DegronMD

Uniprot ID: Q13342

Source protein: Nuclear body protein SP140

Source gene: SP140

Class: DEG_SCF_FBW7_1

Location: 363:369

E3 ligase: FBXW7

DEGRON score: 0.923

ASA_SCORE: 87.9714

COIL: 0.7536

CONS_SCORE: 0.4773

DSS_SCORE: 0.5997

HELIX: 0.0701

FCONS_SCORE: 0.9634

RIG_SCORE: 0.7247

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A358S	TCGA-34-5241	LUSC	TCGA	LKTPQVT	DEG_SCF_FBW7_1	0.1944
p.E359D	TCGA-EO-A22R	UCEC	TCGA	LKTPQVT	DEG_SCF_FBW7_1	0.2222
p.E359D	DO9876	COAD	ICGC	LKTPQVT	DEG_SCF_FBW7_1	0.2222
p.E371K	TCGA-FS-A4F0	SKCM	TCGA	LKTPQVT	DEG_SCF_FBW7_1	0.2778
p.S369L	DO49946	CESC	ICGC	LKTPQVT	DEG_SCF_FBW7_1	0.7667
p.H361R	DO9698	COAD	ICGC	LKTPQVT	DEG_SCF_FBW7_1	0.2778
p.H361R	ACH-002095	Lung Cancer	CCLE	LKTPQVT	DEG_SCF_FBW7_1	0.2778
p.H361R	COR-L303	lung	COSMIC	LKTPQVT	DEG_SCF_FBW7_1	0.2778
p.H361N	DO222884	COCA	ICGC	LKTPQVT	DEG_SCF_FBW7_1	0.2778
p.E365K	DO51277	SKCM	ICGC	LKTPQVT	DEG_SCF_FBW7_1	0.7022
p.E366A	ACH-000484	Kidney Cancer	CCLE	LKTPQVT	DEG_SCF_FBW7_1	0.7701
p.E366A	VMRC-RCW	kidney	COSMIC	LKTPQVT	DEG_SCF_FBW7_1	0.7701
p.S356N	ACH-000501	Colon/Colorectal Cancer	CCLE	LKTPQVT	DEG_SCF_FBW7_1	0.1389
p.P362Q	ACH-000765	Skin Cancer	CCLE	LKTPQVT	DEG_SCF_FBW7_1	0.3056
p.N364S	ACH-002200	Skin Cancer	CCLE	LKTPQVT	DEG_SCF_FBW7_1	0.7069
p.N364S	SW962	vulva	COSMIC	LKTPQVT	DEG_SCF_FBW7_1	0.7069
p.A363V	SNU-407	large_intestine	COSMIC	LKTPQVT	DEG_SCF_FBW7_1	0.6936
p.D368Y	NCI-H1876	lung	COSMIC	LKTPQVT	DEG_SCF_FBW7_1	0.7325
p.S353N	NCI-H1435	lung	COSMIC	LKTPQVT	DEG_SCF_FBW7_1	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons