DegronMD

Uniprot ID: Q13342

Source protein: Nuclear body protein SP140

Source gene: SP140

Class: DEG_SPOP_SBC_1

Location: 181:185

E3 ligase: SPOP

DEGRON score: 0.969

ASA_SCORE: 66.9

COIL: 0.7442

CONS_SCORE: 0.5297

DSS_SCORE: 0.5386

HELIX: 0.2488

FCONS_SCORE: 1.0789

RIG_SCORE: 0.649

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S185L	TCGA-DU-7304	LGG	TCGA	ALSSS	DEG_SPOP_SBC_1	0.7667
p.S185L	DO50436	ESAD	ICGC	ALSSS	DEG_SPOP_SBC_1	0.7667
p.S185L	DO22397	LGG	ICGC	ALSSS	DEG_SPOP_SBC_1	0.7667
p.A181T	ACH-002038	Ovarian Cancer	CCLE	ALSSS	DEG_SPOP_SBC_1	0.7139
p.S183N	TCGA-2W-A8YY	CESC	TCGA	ALSSS	DEG_SPOP_SBC_1	0.7069
p.S183N	DO223732	CESC	ICGC	ALSSS	DEG_SPOP_SBC_1	0.7069
p.L182F	TCGA-5L-AAT1	BRCA	TCGA	ALSSS	DEG_SPOP_SBC_1	0.587
p.L182F	DO219594	BRCA	ICGC	ALSSS	DEG_SPOP_SBC_1	0.587
p.E180K	DO218874	SKCA	ICGC	ALSSS	DEG_SPOP_SBC_1	0.3056
p.Q179R	ACH-001354	Neuroblastoma	CCLE	ALSSS	DEG_SPOP_SBC_1	0.2778
p.P178L	SIDM00112	Kidney Carcinoma	GDSC	ALSSS	DEG_SPOP_SBC_1	0.25
p.P178L	ACH-000428	Kidney Cancer	CCLE	ALSSS	DEG_SPOP_SBC_1	0.25
p.P178L	U031	kidney	COSMIC	ALSSS	DEG_SPOP_SBC_1	0.25
p.C188R	SIDM00228	Thyroid Gland Carcinoma	GDSC	ALSSS	DEG_SPOP_SBC_1	0.25
p.C188R	ACH-000897	Thyroid Cancer	CCLE	ALSSS	DEG_SPOP_SBC_1	0.25
p.F192L	TCGA-BS-A0TC	UCEC	TCGA	ALSSS	DEG_SPOP_SBC_1	0.1389
p.F192L	DO222762	COCA	ICGC	ALSSS	DEG_SPOP_SBC_1	0.1389
p.F192L	DO42400	UCEC	ICGC	ALSSS	DEG_SPOP_SBC_1	0.1389
p.D174N	TCGA-ER-A19Q	SKCM	TCGA	ALSSS	DEG_SPOP_SBC_1	0.1389
p.D174N	DO47497	SKCM	ICGC	ALSSS	DEG_SPOP_SBC_1	0.1389
p.M172I	TCGA-49-AARQ	LUAD	TCGA	ALSSS	DEG_SPOP_SBC_1	0.0833
p.M172I	DO229019	LICA	ICGC	ALSSS	DEG_SPOP_SBC_1	0.0833
p.M172I	DO51189	LUAD	ICGC	ALSSS	DEG_SPOP_SBC_1	0.0833
p.E171K	TCGA-FR-A8YC	SKCM	TCGA	ALSSS	DEG_SPOP_SBC_1	0.0556
p.E171K	TCGA-FS-A4F0	SKCM	TCGA	ALSSS	DEG_SPOP_SBC_1	0.0556

Showing 1 to 25 of 28 entries

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Drug responses associated with SP140 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of ALSSS

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q4KWH8	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1	DEG_SPOP_SBC_1	1260:1264	ALSSS	SPOP	0.7764	More...
P53999	Activated RNA polymerase II transcriptional coactivator p15	DEG_SPOP_SBC_1	48:52	ALSSS	SPOP	0.9949	More...
Q9NQW6	Anillin	DEG_SPOP_SBC_1	272:276	ALSSS	SPOP	0.9996	More...
Q9P2G1	Ankyrin repeat and IBR domain-containing protein 1	DEG_SPOP_SBC_1	909:913	ALSSS	SPOP	0.9517	More...
Q8IZC6	Collagen alpha-1	DEG_SPOP_SBC_1	486:490	ALSSS	SPOP	0.9813	More...
Q6UUV9	CREB-regulated transcription coactivator 1	DEG_SPOP_SBC_1	271:275	ALSSS	SPOP	0.9811	More...
Q53ET0	CREB-regulated transcription coactivator 2	DEG_SPOP_SBC_1	396:400	ALSSS	SPOP	0.9946	More...
Q70SY1	Cyclic AMP-responsive element-binding protein 3-like protein 2	DEG_SPOP_SBC_1	245:249	ALSSS	SPOP	0.9922	More...
Q9BTC0	Death-inducer obliterator 1	DEG_SPOP_SBC_1	2049:2053	ALSSS	SPOP	0.9596	More...
Q16531	DNA damage-binding protein 1	DEG_SPOP_SBC_1	760:764	ALSSS	SPOP	0.9918	More...
Q8IXT1	DNA damage-induced apoptosis suppressor protein	DEG_SPOP_SBC_1	541:545	ALSSS	SPOP	0.9938	More...
Q56P03	E2F-associated phosphoprotein	DEG_SPOP_SBC_1	22:26	ALSSS	SPOP	0.96	More...
Q06587	E3 ubiquitin-protein ligase RING1	DEG_SPOP_SBC_1	136:140	ALSSS	SPOP	0.9879	More...
Q52LR7	Enhancer of polycomb homolog 2	DEG_SPOP_SBC_1	684:688	ALSSS	SPOP	0.9033	More...
O14681	Etoposide-induced protein 2.4 homolog	DEG_SPOP_SBC_1	314:318	ALSSS	SPOP	0.7903	More...
Q86X51	EZH inhibitory protein	DEG_SPOP_SBC_1	59:63	ALSSS	SPOP	0.8892	More...
Q99501	GAS2-like protein 1	DEG_SPOP_SBC_1	597:601	ALSSS	SPOP	0.9987	More...
Q9UFP1	Golgi-associated kinase 1A	DEG_SPOP_SBC_1	63:67	ALSSS	SPOP	0.9976	More...
Q8NEZ4	Histone-lysine N-methyltransferase 2C	DEG_SPOP_SBC_1	803:807	ALSSS	SPOP	0.8649	More...
Q6DN90	IQ motif and SEC7 domain-containing protein 1	DEG_SPOP_SBC_1	921:925	ALSSS	SPOP	0.9622	More...
Q5JU85	IQ motif and SEC7 domain-containing protein 2	DEG_SPOP_SBC_1	1139:1143	ALSSS	SPOP	0.7552	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	1730:1734	ALSSS	SPOP	0.9832	More...
P48681	Nestin	DEG_SPOP_SBC_1	1448:1452	ALSSS	SPOP	0.968	More...
Q9H2A3	Neurogenin-2	DEG_SPOP_SBC_1	200:204	ALSSS	SPOP	0.923	More...
Q8NEJ9	Neuroguidin	DEG_SPOP_SBC_1	200:204	ALSSS	SPOP	0.9753	More...

Showing 1 to 25 of 42 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ALSSS

Degron related mutations and impact score

Drug responses associated with SP140 mutations

All proteins holding degron of ALSSS