DegronMD

Uniprot ID: P22736

Source protein: Nuclear receptor subfamily 4 group A member 1

Source gene: NR4A1

Class: DEG_SPOP_SBC_1

Location: 249:253

E3 ligase: SPOP

DEGRON score: 0.9805

ASA_SCORE: 90.56

COIL: 0.947

CONS_SCORE: 0.4232

DSS_SCORE: 0.5895

HELIX: 0.0268

FCONS_SCORE: 1.0389

RIG_SCORE: 0.7368

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P251L	DO229465	SKCA	ICGC	PVTST	DEG_SPOP_SBC_1	0.7582
p.P252R	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	PVTST	DEG_SPOP_SBC_1	0.7512
p.P252R	NCI-H2342	lung	COSMIC	PVTST	DEG_SPOP_SBC_1	0.7512
p.T253S	ACH-000733	Lung Cancer	CCLE	PVTST	DEG_SPOP_SBC_1	0.6005
p.T253S	NCI-H1838	lung	COSMIC	PVTST	DEG_SPOP_SBC_1	0.6005
p.S255T	SIDM00345	Non-Small Cell Lung Carcinoma	GDSC	PVTST	DEG_SPOP_SBC_1	0.2778
p.S255T	LCLC-103H	lung	COSMIC	PVTST	DEG_SPOP_SBC_1	0.2778
p.R256Q	ACH-000939	Sarcoma	CCLE	PVTST	DEG_SPOP_SBC_1	0.25
p.R256Q	ACH-000997	Colon/Colorectal Cancer	CCLE	PVTST	DEG_SPOP_SBC_1	0.25
p.R256Q	ACH-001061	Colon/Colorectal Cancer	CCLE	PVTST	DEG_SPOP_SBC_1	0.25
p.R256Q	SK-UT-1	soft_tissue	COSMIC	PVTST	DEG_SPOP_SBC_1	0.25
p.R256Q	HCT-15	large_intestine	COSMIC	PVTST	DEG_SPOP_SBC_1	0.25
p.D260N	TCGA-KL-8326	KICH	TCGA	PVTST	DEG_SPOP_SBC_1	0.1389
p.D260N	DO220334	KICH	ICGC	PVTST	DEG_SPOP_SBC_1	0.1389
p.G261C	DO228986	LICA	ICGC	PVTST	DEG_SPOP_SBC_1	0.1111
p.P240S	DO50454	ESAD	ICGC	PVTST	DEG_SPOP_SBC_1	0.0833
p.P240S	SIDM00032	Bladder Carcinoma	GDSC	PVTST	DEG_SPOP_SBC_1	0.0833
p.H239Y	ACH-001378	Pancreatic Cancer	CCLE	PVTST	DEG_SPOP_SBC_1	0.0556

Showing 1 to 18 of 18 entries

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Drug responses associated with NR4A1 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of PVTST

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13131	5'-AMP-activated protein kinase catalytic subunit alpha-1	DEG_SPOP_SBC_1	450:454	PVTST	SPOP	0.9471	More...
Q5TID7	Coiled-coil domain-containing protein 181	DEG_SPOP_SBC_1	328:332	PVTST	SPOP	0.9574	More...
O75553	Disabled homolog 1	DEG_SPOP_SBC_1	504:508	PVTST	SPOP	0.9801	More...
Q7Z7B0	Filamin-A-interacting protein 1	DEG_SPOP_SBC_1	799:803	PVTST	SPOP	0.9685	More...
Q8TAU0	Homeobox protein Nkx-2.3	DEG_SPOP_SBC_1	6:10	PVTST	SPOP	0.9861	More...
A6NCS4	Homeobox protein Nkx-2.6	DEG_SPOP_SBC_1	5:9	PVTST	SPOP	0.9836	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	12048:12052	PVTST	SPOP	0.6132	More...
Q99102	Mucin-4	DEG_SPOP_SBC_1	43:47	PVTST	SPOP	0.5365	More...
Q99102	Mucin-4	DEG_SPOP_SBC_1	1490:1494	PVTST	SPOP	0.9531	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2221:2225	PVTST	SPOP	0.7357	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3327:3331	PVTST	SPOP	0.6584	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3625:3629	PVTST	SPOP	0.944	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	4058:4062	PVTST	SPOP	0.975	More...
P49790	Nuclear pore complex protein Nup153	DEG_SPOP_SBC_1	1110:1114	PVTST	SPOP	0.9978	More...
P22736	Nuclear receptor subfamily 4 group A member 1	DEG_SPOP_SBC_1	249:253	PVTST	SPOP	0.9805	More...
Q9UHY1	Nuclear receptor-binding protein	DEG_SPOP_SBC_1	33:37	PVTST	SPOP	0.6542	More...
Q8IXQ8	PDZ domain-containing protein 9	DEG_SPOP_SBC_1	131:135	PVTST	SPOP	0.8501	More...
Q6UN15	Pre-mRNA 3'-end-processing factor FIP1	DEG_SPOP_SBC_1	203:207	PVTST	SPOP	0.9115	More...
P55197	Protein AF-10	DEG_SPOP_SBC_1	884:888	PVTST	SPOP	0.8239	More...
Q9Y520	Protein PRRC2C	DEG_SPOP_SBC_1	2269:2273	PVTST	SPOP	0.9984	More...
Q6PL24	Protein TMED8	DEG_SPOP_SBC_1	225:229	PVTST	SPOP	0.9343	More...
Q9P2P6	StAR-related lipid transfer protein 9	DEG_SPOP_SBC_1	4244:4248	PVTST	SPOP	0.8399	More...
O75554	WW domain-binding protein 4	DEG_SPOP_SBC_1	96:100	PVTST	SPOP	0.9878	More...
Q6NXT4	Zinc transporter 6	DEG_SPOP_SBC_1	372:376	PVTST	SPOP	0.9593	More...

Showing 1 to 24 of 24 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PVTST

Degron related mutations and impact score

Drug responses associated with NR4A1 mutations

All proteins holding degron of PVTST