DegronMD

Uniprot ID: Q5JU85

Source protein: IQ motif and SEC7 domain-containing protein 2

Source gene: IQSEC2

Class: LIG_APCC_ABBA_1

Location: 516:521

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8674

ASA_SCORE: 65.75

COIL: 0.7027

CONS_SCORE: 0.3228

DSS_SCORE: 0.7336

HELIX: 0.0963

FCONS_SCORE: 0.9248

RIG_SCORE: 0.7078

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L516I	TCGA-AX-A2HC	UCEC	TCGA	LPLYLD	LIG_APCC_ABBA_1	0.6063
p.S508F	DO51631	CESC	ICGC	LPLYLD	LIG_APCC_ABBA_1	0.1111
p.C525S	DO218922	LUAD	ICGC	LPLYLD	LIG_APCC_ABBA_1	0.2222
p.R531L	DO24702	LUAD	ICGC	LPLYLD	LIG_APCC_ABBA_1	0.0556
p.P520S	DO37507	SKCM	ICGC	LPLYLD	LIG_APCC_ABBA_1	0.6752
p.R513W	DO43154	UCEC	ICGC	LPLYLD	LIG_APCC_ABBA_1	0.25
p.R531Q	SIDM01483	Melanoma	GDSC	LPLYLD	LIG_APCC_ABBA_1	0.0556
p.R531Q	ACH-000582	Skin Cancer	CCLE	LPLYLD	LIG_APCC_ABBA_1	0.0556
p.R531Q	COLO-741	large_intestine	COSMIC	LPLYLD	LIG_APCC_ABBA_1	0.0556
p.S509A	ACH-000937	Leukemia	CCLE	LPLYLD	LIG_APCC_ABBA_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5JU85	IQ motif and SEC7 domain-containing protein 2	LIG_APCC_ABBA_1	516:521	LPLYLD	APC,CDC20,FZR1	0.8674	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons