DegronMD

Uniprot ID: Q9P242

Source protein: Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2

Source gene: NYAP2

Class: DEG_SCF_FBW7_1

Location: 584:590

E3 ligase: FBXW7

DEGRON score: 0.9891

ASA_SCORE: 72.7286

COIL: 0.8544

CONS_SCORE: 0.3371

DSS_SCORE: 0.5353

HELIX: 0.0219

FCONS_SCORE: 0.9507

RIG_SCORE: 0.71

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A577S	TCGA-2W-A8YY	CESC	TCGA	PGTPVVT	DEG_SCF_FBW7_1	0.1389
p.R592Q	TCGA-CA-6717	COAD	TCGA	PGTPVVT	DEG_SCF_FBW7_1	0.2778
p.R592Q	DO8264	COAD	ICGC	PGTPVVT	DEG_SCF_FBW7_1	0.2778
p.R592Q	DO50321	ESAD	ICGC	PGTPVVT	DEG_SCF_FBW7_1	0.2778
p.R592Q	SIDM00192	Colorectal Carcinoma	GDSC	PGTPVVT	DEG_SCF_FBW7_1	0.2778
p.R592Q	ACH-000286	Colon/Colorectal Cancer	CCLE	PGTPVVT	DEG_SCF_FBW7_1	0.2778
p.K576E	TCGA-D1-A16Y	UCEC	TCGA	PGTPVVT	DEG_SCF_FBW7_1	0.2222
p.K576E	SIDM01045	Endometrial Carcinoma	GDSC	PGTPVVT	DEG_SCF_FBW7_1	0.2222
p.K576E	ACH-000978	Endometrial/Uterine Cancer	CCLE	PGTPVVT	DEG_SCF_FBW7_1	0.2222
p.K576E	EN	endometrium	COSMIC	PGTPVVT	DEG_SCF_FBW7_1	0.2222
p.V589I	TCGA-D1-A17H	UCEC	TCGA	PGTPVVT	DEG_SCF_FBW7_1	0.5965
p.V575D	SIDM00591	Oral Cavity Carcinoma	GDSC	PGTPVVT	DEG_SCF_FBW7_1	0.0833
p.V575D	ACH-002045	Head and Neck Cancer	CCLE	PGTPVVT	DEG_SCF_FBW7_1	0.0833
p.V575D	HO-1-u-1	upper_aerodigestive_tract	COSMIC	PGTPVVT	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P242	Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2	DEG_SCF_FBW7_1	584:590	PGTPVVT	FBXW7	0.9891	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons