DegronMD

Uniprot ID: Q9P242

Source protein: Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2

Source gene: NYAP2

Class: LIG_APCC_ABBAyCdc20_2

Location: 272:278

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5468

ASA_SCORE: 68.5429

COIL: 0.6864

CONS_SCORE: 0.7621

DSS_SCORE: 0.3235

HELIX: 0.2277

FCONS_SCORE: 1.1904

RIG_SCORE: 0.8423

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L279V	TCGA-37-3789	LUSC	TCGA	KYPIFDD	LIG_APCC_ABBAyCdc20_2	0.3056
p.L279V	DO26743	LUSC	ICGC	KYPIFDD	LIG_APCC_ABBAyCdc20_2	0.3056
p.A283T	TCGA-AA-3672	COAD	TCGA	KYPIFDD	LIG_APCC_ABBAyCdc20_2	0.1944
p.A283T	DO9010	COAD	ICGC	KYPIFDD	LIG_APCC_ABBAyCdc20_2	0.1944
p.A283T	DO233259	GACA	ICGC	KYPIFDD	LIG_APCC_ABBAyCdc20_2	0.1944
p.A283T	SIDM02041	Colorectal Carcinoma	GDSC	KYPIFDD	LIG_APCC_ABBAyCdc20_2	0.1944
p.A283V	TCGA-AA-A010	COAD	TCGA	KYPIFDD	LIG_APCC_ABBAyCdc20_2	0.1944
p.D288N	TCGA-B5-A1MR	UCEC	TCGA	KYPIFDD	LIG_APCC_ABBAyCdc20_2	0.0556
p.D288N	DO41758	UCEC	ICGC	KYPIFDD	LIG_APCC_ABBAyCdc20_2	0.0556
p.L279F	TCGA-CV-A461	HNSC	TCGA	KYPIFDD	LIG_APCC_ABBAyCdc20_2	0.3056
p.L279F	DO49058	HNSC	ICGC	KYPIFDD	LIG_APCC_ABBAyCdc20_2	0.3056
p.Y273C	TCGA-D1-A15X	UCEC	TCGA	KYPIFDD	LIG_APCC_ABBAyCdc20_2	0.5976
p.Y273C	DO43274	UCEC	ICGC	KYPIFDD	LIG_APCC_ABBAyCdc20_2	0.5976
p.D278N	TCGA-E6-A1LX	UCEC	TCGA	KYPIFDD	LIG_APCC_ABBAyCdc20_2	0.6932
p.D278N	TCGA-EE-A2MD	SKCM	TCGA	KYPIFDD	LIG_APCC_ABBAyCdc20_2	0.6932
p.D278N	TCGA-EE-A2MR	SKCM	TCGA	KYPIFDD	LIG_APCC_ABBAyCdc20_2	0.6932
p.D278N	DO222434	MELA	ICGC	KYPIFDD	LIG_APCC_ABBAyCdc20_2	0.6932
p.D278N	DO37851	SKCM	ICGC	KYPIFDD	LIG_APCC_ABBAyCdc20_2	0.6932
p.D278N	DO37819	SKCM	ICGC	KYPIFDD	LIG_APCC_ABBAyCdc20_2	0.6932
p.D278N	DO41020	UCEC	ICGC	KYPIFDD	LIG_APCC_ABBAyCdc20_2	0.6932
p.E270A	TCGA-EE-A3J7	SKCM	TCGA	KYPIFDD	LIG_APCC_ABBAyCdc20_2	0.2778
p.E270A	DO48770	SKCM	ICGC	KYPIFDD	LIG_APCC_ABBAyCdc20_2	0.2778
p.Q263H	DO222884	COCA	ICGC	KYPIFDD	LIG_APCC_ABBAyCdc20_2	0.0833
p.S264C	DO233702	GACA	ICGC	KYPIFDD	LIG_APCC_ABBAyCdc20_2	0.1111
p.D282H	DO233897	GACA	ICGC	KYPIFDD	LIG_APCC_ABBAyCdc20_2	0.2222
p.G280V	DO228938	LICA	ICGC	KYPIFDD	LIG_APCC_ABBAyCdc20_2	0.2778
p.S264N	DO228291	MALY	ICGC	KYPIFDD	LIG_APCC_ABBAyCdc20_2	0.1111
p.Q263E	DO32916	PACA	ICGC	KYPIFDD	LIG_APCC_ABBAyCdc20_2	0.0833
p.A266T	DO38404	STAD	ICGC	KYPIFDD	LIG_APCC_ABBAyCdc20_2	0.1667
p.D288E	SIDM00687	Gastric Carcinoma	GDSC	KYPIFDD	LIG_APCC_ABBAyCdc20_2	0.0556
p.D288E	ACH-000793	Gastric Cancer	CCLE	KYPIFDD	LIG_APCC_ABBAyCdc20_2	0.0556
p.D288E	KATOIII	stomach	COSMIC	KYPIFDD	LIG_APCC_ABBAyCdc20_2	0.0556
p.E270K	SIDM00003	Melanoma	GDSC	KYPIFDD	LIG_APCC_ABBAyCdc20_2	0.2778
p.E270K	ACH-000884	Skin Cancer	CCLE	KYPIFDD	LIG_APCC_ABBAyCdc20_2	0.2778
p.E270K	ACH-002159	Skin Cancer	CCLE	KYPIFDD	LIG_APCC_ABBAyCdc20_2	0.2778
p.E270K	M14	skin	COSMIC	KYPIFDD	LIG_APCC_ABBAyCdc20_2	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KYPIFDD

Degron related mutations and impact score

Drug responses associated with NYAP2 mutations

All proteins holding degron of KYPIFDD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P242	Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2	LIG_APCC_ABBAyCdc20_2	272:278	KYPIFDD	APC,CDC20,FZR1	0.5468	More...