DegronMD - P22736(NR4A1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G123S	TCGA-23-1121	OV	TCGA	ALSSS	DEG_SPOP_SBC_1	123:127	Mutation altering degron motif	0.6993
p.D260N	TCGA-KL-8326	KICH	TCGA	ILDTPVTS	DEG_SCF_FBW7_1	245:252	Mutation rewiring degron network	0.1111
p.D260N	TCGA-KL-8326	KICH	TCGA	PVTST	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.1389
p.D260N	DO220334	KICH	ICGC	ILDTPVTS	DEG_SCF_FBW7_1	245:252	Mutation rewiring degron network	0.1111
p.D260N	DO220334	KICH	ICGC	PVTST	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.1389
p.A247P	TCGA-L5-A4OX	ESCA	TCGA	ILDTPVTS	DEG_SCF_FBW7_1	245:252	Mutation altering degron motif	0.7503
p.A247E	TCGA-L5-A4OX	ESCA	TCGA	ILDTPVTS	DEG_SCF_FBW7_1	245:252	Mutation altering degron motif	0.7701
p.G131S	TCGA-UD-AAC1	MESO	TCGA	ALSSS	DEG_SPOP_SBC_1	123:127	Mutation rewiring degron network	0.2222
p.V121G	TCGA-V1-A9OL	PRAD	TCGA	ALSSS	DEG_SPOP_SBC_1	123:127	Mutation rewiring degron network	0.2778
p.V121G	DO219381	PRAD	ICGC	ALSSS	DEG_SPOP_SBC_1	123:127	Mutation rewiring degron network	0.2778
p.S137W	DO50028	BRCA	ICGC	ALSSS	DEG_SPOP_SBC_1	123:127	Mutation rewiring degron network	0.0556
p.P240S	DO50454	ESAD	ICGC	ILDTPVTS	DEG_SCF_FBW7_1	245:252	Mutation rewiring degron network	0.1944
p.P240S	DO50454	ESAD	ICGC	PVTST	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.0833
p.P240S	SIDM00032	Bladder Carcinoma	GDSC	ILDTPVTS	DEG_SCF_FBW7_1	245:252	Mutation rewiring degron network	0.1944
p.P240S	SIDM00032	Bladder Carcinoma	GDSC	PVTST	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.0833
p.G261C	DO228986	LICA	ICGC	ILDTPVTS	DEG_SCF_FBW7_1	245:252	Mutation rewiring degron network	0.0833
p.G261C	DO228986	LICA	ICGC	PVTST	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.1111
p.S89F	DO222363	MELA	ICGC	ASSTS	DEG_SPOP_SBC_1	85:89	Mutation altering degron motif	0.7982
p.Q89L	DO222749	MELA	ICGC	ASSTS	DEG_SPOP_SBC_1	85:89	Mutation altering degron motif	0.7765
p.A98V	DO229446	SKCA	ICGC	ASSTS	DEG_SPOP_SBC_1	85:89	Mutation rewiring degron network	0.0833
p.P251L	DO229465	SKCA	ICGC	ILDTPVTS	DEG_SCF_FBW7_1	245:252	Mutation altering degron motif	0.7582
p.P251L	DO229465	SKCA	ICGC	PVTST	DEG_SPOP_SBC_1	249:253	Mutation altering degron motif	0.7582
p.D78E	SIDM00646	Small Cell Lung Carcinoma	GDSC	ASSTS	DEG_SPOP_SBC_1	85:89	Mutation rewiring degron network	0.1389
p.D78E	NCI-H1341	lung	COSMIC	ASSTS	DEG_SPOP_SBC_1	85:89	Mutation rewiring degron network	0.1389
p.C132F	SIDM00965	Small Cell Lung Carcinoma	GDSC	ALSSS	DEG_SPOP_SBC_1	123:127	Mutation rewiring degron network	0.1944
p.C132F	NCI-H446	lung	COSMIC	ALSSS	DEG_SPOP_SBC_1	123:127	Mutation rewiring degron network	0.1944
p.S255T	SIDM00345	Non-Small Cell Lung Carcinoma	GDSC	ILDTPVTS	DEG_SCF_FBW7_1	245:252	Mutation rewiring degron network	0.25
p.S255T	SIDM00345	Non-Small Cell Lung Carcinoma	GDSC	PVTST	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.2778
p.S255T	LCLC-103H	lung	COSMIC	ILDTPVTS	DEG_SCF_FBW7_1	245:252	Mutation rewiring degron network	0.25
p.S255T	LCLC-103H	lung	COSMIC	PVTST	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.2778
p.P252R	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	ILDTPVTS	DEG_SCF_FBW7_1	245:252	Mutation altering degron motif	0.7512
p.P252R	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	PVTST	DEG_SPOP_SBC_1	249:253	Mutation altering degron motif	0.7512
p.P252R	NCI-H2342	lung	COSMIC	ILDTPVTS	DEG_SCF_FBW7_1	245:252	Mutation altering degron motif	0.7512
p.P252R	NCI-H2342	lung	COSMIC	PVTST	DEG_SPOP_SBC_1	249:253	Mutation altering degron motif	0.7512
p.T81I	SIDM01025	Esophageal Squamous Cell Carcinoma	GDSC	ASSTS	DEG_SPOP_SBC_1	85:89	Mutation rewiring degron network	0.2222
p.T81I	KYSE-520	oesophagus	COSMIC	ASSTS	DEG_SPOP_SBC_1	85:89	Mutation rewiring degron network	0.2222
p.P96R	ACH-000348	Skin Cancer	CCLE	ASSTS	DEG_SPOP_SBC_1	85:89	Mutation rewiring degron network	0.1389
p.P96R	RPMI-7951	skin	COSMIC	ASSTS	DEG_SPOP_SBC_1	85:89	Mutation rewiring degron network	0.1389
p.T253S	ACH-000733	Lung Cancer	CCLE	PVTST	DEG_SPOP_SBC_1	249:253	Mutation altering degron motif	0.6005
p.T253S	NCI-H1838	lung	COSMIC	PVTST	DEG_SPOP_SBC_1	249:253	Mutation altering degron motif	0.6005
p.C78F	ACH-000800	Lung Cancer	CCLE	ASSTS	DEG_SPOP_SBC_1	85:89	Mutation rewiring degron network	0.1389
p.C78F	NCI-H446	lung	COSMIC	ASSTS	DEG_SPOP_SBC_1	85:89	Mutation rewiring degron network	0.1389
p.R256Q	ACH-000939	Sarcoma	CCLE	ILDTPVTS	DEG_SCF_FBW7_1	245:252	Mutation rewiring degron network	0.2222
p.R256Q	ACH-000939	Sarcoma	CCLE	PVTST	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.25
p.R256Q	ACH-000997	Colon/Colorectal Cancer	CCLE	ILDTPVTS	DEG_SCF_FBW7_1	245:252	Mutation rewiring degron network	0.2222
p.R256Q	ACH-000997	Colon/Colorectal Cancer	CCLE	PVTST	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.25
p.R256Q	ACH-001061	Colon/Colorectal Cancer	CCLE	ILDTPVTS	DEG_SCF_FBW7_1	245:252	Mutation rewiring degron network	0.2222
p.R256Q	ACH-001061	Colon/Colorectal Cancer	CCLE	PVTST	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.25
p.R256Q	SK-UT-1	soft tissue	COSMIC	ILDTPVTS	DEG_SCF_FBW7_1	245:252	Mutation rewiring degron network	0.2222
p.R256Q	SK-UT-1	soft tissue	COSMIC	PVTST	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.25
p.R256Q	HCT-15	large intestine	COSMIC	ILDTPVTS	DEG_SCF_FBW7_1	245:252	Mutation rewiring degron network	0.2222
p.R256Q	HCT-15	large intestine	COSMIC	PVTST	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.25
p.S129F	ACH-000965	Endometrial/Uterine Cancer	CCLE	ALSSS	DEG_SPOP_SBC_1	123:127	Mutation rewiring degron network	0.2778
p.S129F	RL95-2	endometrium	COSMIC	ALSSS	DEG_SPOP_SBC_1	123:127	Mutation rewiring degron network	0.2778
p.Y132C	ACH-000982	Colon/Colorectal Cancer	CCLE	ALSSS	DEG_SPOP_SBC_1	123:127	Mutation rewiring degron network	0.1944
p.Y132C	ACH-001345	Colon/Colorectal Cancer	CCLE	ALSSS	DEG_SPOP_SBC_1	123:127	Mutation rewiring degron network	0.1944
p.Y132C	GP5d	large intestine	COSMIC	ALSSS	DEG_SPOP_SBC_1	123:127	Mutation rewiring degron network	0.1944
p.H239Y	ACH-001378	Pancreatic Cancer	CCLE	ILDTPVTS	DEG_SCF_FBW7_1	245:252	Mutation rewiring degron network	0.1667
p.H239Y	ACH-001378	Pancreatic Cancer	CCLE	PVTST	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.0556
p.S98F	ACH-001550	Skin Cancer	CCLE	ASSTS	DEG_SPOP_SBC_1	85:89	Mutation rewiring degron network	0.0833
p.S98F	MCC13	skin	COSMIC	ASSTS	DEG_SPOP_SBC_1	85:89	Mutation rewiring degron network	0.0833
p.I245V	ACH-001707	Leukemia	CCLE	ILDTPVTS	DEG_SCF_FBW7_1	245:252	Mutation altering degron motif	0.5965
p.S238Y	SNU-1040	large intestine	COSMIC	ILDTPVTS	DEG_SCF_FBW7_1	245:252	Mutation rewiring degron network	0.1389
p.C91F	NCI-H446	lung	COSMIC	ASSTS	DEG_SPOP_SBC_1	85:89	Mutation rewiring degron network	0.2778

Kaplan plot for NR4A1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NR4A1

UniProt ID: P22736

Entrez ID: 3164

Protein name: Nuclear receptor subfamily 4 group A member 1 (Early response protein NAK1) (Nuclear hormone receptor NUR/77) (Nur77) (Orphan nuclear receptor HMR) (Orphan nuclear receptor TR3) (ST-59) (Testicular receptor 3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NR4A1 in