DegronMD - Q6PL24(TMED8)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V226A	TCGA-AA-A00N	COAD	TCGA	PVTST	DEG_SPOP_SBC_1	225:229	Mutation altering degron motif	0.5825
p.V226A	DO9876	COAD	ICGC	PVTST	DEG_SPOP_SBC_1	225:229	Mutation altering degron motif	0.5825
p.D230Y	TCGA-D3-A3CE	SKCM	TCGA	PVTST	DEG_SPOP_SBC_1	225:229	Mutation rewiring degron network	0.3056
p.D230Y	DO37405	SKCM	ICGC	PVTST	DEG_SPOP_SBC_1	225:229	Mutation rewiring degron network	0.3056
p.P225T	TCGA-EE-A20F	SKCM	TCGA	PVTST	DEG_SPOP_SBC_1	225:229	Mutation altering degron motif	0.7031
p.P225T	DO37961	SKCM	ICGC	PVTST	DEG_SPOP_SBC_1	225:229	Mutation altering degron motif	0.7031
p.P225T	SIDM00769	Non-Small Cell Lung Carcinoma	GDSC	PVTST	DEG_SPOP_SBC_1	225:229	Mutation altering degron motif	0.7031
p.P225T	ACH-000733	Lung Cancer	CCLE	PVTST	DEG_SPOP_SBC_1	225:229	Mutation altering degron motif	0.7031
p.P225T	NCI-H1838	lung	COSMIC	PVTST	DEG_SPOP_SBC_1	225:229	Mutation altering degron motif	0.7031
p.G218A	DO228207	LICA	ICGC	PVTST	DEG_SPOP_SBC_1	225:229	Mutation rewiring degron network	0.1389
p.S238Y	DO228974	LICA	ICGC	PVTST	DEG_SPOP_SBC_1	225:229	Mutation rewiring degron network	0.0833
p.D230E	DO229038	LICA	ICGC	PVTST	DEG_SPOP_SBC_1	225:229	Mutation rewiring degron network	0.3056
p.I231T	ACH-000961	Endometrial/Uterine Cancer	CCLE	PVTST	DEG_SPOP_SBC_1	225:229	Mutation rewiring degron network	0.2778

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons