DegronMD

Uniprot ID: Q5JU85

Source protein: IQ motif and SEC7 domain-containing protein 2

Source gene: IQSEC2

Class: LIG_APCC_ABBAyCdc20_2

Location: 126:132

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9453

ASA_SCORE: 106.6143

COIL: 0.5941

CONS_SCORE: 0.2609

DSS_SCORE: 0.5634

HELIX: 0.3589

FCONS_SCORE: 0.9919

RIG_SCORE: 0.7793

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V129E	DO5724	BRCA	ICGC	REAVYRD	LIG_APCC_ABBAyCdc20_2	0.7693
p.D126Y	DO231049	LUSC	ICGC	REAVYRD	LIG_APCC_ABBAyCdc20_2	0.7325
p.S139F	DO37881	SKCM	ICGC	REAVYRD	LIG_APCC_ABBAyCdc20_2	0.5833
p.L124M	DO223286	UCEC	ICGC	REAVYRD	LIG_APCC_ABBAyCdc20_2	0.2778
p.A137T	TCGA-D1-A17M	UCEC	TCGA	REAVYRD	LIG_APCC_ABBAyCdc20_2	0.1944
p.A137T	DO43779	UCEC	ICGC	REAVYRD	LIG_APCC_ABBAyCdc20_2	0.1944
p.E120D	SIDM00845	Burkitt's Lymphoma	GDSC	REAVYRD	LIG_APCC_ABBAyCdc20_2	0.1667
p.E119G	DO42713	UCEC	ICGC	REAVYRD	LIG_APCC_ABBAyCdc20_2	0.1389
p.L141Q	DO50859	LIRI	ICGC	REAVYRD	LIG_APCC_ABBAyCdc20_2	0.0833

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5JU85	IQ motif and SEC7 domain-containing protein 2	LIG_APCC_ABBAyCdc20_2	126:132	REAVYRD	APC,CDC20,FZR1	0.9453	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons