DegronMD - Q5JU85(IQSEC2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D1149N	TCGA-98-8021	LUSC	TCGA	ALSSS	DEG_SPOP_SBC_1	1139:1143	Mutation rewiring degron network	0.1667
p.D1146E	TCGA-A1-A0SN	BRCA	TCGA	ALSSS	DEG_SPOP_SBC_1	1139:1143	Mutation rewiring degron network	0.25
p.P1280S	TCGA-AP-A059	UCEC	TCGA	PPPY	ITCH	1279:1282	Mutation altering degron motif	0.6752
p.P1280S	DO41361	UCEC	ICGC	PPPY	ITCH	1279:1282	Mutation altering degron motif	0.6752
p.L516I	TCGA-AX-A2HC	UCEC	TCGA	LPLYLD	LIG_APCC_ABBA_1	516:521	Mutation altering degron motif	0.6063
p.G283A	TCGA-BR-8368	STAD	TCGA	PPSSS	DEG_SPOP_SBC_1	275:279	Mutation rewiring degron network	0.2222
p.G283A	TCGA-D7-A4YV	STAD	TCGA	PPSSS	DEG_SPOP_SBC_1	275:279	Mutation rewiring degron network	0.2222
p.G283A	TCGA-DF-A2KU	UCEC	TCGA	PPSSS	DEG_SPOP_SBC_1	275:279	Mutation rewiring degron network	0.2222
p.G283A	ACH-000941	Endometrial/Uterine Cancer	CCLE	PPSSS	DEG_SPOP_SBC_1	275:279	Mutation rewiring degron network	0.2222
p.G283A	ACH-000954	Endometrial/Uterine Cancer	CCLE	PPSSS	DEG_SPOP_SBC_1	275:279	Mutation rewiring degron network	0.2222
p.G283A	ACH-001517	Endometrial/Uterine Cancer	CCLE	PPSSS	DEG_SPOP_SBC_1	275:279	Mutation rewiring degron network	0.2222
p.K1152R	TCGA-D1-A0ZO	UCEC	TCGA	ALSSS	DEG_SPOP_SBC_1	1139:1143	Mutation substituting flanking lysine	0.1944
p.K1152R	DO41927	UCEC	ICGC	ALSSS	DEG_SPOP_SBC_1	1139:1143	Mutation substituting flanking lysine	0.1944
p.A137T	TCGA-D1-A17M	UCEC	TCGA	REAVYRD	LIG_APCC_ABBAyCdc20_2	126:132	Mutation rewiring degron network	0.1944
p.A137T	DO43779	UCEC	ICGC	REAVYRD	LIG_APCC_ABBAyCdc20_2	126:132	Mutation rewiring degron network	0.1944
p.K1136T	TCGA-D7-6528	STAD	TCGA	ALSSS	DEG_SPOP_SBC_1	1139:1143	Mutation substituting flanking lysine	0.3611
p.D1133N	TCGA-DF-A2KU	UCEC	TCGA	ALSSS	DEG_SPOP_SBC_1	1139:1143	Mutation blocking phosphorylation signal	0.6111
p.S272R	TCGA-EO-A3B0	UCEC	TCGA	PPSSS	DEG_SPOP_SBC_1	275:279	Mutation rewiring degron network	0.25
p.A1139T	TCGA-OL-A5RU	BRCA	TCGA	ALSSS	DEG_SPOP_SBC_1	1139:1143	Mutation altering degron motif	0.7139
p.V129E	DO5724	BRCA	ICGC	REAVYRD	LIG_APCC_ABBAyCdc20_2	126:132	Mutation altering degron motif	0.7693
p.S508F	DO51631	CESC	ICGC	LPLYLD	LIG_APCC_ABBA_1	516:521	Mutation rewiring degron network	0.1111
p.E284K	DO48986	CESC	ICGC	PPSSS	DEG_SPOP_SBC_1	275:279	Mutation rewiring degron network	0.1944
p.E272K	DO233767	GACA	ICGC	PPSSS	DEG_SPOP_SBC_1	275:279	Mutation rewiring degron network	0.25
p.P281H	DO229006	LICA	ICGC	PPSSS	DEG_SPOP_SBC_1	275:279	Mutation rewiring degron network	0.2778
p.L141Q	DO50859	LIRI	ICGC	REAVYRD	LIG_APCC_ABBAyCdc20_2	126:132	Mutation rewiring degron network	0.0833
p.C525S	DO218922	LUAD	ICGC	LPLYLD	LIG_APCC_ABBA_1	516:521	Mutation rewiring degron network	0.2222
p.R531L	DO24702	LUAD	ICGC	LPLYLD	LIG_APCC_ABBA_1	516:521	Mutation rewiring degron network	0.0556
p.D126Y	DO231049	LUSC	ICGC	REAVYRD	LIG_APCC_ABBAyCdc20_2	126:132	Mutation altering degron motif	0.7325
p.P520S	DO37507	SKCM	ICGC	LPLYLD	LIG_APCC_ABBA_1	516:521	Mutation altering degron motif	0.6752
p.S139F	DO37881	SKCM	ICGC	REAVYRD	LIG_APCC_ABBAyCdc20_2	126:132	Mutation blocking phosphorylation signal	0.5833
p.P278Q	DO37438	SKCM	ICGC	PPSSS	DEG_SPOP_SBC_1	275:279	Mutation altering degron motif	0.7035
p.Y1282H	DO229264	THCA	ICGC	PPPY	ITCH	1279:1282	Mutation altering degron motif	0.7229
p.Y1282H	DO229272	THCA	ICGC	PPPY	ITCH	1279:1282	Mutation altering degron motif	0.7229
p.L1283P	DO229275	THCA	ICGC	PPPY	ITCH	1279:1282	Mutation rewiring degron network	0.3056
p.L124M	DO223286	UCEC	ICGC	REAVYRD	LIG_APCC_ABBAyCdc20_2	126:132	Mutation rewiring degron network	0.2778
p.R513W	DO43154	UCEC	ICGC	LPLYLD	LIG_APCC_ABBA_1	516:521	Mutation rewiring degron network	0.25
p.P278L	DO41871	UCEC	ICGC	PPSSS	DEG_SPOP_SBC_1	275:279	Mutation altering degron motif	0.7582
p.D271N	DO52426	UCEC	ICGC	PPSSS	DEG_SPOP_SBC_1	275:279	Mutation rewiring degron network	0.2222
p.G287W	DO41199	UCEC	ICGC	PPSSS	DEG_SPOP_SBC_1	275:279	Mutation rewiring degron network	0.1111
p.E119G	DO42713	UCEC	ICGC	REAVYRD	LIG_APCC_ABBAyCdc20_2	126:132	Mutation rewiring degron network	0.1389
p.T1238M	SIDM01943	Colorectal Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	1230:1234	Mutation rewiring degron network	0.2222
p.P284S	SIDM00428	Acute Myeloid Leukemia	GDSC	PPSSS	DEG_SPOP_SBC_1	275:279	Mutation rewiring degron network	0.1944
p.P284S	ACH-000294	Leukemia	CCLE	PPSSS	DEG_SPOP_SBC_1	275:279	Mutation rewiring degron network	0.1944
p.S277T	SIDM00845	Burkitt's Lymphoma	GDSC	PPSSS	DEG_SPOP_SBC_1	275:279	Mutation altering degron motif	0.6005
p.E120D	SIDM00845	Burkitt's Lymphoma	GDSC	REAVYRD	LIG_APCC_ABBAyCdc20_2	126:132	Mutation rewiring degron network	0.1667
p.R531Q	SIDM01483	Melanoma	GDSC	LPLYLD	LIG_APCC_ABBA_1	516:521	Mutation rewiring degron network	0.0556
p.R531Q	ACH-000582	Skin Cancer	CCLE	LPLYLD	LIG_APCC_ABBA_1	516:521	Mutation rewiring degron network	0.0556
p.R531Q	COLO-741	large intestine	COSMIC	LPLYLD	LIG_APCC_ABBA_1	516:521	Mutation rewiring degron network	0.0556
p.S1141R	SIDM00577	Neuroblastoma	GDSC	ALSSS	DEG_SPOP_SBC_1	1139:1143	Mutation altering degron motif	0.7427
p.S1141R	ACH-001603	Neuroblastoma	CCLE	ALSSS	DEG_SPOP_SBC_1	1139:1143	Mutation altering degron motif	0.7427
p.S1141R	NH-12	autonomic ganglia	COSMIC	ALSSS	DEG_SPOP_SBC_1	1139:1143	Mutation altering degron motif	0.7427
p.S272N	SIDM00220	Ovarian Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	275:279	Mutation rewiring degron network	0.25
p.S272N	ACH-000962	Ovarian Cancer	CCLE	PPSSS	DEG_SPOP_SBC_1	275:279	Mutation rewiring degron network	0.25
p.S272N	ACH-001145	Ovarian Cancer	CCLE	PPSSS	DEG_SPOP_SBC_1	275:279	Mutation rewiring degron network	0.25
p.S509A	ACH-000937	Leukemia	CCLE	LPLYLD	LIG_APCC_ABBA_1	516:521	Mutation rewiring degron network	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

IQSEC2

UniProt ID: Q5JU85

Entrez ID: 23096

Protein name: IQ motif and SEC7 domain-containing protein 2

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for IQSEC2 in