DegronMD

Uniprot ID: Q6PL24

Source protein: Protein TMED8

Source gene: TMED8

Class: DEG_SPOP_SBC_1

Location: 225:229

E3 ligase: SPOP

DEGRON score: 0.9343

ASA_SCORE: 86.08

COIL: 0.8904

CONS_SCORE: 0.5926

DSS_SCORE: 0.3326

HELIX: 0.0304

FCONS_SCORE: 0.818

RIG_SCORE: 0.8182

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V226A	TCGA-AA-A00N	COAD	TCGA	PVTST	DEG_SPOP_SBC_1	0.5825
p.V226A	DO9876	COAD	ICGC	PVTST	DEG_SPOP_SBC_1	0.5825
p.D230Y	TCGA-D3-A3CE	SKCM	TCGA	PVTST	DEG_SPOP_SBC_1	0.3056
p.D230Y	DO37405	SKCM	ICGC	PVTST	DEG_SPOP_SBC_1	0.3056
p.P225T	TCGA-EE-A20F	SKCM	TCGA	PVTST	DEG_SPOP_SBC_1	0.7031
p.P225T	DO37961	SKCM	ICGC	PVTST	DEG_SPOP_SBC_1	0.7031
p.P225T	SIDM00769	Non-Small Cell Lung Carcinoma	GDSC	PVTST	DEG_SPOP_SBC_1	0.7031
p.P225T	ACH-000733	Lung Cancer	CCLE	PVTST	DEG_SPOP_SBC_1	0.7031
p.P225T	NCI-H1838	lung	COSMIC	PVTST	DEG_SPOP_SBC_1	0.7031
p.G218A	DO228207	LICA	ICGC	PVTST	DEG_SPOP_SBC_1	0.1389
p.S238Y	DO228974	LICA	ICGC	PVTST	DEG_SPOP_SBC_1	0.0833
p.D230E	DO229038	LICA	ICGC	PVTST	DEG_SPOP_SBC_1	0.3056
p.I231T	ACH-000961	Endometrial/Uterine Cancer	CCLE	PVTST	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NCS4	Homeobox protein Nkx-2.6	DEG_SPOP_SBC_1	5:9	PVTST	SPOP	0.9836	More...
O75553	Disabled homolog 1	DEG_SPOP_SBC_1	504:508	PVTST	SPOP	0.9801	More...
O75554	WW domain-binding protein 4	DEG_SPOP_SBC_1	96:100	PVTST	SPOP	0.9878	More...
P22736	Nuclear receptor subfamily 4 group A member 1	DEG_SPOP_SBC_1	249:253	PVTST	SPOP	0.9805	More...
P49790	Nuclear pore complex protein Nup153	DEG_SPOP_SBC_1	1110:1114	PVTST	SPOP	0.9978	More...
P55197	Protein AF-10	DEG_SPOP_SBC_1	884:888	PVTST	SPOP	0.8239	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2221:2225	PVTST	SPOP	0.7357	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3327:3331	PVTST	SPOP	0.6584	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3625:3629	PVTST	SPOP	0.944	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	4058:4062	PVTST	SPOP	0.975	More...
Q13131	5'-AMP-activated protein kinase catalytic subunit alpha-1	DEG_SPOP_SBC_1	450:454	PVTST	SPOP	0.9471	More...
Q6NXT4	Zinc transporter 6	DEG_SPOP_SBC_1	372:376	PVTST	SPOP	0.9593	More...
Q6PL24	Protein TMED8	DEG_SPOP_SBC_1	225:229	PVTST	SPOP	0.9343	More...
Q6UN15	Pre-mRNA 3'-end-processing factor FIP1	DEG_SPOP_SBC_1	203:207	PVTST	SPOP	0.9115	More...
Q7Z7B0	Filamin-A-interacting protein 1	DEG_SPOP_SBC_1	799:803	PVTST	SPOP	0.9685	More...
Q8TAU0	Homeobox protein Nkx-2.3	DEG_SPOP_SBC_1	6:10	PVTST	SPOP	0.9861	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	12048:12052	PVTST	SPOP	0.6132	More...
Q99102	Mucin-4	DEG_SPOP_SBC_1	43:47	PVTST	SPOP	0.5365	More...
Q99102	Mucin-4	DEG_SPOP_SBC_1	1490:1494	PVTST	SPOP	0.9531	More...
Q9P2P6	StAR-related lipid transfer protein 9	DEG_SPOP_SBC_1	4244:4248	PVTST	SPOP	0.8399	More...
Q9UHY1	Nuclear receptor-binding protein	DEG_SPOP_SBC_1	33:37	PVTST	SPOP	0.6542	More...
Q9Y520	Protein PRRC2C	DEG_SPOP_SBC_1	2269:2273	PVTST	SPOP	0.9984	More...
Q5TID7	Coiled-coil domain-containing protein 181	DEG_SPOP_SBC_1	328:332	PVTST	SPOP	0.9574	More...
Q8IXQ8	PDZ domain-containing protein 9	DEG_SPOP_SBC_1	131:135	PVTST	SPOP	0.8501	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PVTST

Degron related mutations and impact score

Drug responses associated with TMED8 mutations

All proteins holding degron of PVTST