DegronMD - Q13342(SP140)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S183N	TCGA-2W-A8YY	CESC	TCGA	ALSSS	DEG_SPOP_SBC_1	181:185	Mutation altering degron motif	0.7069
p.S183N	DO223732	CESC	ICGC	ALSSS	DEG_SPOP_SBC_1	181:185	Mutation altering degron motif	0.7069
p.A358S	TCGA-34-5241	LUSC	TCGA	LKTPQVT	DEG_SCF_FBW7_1	363:369	Mutation rewiring degron network	0.1944
p.M172I	TCGA-49-AARQ	LUAD	TCGA	ALSSS	DEG_SPOP_SBC_1	181:185	Mutation rewiring degron network	0.0833
p.M172I	DO229019	LICA	ICGC	ALSSS	DEG_SPOP_SBC_1	181:185	Mutation rewiring degron network	0.0833
p.M172I	DO51189	LUAD	ICGC	ALSSS	DEG_SPOP_SBC_1	181:185	Mutation rewiring degron network	0.0833
p.L182F	TCGA-5L-AAT1	BRCA	TCGA	ALSSS	DEG_SPOP_SBC_1	181:185	Mutation altering degron motif	0.587
p.L182F	DO219594	BRCA	ICGC	ALSSS	DEG_SPOP_SBC_1	181:185	Mutation altering degron motif	0.587
p.A258S	TCGA-A6-2677	COAD	TCGA	DAARTYSTAP	CBL_PTK	256:265	Mutation altering degron motif	0.6477
p.A257V	TCGA-AP-A0LM	UCEC	TCGA	DAARTYSTAP	CBL_PTK	256:265	Mutation altering degron motif	0.5825
p.A257V	SIDM00451	T-Lymphoblastic Leukemia	GDSC	DAARTYSTAP	CBL_PTK	256:265	Mutation altering degron motif	0.5825
p.A257V	PF-382	haematopoietic and lymphoid tissue	COSMIC	DAARTYSTAP	CBL_PTK	256:265	Mutation altering degron motif	0.5825
p.D296G	TCGA-AX-A1CE	UCEC	TCGA	LKTPQVT	DEG_SCF_FBW7_1	302:308	Mutation rewiring degron network	0.1667
p.V307F	TCGA-AX-A2HC	UCEC	TCGA	LKTPQVT	DEG_SCF_FBW7_1	302:308	Mutation altering degron motif	0.5957
p.Y261C	TCGA-BG-A0LX	UCEC	TCGA	DAARTYSTAP	CBL_PTK	256:265	Mutation altering degron motif	0.7087
p.R295T	TCGA-BR-4361	STAD	TCGA	LKTPQVT	DEG_SCF_FBW7_1	302:308	Mutation rewiring degron network	0.1389
p.F192L	TCGA-BS-A0TC	UCEC	TCGA	ALSSS	DEG_SPOP_SBC_1	181:185	Mutation rewiring degron network	0.1389
p.F192L	DO222762	COCA	ICGC	ALSSS	DEG_SPOP_SBC_1	181:185	Mutation rewiring degron network	0.1389
p.F192L	DO42400	UCEC	ICGC	ALSSS	DEG_SPOP_SBC_1	181:185	Mutation rewiring degron network	0.1389
p.E267K	TCGA-CR-7373	HNSC	TCGA	DAARTYSTAP	CBL_PTK	256:265	Mutation rewiring degron network	0.2778
p.E267K	TCGA-EE-A2M6	SKCM	TCGA	DAARTYSTAP	CBL_PTK	256:265	Mutation rewiring degron network	0.2778
p.S262N	TCGA-D1-A16X	UCEC	TCGA	DAARTYSTAP	CBL_PTK	256:265	Mutation altering degron motif	0.7069
p.G311E	TCGA-D3-A2JK	SKCM	TCGA	LKTPQVT	DEG_SCF_FBW7_1	302:308	Mutation rewiring degron network	0.25
p.E310K	TCGA-DK-A1AE	BLCA	TCGA	LKTPQVT	DEG_SCF_FBW7_1	302:308	Mutation rewiring degron network	0.2778
p.S185L	TCGA-DU-7304	LGG	TCGA	ALSSS	DEG_SPOP_SBC_1	181:185	Mutation altering degron motif	0.7667
p.S185L	DO50436	ESAD	ICGC	ALSSS	DEG_SPOP_SBC_1	181:185	Mutation altering degron motif	0.7667
p.S185L	DO22397	LGG	ICGC	ALSSS	DEG_SPOP_SBC_1	181:185	Mutation altering degron motif	0.7667
p.G270E	TCGA-EC-A1QX	UCEC	TCGA	DAARTYSTAP	CBL_PTK	256:265	Mutation rewiring degron network	0.1944
p.G270E	SIDM01159	Other Sarcomas	GDSC	DAARTYSTAP	CBL_PTK	256:265	Mutation rewiring degron network	0.1944
p.G270E	SW872	soft tissue	COSMIC	DAARTYSTAP	CBL_PTK	256:265	Mutation rewiring degron network	0.1944
p.D301N	TCGA-EE-A180	SKCM	TCGA	LKTPQVT	DEG_SCF_FBW7_1	302:308	Mutation rewiring degron network	0.3056
p.G294E	TCGA-EE-A29M	SKCM	TCGA	LKTPQVT	DEG_SCF_FBW7_1	302:308	Mutation rewiring degron network	0.1111
p.V248F	TCGA-EO-A22R	UCEC	TCGA	DAARTYSTAP	CBL_PTK	256:265	Mutation rewiring degron network	0.1111
p.E359D	TCGA-EO-A22R	UCEC	TCGA	LKTPQVT	DEG_SCF_FBW7_1	363:369	Mutation rewiring degron network	0.2222
p.E359D	DO9876	COAD	ICGC	LKTPQVT	DEG_SCF_FBW7_1	363:369	Mutation rewiring degron network	0.2222
p.D174N	TCGA-ER-A19Q	SKCM	TCGA	ALSSS	DEG_SPOP_SBC_1	181:185	Mutation rewiring degron network	0.1389
p.D174N	DO47497	SKCM	ICGC	ALSSS	DEG_SPOP_SBC_1	181:185	Mutation rewiring degron network	0.1389
p.E171K	TCGA-FR-A8YC	SKCM	TCGA	ALSSS	DEG_SPOP_SBC_1	181:185	Mutation rewiring degron network	0.0556
p.E171K	TCGA-FS-A4F0	SKCM	TCGA	ALSSS	DEG_SPOP_SBC_1	181:185	Mutation rewiring degron network	0.0556
p.E171K	DO222363	MELA	ICGC	ALSSS	DEG_SPOP_SBC_1	181:185	Mutation rewiring degron network	0.0556
p.E171K	DO37891	SKCM	ICGC	ALSSS	DEG_SPOP_SBC_1	181:185	Mutation rewiring degron network	0.0556
p.E171K	DO50301	SKCM	ICGC	ALSSS	DEG_SPOP_SBC_1	181:185	Mutation rewiring degron network	0.0556
p.E371K	TCGA-FS-A4F0	SKCM	TCGA	LKTPQVT	DEG_SCF_FBW7_1	363:369	Mutation rewiring degron network	0.2778
p.E271K	TCGA-FW-A3R5	SKCM	TCGA	DAARTYSTAP	CBL_PTK	256:265	Mutation rewiring degron network	0.1667
p.M254I	TCGA-IH-A3EA	SKCM	TCGA	DAARTYSTAP	CBL_PTK	256:265	Mutation rewiring degron network	0.2778
p.M254I	TCGA-W3-AA1V	SKCM	TCGA	DAARTYSTAP	CBL_PTK	256:265	Mutation rewiring degron network	0.2778
p.Y261H	TCGA-KD-A5QS	SARC	TCGA	DAARTYSTAP	CBL_PTK	256:265	Mutation altering degron motif	0.7229
p.E293Q	TCGA-UY-A9PH	BLCA	TCGA	LKTPQVT	DEG_SCF_FBW7_1	302:308	Mutation rewiring degron network	0.0833
p.G253E	TCGA-VT-A80J	SARC	TCGA	DAARTYSTAP	CBL_PTK	256:265	Mutation rewiring degron network	0.25
p.L249P	TCGA-W3-AA1R	SKCM	TCGA	DAARTYSTAP	CBL_PTK	256:265	Mutation rewiring degron network	0.1389
p.E267Q	DO223594	BLCA	ICGC	DAARTYSTAP	CBL_PTK	256:265	Mutation rewiring degron network	0.2778
p.E307G	DO1275	BRCA	ICGC	LKTPQVT	DEG_SCF_FBW7_1	302:308	Mutation altering degron motif	0.7199
p.S369L	DO49946	CESC	ICGC	LKTPQVT	DEG_SCF_FBW7_1	363:369	Mutation altering degron motif	0.7667
p.H361R	DO9698	COAD	ICGC	LKTPQVT	DEG_SCF_FBW7_1	363:369	Mutation rewiring degron network	0.2778
p.H361R	ACH-002095	Lung Cancer	CCLE	LKTPQVT	DEG_SCF_FBW7_1	363:369	Mutation rewiring degron network	0.2778
p.H361R	COR-L303	lung	COSMIC	LKTPQVT	DEG_SCF_FBW7_1	363:369	Mutation rewiring degron network	0.2778
p.H361N	DO222884	COCA	ICGC	LKTPQVT	DEG_SCF_FBW7_1	363:369	Mutation rewiring degron network	0.2778
p.C292S	DO233944	GACA	ICGC	LKTPQVT	DEG_SCF_FBW7_1	302:308	Mutation rewiring degron network	0.0556
p.E299V	DO228609	LICA	ICGC	LKTPQVT	DEG_SCF_FBW7_1	302:308	Mutation rewiring degron network	0.25
p.G301V	DO228971	LICA	ICGC	LKTPQVT	DEG_SCF_FBW7_1	302:308	Mutation rewiring degron network	0.3056
p.E246D	DO23232	LINC	ICGC	DAARTYSTAP	CBL_PTK	256:265	Mutation rewiring degron network	0.0556
p.S318Y	DO45316	LUAD	ICGC	LKTPQVT	DEG_SCF_FBW7_1	302:308	Mutation rewiring degron network	0.0556
p.E297K	DO26250	LUAD	ICGC	LKTPQVT	DEG_SCF_FBW7_1	302:308	Mutation substituting flanking lysine	0.3056
p.P252S	DO45482	LUSC	ICGC	DAARTYSTAP	CBL_PTK	256:265	Mutation rewiring degron network	0.2222
p.G309E	DO45515	LUSC	ICGC	LKTPQVT	DEG_SCF_FBW7_1	302:308	Mutation rewiring degron network	0.3056
p.E301K	DO220877	MELA	ICGC	LKTPQVT	DEG_SCF_FBW7_1	302:308	Mutation rewiring degron network	0.3056
p.KE259KK	DO222702	MELA	ICGC	DAARTYSTAP	CBL_PTK	256:265	Mutation altering degron motif	0.6667
p.P314T	DO46378	OV	ICGC	LKTPQVT	DEG_SCF_FBW7_1	302:308	Mutation rewiring degron network	0.1667
p.E260D	DO219448	PRAD	ICGC	DAARTYSTAP	CBL_PTK	256:265	Mutation altering degron motif	0.6758
p.E299D	DO36556	READ	ICGC	LKTPQVT	DEG_SCF_FBW7_1	302:308	Mutation rewiring degron network	0.25
p.E180K	DO218874	SKCA	ICGC	ALSSS	DEG_SPOP_SBC_1	181:185	Mutation rewiring degron network	0.3056
p.E295K	DO37891	SKCM	ICGC	LKTPQVT	DEG_SCF_FBW7_1	302:308	Mutation rewiring degron network	0.1389
p.R255K	DO37839	SKCM	ICGC	DAARTYSTAP	CBL_PTK	256:265	Mutation rewiring degron network	0.3056
p.G268E	DO37404	SKCM	ICGC	DAARTYSTAP	CBL_PTK	256:265	Mutation substituting flanking lysine	0.3611
p.D275N	DO47537	SKCM	ICGC	DAARTYSTAP	CBL_PTK	256:265	Mutation rewiring degron network	0.0556
p.E365K	DO51277	SKCM	ICGC	LKTPQVT	DEG_SCF_FBW7_1	363:369	Mutation altering degron motif	0.7022
p.R269T	DO38887	STAD	ICGC	DAARTYSTAP	CBL_PTK	256:265	Mutation rewiring degron network	0.2222
p.K259M	DO38205	STAD	ICGC	DAARTYSTAP	CBL_PTK	256:265	Mutation altering degron motif	0.8062
p.D270G	DO42280	UCEC	ICGC	DAARTYSTAP	CBL_PTK	256:265	Mutation rewiring degron network	0.1944
p.P314S	DO41572	UCEC	ICGC	LKTPQVT	DEG_SCF_FBW7_1	302:308	Mutation rewiring degron network	0.1667
p.E316K	DO41379	UCEC	ICGC	LKTPQVT	DEG_SCF_FBW7_1	302:308	Mutation rewiring degron network	0.1111
p.D256N	SIDM00960	Colorectal Carcinoma	GDSC	DAARTYSTAP	CBL_PTK	256:265	Mutation altering degron motif	0.5821
p.D256N	CL-40	large intestine	COSMIC	DAARTYSTAP	CBL_PTK	256:265	Mutation altering degron motif	0.5821
p.P178L	SIDM00112	Kidney Carcinoma	GDSC	ALSSS	DEG_SPOP_SBC_1	181:185	Mutation rewiring degron network	0.25
p.P178L	ACH-000428	Kidney Cancer	CCLE	ALSSS	DEG_SPOP_SBC_1	181:185	Mutation rewiring degron network	0.25
p.P178L	U031	kidney	COSMIC	ALSSS	DEG_SPOP_SBC_1	181:185	Mutation rewiring degron network	0.25
p.C188R	SIDM00228	Thyroid Gland Carcinoma	GDSC	ALSSS	DEG_SPOP_SBC_1	181:185	Mutation rewiring degron network	0.25
p.C188R	ACH-000897	Thyroid Cancer	CCLE	ALSSS	DEG_SPOP_SBC_1	181:185	Mutation rewiring degron network	0.25
p.E366A	ACH-000484	Kidney Cancer	CCLE	LKTPQVT	DEG_SCF_FBW7_1	363:369	Mutation altering degron motif	0.7701
p.E366A	VMRC-RCW	kidney	COSMIC	LKTPQVT	DEG_SCF_FBW7_1	363:369	Mutation altering degron motif	0.7701
p.S356N	ACH-000501	Colon/Colorectal Cancer	CCLE	LKTPQVT	DEG_SCF_FBW7_1	363:369	Mutation rewiring degron network	0.1389
p.P362Q	ACH-000765	Skin Cancer	CCLE	LKTPQVT	DEG_SCF_FBW7_1	363:369	Mutation rewiring degron network	0.3056
p.D270N	ACH-000791	Lung Cancer	CCLE	DAARTYSTAP	CBL_PTK	256:265	Mutation rewiring degron network	0.1944
p.S251N	ACH-000888	Lung Cancer	CCLE	DAARTYSTAP	CBL_PTK	256:265	Mutation rewiring degron network	0.1944
p.S251N	NCI-H1793	lung	COSMIC	DAARTYSTAP	CBL_PTK	256:265	Mutation rewiring degron network	0.1944
p.D258Y	ACH-000996	Endometrial/Uterine Cancer	CCLE	DAARTYSTAP	CBL_PTK	256:265	Mutation altering degron motif	0.7325
p.Q263K	ACH-000997	Colon/Colorectal Cancer	CCLE	DAARTYSTAP	CBL_PTK	256:265	Mutation altering degron motif	0.6944
p.Q263K	ACH-001061	Colon/Colorectal Cancer	CCLE	DAARTYSTAP	CBL_PTK	256:265	Mutation altering degron motif	0.6944
p.Q263K	HCT-15	large intestine	COSMIC	DAARTYSTAP	CBL_PTK	256:265	Mutation altering degron motif	0.6944
p.N256S	ACH-000998	Colon/Colorectal Cancer	CCLE	DAARTYSTAP	CBL_PTK	256:265	Mutation altering degron motif	0.7069
p.N256S	CW-2	large intestine	COSMIC	DAARTYSTAP	CBL_PTK	256:265	Mutation altering degron motif	0.7069
p.Q179R	ACH-001354	Neuroblastoma	CCLE	ALSSS	DEG_SPOP_SBC_1	181:185	Mutation rewiring degron network	0.2778
p.A181T	ACH-002038	Ovarian Cancer	CCLE	ALSSS	DEG_SPOP_SBC_1	181:185	Mutation altering degron motif	0.7139
p.N364S	ACH-002200	Skin Cancer	CCLE	LKTPQVT	DEG_SCF_FBW7_1	363:369	Mutation altering degron motif	0.7069
p.N364S	SW962	vulva	COSMIC	LKTPQVT	DEG_SCF_FBW7_1	363:369	Mutation altering degron motif	0.7069
p.A363V	SNU-407	large intestine	COSMIC	LKTPQVT	DEG_SCF_FBW7_1	363:369	Mutation altering degron motif	0.6936
p.D368Y	NCI-H1876	lung	COSMIC	LKTPQVT	DEG_SCF_FBW7_1	363:369	Mutation altering degron motif	0.7325
p.S275N	L-428	haematopoietic and lymphoid tissue	COSMIC	DAARTYSTAP	CBL_PTK	256:265	Mutation rewiring degron network	0.0556
p.N310S	SW962	vulva	COSMIC	LKTPQVT	DEG_SCF_FBW7_1	302:308	Mutation rewiring degron network	0.2778
p.H307R	COR-L303	lung	COSMIC	LKTPQVT	DEG_SCF_FBW7_1	302:308	Mutation altering degron motif	0.8244
p.E312A	VMRC-RCW	kidney	COSMIC	LKTPQVT	DEG_SCF_FBW7_1	302:308	Mutation rewiring degron network	0.2222
p.S353N	NCI-H1435	lung	COSMIC	LKTPQVT	DEG_SCF_FBW7_1	363:369	Mutation rewiring degron network	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SP140

UniProt ID: Q13342

Entrez ID: 11262

Protein name: Nuclear body protein SP140 (Lymphoid-restricted homolog of Sp100) (LYSp100) (Nuclear autoantigen Sp-140) (Speckled 140 kDa)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SP140 in