DegronMD

Uniprot ID: Q8TAU0

Source protein: Homeobox protein Nkx-2.3

Source gene: NKX2-3

Class: DEG_SPOP_SBC_1

Location: 6:10

E3 ligase: SPOP

DEGRON score: 0.9861

ASA_SCORE: 78.74

COIL: 0.909

CONS_SCORE: 0.5852

DSS_SCORE: 0.5136

HELIX: 0.0144

FCONS_SCORE: 0.9748

RIG_SCORE: 0.6967

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T10I	TCGA-24-1471	OV	TCGA	PVTST	DEG_SPOP_SBC_1	0.7078
p.T10I	TCGA-F5-6814	READ	TCGA	PVTST	DEG_SPOP_SBC_1	0.7078
p.T10I	DO31090	OV	ICGC	PVTST	DEG_SPOP_SBC_1	0.7078
p.T10I	DO36556	READ	ICGC	PVTST	DEG_SPOP_SBC_1	0.7078
p.T10I	SIDM00516	Melanoma	GDSC	PVTST	DEG_SPOP_SBC_1	0.7078
p.T10I	ACH-002166	Skin Cancer	CCLE	PVTST	DEG_SPOP_SBC_1	0.7078
p.T10I	MZ7-mel	skin	COSMIC	PVTST	DEG_SPOP_SBC_1	0.7078
p.D16Y	TCGA-A5-A2K5	UCEC	TCGA	PVTST	DEG_SPOP_SBC_1	0.1667
p.D16Y	DO41379	UCEC	ICGC	PVTST	DEG_SPOP_SBC_1	0.1667
p.S5N	TCGA-EA-A410	CESC	TCGA	PVTST	DEG_SPOP_SBC_1	0.4167
p.S5N	DO49929	CESC	ICGC	PVTST	DEG_SPOP_SBC_1	0.4167
p.P4T	DO232224	PBCA	ICGC	PVTST	DEG_SPOP_SBC_1	0.2778
p.N19S	ACH-001991	Primary	CCLE	PVTST	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NCS4	Homeobox protein Nkx-2.6	DEG_SPOP_SBC_1	5:9	PVTST	SPOP	0.9836	More...
O75553	Disabled homolog 1	DEG_SPOP_SBC_1	504:508	PVTST	SPOP	0.9801	More...
O75554	WW domain-binding protein 4	DEG_SPOP_SBC_1	96:100	PVTST	SPOP	0.9878	More...
P22736	Nuclear receptor subfamily 4 group A member 1	DEG_SPOP_SBC_1	249:253	PVTST	SPOP	0.9805	More...
P49790	Nuclear pore complex protein Nup153	DEG_SPOP_SBC_1	1110:1114	PVTST	SPOP	0.9978	More...
P55197	Protein AF-10	DEG_SPOP_SBC_1	884:888	PVTST	SPOP	0.8239	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2221:2225	PVTST	SPOP	0.7357	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3327:3331	PVTST	SPOP	0.6584	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3625:3629	PVTST	SPOP	0.944	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	4058:4062	PVTST	SPOP	0.975	More...
Q13131	5'-AMP-activated protein kinase catalytic subunit alpha-1	DEG_SPOP_SBC_1	450:454	PVTST	SPOP	0.9471	More...
Q6NXT4	Zinc transporter 6	DEG_SPOP_SBC_1	372:376	PVTST	SPOP	0.9593	More...
Q6PL24	Protein TMED8	DEG_SPOP_SBC_1	225:229	PVTST	SPOP	0.9343	More...
Q6UN15	Pre-mRNA 3'-end-processing factor FIP1	DEG_SPOP_SBC_1	203:207	PVTST	SPOP	0.9115	More...
Q7Z7B0	Filamin-A-interacting protein 1	DEG_SPOP_SBC_1	799:803	PVTST	SPOP	0.9685	More...
Q8TAU0	Homeobox protein Nkx-2.3	DEG_SPOP_SBC_1	6:10	PVTST	SPOP	0.9861	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	12048:12052	PVTST	SPOP	0.6132	More...
Q99102	Mucin-4	DEG_SPOP_SBC_1	43:47	PVTST	SPOP	0.5365	More...
Q99102	Mucin-4	DEG_SPOP_SBC_1	1490:1494	PVTST	SPOP	0.9531	More...
Q9P2P6	StAR-related lipid transfer protein 9	DEG_SPOP_SBC_1	4244:4248	PVTST	SPOP	0.8399	More...
Q9UHY1	Nuclear receptor-binding protein	DEG_SPOP_SBC_1	33:37	PVTST	SPOP	0.6542	More...
Q9Y520	Protein PRRC2C	DEG_SPOP_SBC_1	2269:2273	PVTST	SPOP	0.9984	More...
Q5TID7	Coiled-coil domain-containing protein 181	DEG_SPOP_SBC_1	328:332	PVTST	SPOP	0.9574	More...
Q8IXQ8	PDZ domain-containing protein 9	DEG_SPOP_SBC_1	131:135	PVTST	SPOP	0.8501	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PVTST

Degron related mutations and impact score

Drug responses associated with NKX2-3 mutations

All proteins holding degron of PVTST