer	CCLE	ALSSS	DEG_SPOP_SBC_1	409:413	Mutation altering degron motif	0.8778
p.S413L	WM278	skin	COSMIC	ALSSS	DEG_SPOP_SBC_1	409:413	Mutation altering degron motif	0.8778
p.R453G	TCGA-JY-A6FA	ESCA	TCGA	PPPY	ITCH	454:457	Mutation rewiring degron network	0.3056
p.S412L	TCGA-QF-A5YS	UCEC	TCGA	ALSSS	DEG_SPOP_SBC_1	409:413	Mutation altering degron motif	0.7667
p.S412L	DO52426	UCEC	ICGC	ALSSS	DEG_SPOP_SBC_1	409:413	Mutation altering degron motif	0.7667
p.A399T	DO222468	BTCA	ICGC	ALSSS	DEG_SPOP_SBC_1	409:413	Mutation rewiring degron network	0.0556
p.A399T	SIDM00490	Glioma	GDSC	ALSSS	DEG_SPOP_SBC_1	409:413	Mutation rewiring degron network	0.0556
p.A399T	ACH-001016	Brain Cancer	CCLE	ALSSS	DEG_SPOP_SBC_1	409:413	Mutation rewiring degron network	0.0556
p.A399T	Becker	central nervous system	COSMIC	ALSSS	DEG_SPOP_SBC_1	409:413	Mutation rewiring degron network	0.0556
p.Q263H	DO222884	COCA	ICGC	KYPIFDD	LIG_APCC_ABBAyCdc20_2	272:278	Mutation rewiring degron network	0.0833
p.L420M	DO233254	GACA	ICGC	ALSSS	DEG_SPOP_SBC_1	409:413	Mutation rewiring degron network	0.1389
p.S264C	DO233702	GACA	ICGC	KYPIFDD	LIG_APCC_ABBAyCdc20_2	272:278	Mutation rewiring degron network	0.1111
p.D282H	DO233897	GACA	ICGC	KYPIFDD	LIG_APCC_ABBAyCdc20_2	272:278	Mutation rewiring degron network	0.2222
p.G280V	DO228938	LICA	ICGC	KYPIFDD	LIG_APCC_ABBAyCdc20_2	272:278	Mutation rewiring degron network	0.2778
p.P456T	DO23174	LINC	ICGC	PPPY	ITCH	454:457	Mutation altering degron motif	0.5919
p.P456T	SIDM01044	Other Solid Cancers	GDSC	PPPY	ITCH	454:457	Mutation altering degron motif	0.5919
p.P456T	ACH-000585	Lung Cancer	CCLE	PPPY	ITCH	454:457	Mutation altering degron motif	0.5919
p.P456T	EPLC-272H	lung	COSMIC	PPPY	ITCH	454:457	Mutation altering degron motif	0.5919
p.S264N	DO228291	MALY	ICGC	KYPIFDD	LIG_APCC_ABBAyCdc20_2	272:278	Mutation rewiring degron network	0.1111
p.P448F	DO222595	MELA	ICGC	PPPY	ITCH	454:457	Mutation rewiring degron network	0.1667
p.G402V	DO50723	ORCA	ICGC	ALSSS	DEG_SPOP_SBC_1	409:413	Mutation rewiring degron network	0.1389
p.G402V	SIDM00841	Colorectal Carcinoma	GDSC	ALSSS	DEG_SPOP_SBC_1	409:413	Mutation rewiring degron network	0.1389
p.G402V	ACH-000651	Colon/Colorectal Cancer	CCLE	ALSSS	DEG_SPOP_SBC_1	409:413	Mutation rewiring degron network	0.1389
p.G402V	ACH-000842	Colon/Colorectal Cancer	CCLE	ALSSS	DEG_SPOP_SBC_1	409:413	Mutation rewiring degron network	0.1389
p.G402V	SW620	large intestine	COSMIC	ALSSS	DEG_SPOP_SBC_1	409:413	Mutation rewiring degron network	0.1389
p.L465I	DO33004	PACA	ICGC	PPPY	ITCH	454:457	Mutation rewiring degron network	0.1111
p.Q263E	DO32916	PACA	ICGC	KYPIFDD	LIG_APCC_ABBAyCdc20_2	272:278	Mutation rewiring degron network	0.0833
p.A266T	DO38404	STAD	ICGC	KYPIFDD	LIG_APCC_ABBAyCdc20_2	272:278	Mutation rewiring degron network	0.1667
p.P417L	SIDM00545	Melanoma	GDSC	ALSSS	DEG_SPOP_SBC_1	409:413	Mutation rewiring degron network	0.2222
p.P417L	Mewo	skin	COSMIC	ALSSS	DEG_SPOP_SBC_1	409:413	Mutation rewiring degron network	0.2222
p.G402E	SIDM01175	Other Sarcomas	GDSC	ALSSS	DEG_SPOP_SBC_1	409:413	Mutation rewiring degron network	0.1389
p.G402E	ACH-002309	Sarcoma	CCLE	ALSSS	DEG_SPOP_SBC_1	409:413	Mutation rewiring degron network	0.1389
p.G402E	SW684	soft tissue	COSMIC	ALSSS	DEG_SPOP_SBC_1	409:413	Mutation rewiring degron network	0.1389
p.D288E	SIDM00687	Gastric Carcinoma	GDSC	KYPIFDD	LIG_APCC_ABBAyCdc20_2	272:278	Mutation rewiring degron network	0.0556
p.D288E	ACH-000793	Gastric Cancer	CCLE	KYPIFDD	LIG_APCC_ABBAyCdc20_2	272:278	Mutation rewiring degron network	0.0556
p.D288E	KATOIII	stomach	COSMIC	KYPIFDD	LIG_APCC_ABBAyCdc20_2	272:278	Mutation rewiring degron network	0.0556
p.E270K	SIDM00003	Melanoma	GDSC	KYPIFDD	LIG_APCC_ABBAyCdc20_2	272:278	Mutation rewiring degron network	0.2778
p.E270K	ACH-000884	Skin Cancer	CCLE	KYPIFDD	LIG_APCC_ABBAyCdc20_2	272:278	Mutation rewiring degron network	0.2778
p.E270K	ACH-002159	Skin Cancer	CCLE	KYPIFDD	LIG_APCC_ABBAyCdc20_2	272:278	Mutation rewiring degron network	0.2778
p.E270K	M14	skin	COSMIC	KYPIFDD	LIG_APCC_ABBAyCdc20_2	272:278	Mutation rewiring degron network	0.2778
p.R453S	SIDM00050	Chondrosarcoma	GDSC	PPPY	ITCH	454:457	Mutation rewiring degron network	0.3056
p.R453S	ACH-002093	Bone Cancer	CCLE	PPPY	ITCH	454:457	Mutation rewiring degron network	0.3056
p.R453S	CHSA0108	bone	COSMIC	PPPY	ITCH	454:457	Mutation rewiring degron network	0.3056
p.R444K	SIDM00140	Melanoma	GDSC	PPPY	ITCH	454:457	Mutation rewiring degron network	0.0556
p.R444K	ACH-000968	Skin Cancer	CCLE	PPPY	ITCH	454:457	Mutation rewiring degron network	0.0556
p.R444K	COLO-792	skin	COSMIC	PPPY	ITCH	454:457	Mutation rewiring degron network	0.0556
p.V575D	SIDM00591	Oral Cavity Carcinoma	GDSC	PGTPVVT	DEG_SCF_FBW7_1	584:590	Mutation rewiring degron network	0.0833
p.V575D	ACH-002045	Head and Neck Cancer	CCLE	PGTPVVT	DEG_SCF_FBW7_1	584:590	Mutation rewiring degron network	0.0833
p.V575D	HO-1-u-1	upper aerodigestive tract	COSMIC	PGTPVVT	DEG_SCF_FBW7_1	584:590	Mutation rewiring degron network	0.0833
p.A409E	ACH-001955	Bone Cancer	CCLE	ALSSS	DEG_SPOP_SBC_1	409:413	Mutation altering degron motif	0.7701

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NYAP2

UniProt ID: Q9P242

Entrez ID: 57624

Protein name: Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NYAP2 in