DegronMD

Uniprot ID: Q13342

Source protein: Nuclear body protein SP140

Source gene: SP140

Class: DEG_SCF_FBW7_1

Location: 302:308

E3 ligase: FBXW7

DEGRON score: 0.9077

ASA_SCORE: 94.5571

COIL: 0.8439

CONS_SCORE: 0.5665

DSS_SCORE: 0.7263

HELIX: 0.0734

FCONS_SCORE: 1.1813

RIG_SCORE: 0.6942

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D296G	TCGA-AX-A1CE	UCEC	TCGA	LKTPQVT	DEG_SCF_FBW7_1	0.1667
p.V307F	TCGA-AX-A2HC	UCEC	TCGA	LKTPQVT	DEG_SCF_FBW7_1	0.5957
p.R295T	TCGA-BR-4361	STAD	TCGA	LKTPQVT	DEG_SCF_FBW7_1	0.1389
p.G311E	TCGA-D3-A2JK	SKCM	TCGA	LKTPQVT	DEG_SCF_FBW7_1	0.25
p.E310K	TCGA-DK-A1AE	BLCA	TCGA	LKTPQVT	DEG_SCF_FBW7_1	0.2778
p.D301N	TCGA-EE-A180	SKCM	TCGA	LKTPQVT	DEG_SCF_FBW7_1	0.3056
p.G294E	TCGA-EE-A29M	SKCM	TCGA	LKTPQVT	DEG_SCF_FBW7_1	0.1111
p.E293Q	TCGA-UY-A9PH	BLCA	TCGA	LKTPQVT	DEG_SCF_FBW7_1	0.0833
p.E307G	DO1275	BRCA	ICGC	LKTPQVT	DEG_SCF_FBW7_1	0.7199
p.C292S	DO233944	GACA	ICGC	LKTPQVT	DEG_SCF_FBW7_1	0.0556
p.E299V	DO228609	LICA	ICGC	LKTPQVT	DEG_SCF_FBW7_1	0.25
p.G301V	DO228971	LICA	ICGC	LKTPQVT	DEG_SCF_FBW7_1	0.3056
p.S318Y	DO45316	LUAD	ICGC	LKTPQVT	DEG_SCF_FBW7_1	0.0556
p.E297K	DO26250	LUAD	ICGC	LKTPQVT	DEG_SCF_FBW7_1	0.3056
p.G309E	DO45515	LUSC	ICGC	LKTPQVT	DEG_SCF_FBW7_1	0.3056
p.E301K	DO220877	MELA	ICGC	LKTPQVT	DEG_SCF_FBW7_1	0.3056
p.P314T	DO46378	OV	ICGC	LKTPQVT	DEG_SCF_FBW7_1	0.1667
p.E299D	DO36556	READ	ICGC	LKTPQVT	DEG_SCF_FBW7_1	0.25
p.E295K	DO37891	SKCM	ICGC	LKTPQVT	DEG_SCF_FBW7_1	0.1389
p.P314S	DO41572	UCEC	ICGC	LKTPQVT	DEG_SCF_FBW7_1	0.1667
p.E316K	DO41379	UCEC	ICGC	LKTPQVT	DEG_SCF_FBW7_1	0.1111
p.N310S	SW962	vulva	COSMIC	LKTPQVT	DEG_SCF_FBW7_1	0.2778
p.H307R	COR-L303	lung	COSMIC	LKTPQVT	DEG_SCF_FBW7_1	0.8244
p.E312A	VMRC-RCW	kidney	COSMIC	LKTPQVT	DEG_SCF_FBW7_1	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons