DegronMD - Q6UN15(FIP1L1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G242A	TCGA-04-1331	OV	TCGA	GRFNLFKVQ	DEG_APCC_DBOX_1	229:237	Mutation rewiring degron network	0.1944
p.G242A	DO28119	OV	ICGC	GRFNLFKVQ	DEG_APCC_DBOX_1	229:237	Mutation rewiring degron network	0.1944
p.R240I	TCGA-06-5416	GBM	TCGA	GRFNLFKVQ	DEG_APCC_DBOX_1	229:237	Mutation rewiring degron network	0.25
p.R240I	DO10880	GBM	ICGC	GRFNLFKVQ	DEG_APCC_DBOX_1	229:237	Mutation rewiring degron network	0.25
p.E225D	TCGA-21-5787	LUSC	TCGA	MEVTPGAE	DEG_SCF_FBW7_2	218:225	Mutation altering degron motif	0.6758
p.E225D	DO26605	LUSC	ICGC	MEVTPGAE	DEG_SCF_FBW7_2	218:225	Mutation altering degron motif	0.6758
p.S244L	TCGA-4E-A92E	UCEC	TCGA	GRFNLFKVQ	DEG_APCC_DBOX_1	229:237	Mutation blocking phosphorylation signal	0.5833
p.S244L	DO223277	UCEC	ICGC	GRFNLFKVQ	DEG_APCC_DBOX_1	229:237	Mutation blocking phosphorylation signal	0.5833
p.T208A	TCGA-55-7570	LUAD	TCGA	MEVTPGAE	DEG_SCF_FBW7_2	218:225	Mutation rewiring degron network	0.0556
p.T208A	TCGA-55-7570	LUAD	TCGA	PVTST	DEG_SPOP_SBC_1	203:207	Mutation rewiring degron network	0.3056
p.T208A	DO25280	LUAD	ICGC	MEVTPGAE	DEG_SCF_FBW7_2	218:225	Mutation rewiring degron network	0.0556
p.T208A	DO25280	LUAD	ICGC	PVTST	DEG_SPOP_SBC_1	203:207	Mutation rewiring degron network	0.3056
p.T207S	TCGA-67-4679	LUAD	TCGA	PVTST	DEG_SPOP_SBC_1	203:207	Mutation altering degron motif	0.6005
p.T207S	DO23604	LUAD	ICGC	PVTST	DEG_SPOP_SBC_1	203:207	Mutation altering degron motif	0.6005
p.L43I	TCGA-AX-A2HD	UCEC	TCGA	VHVHSD	LIG_APCC_ABBA_1	33:38	Mutation rewiring degron network	0.1944
p.L43I	DO42608	UCEC	ICGC	VHVHSD	LIG_APCC_ABBA_1	33:38	Mutation rewiring degron network	0.1944
p.T212M	TCGA-BR-8487	STAD	TCGA	MEVTPGAE	DEG_SCF_FBW7_2	218:225	Mutation rewiring degron network	0.1667
p.T212M	TCGA-BR-8487	STAD	TCGA	PVTST	DEG_SPOP_SBC_1	203:207	Mutation rewiring degron network	0.1944
p.T212M	TCGA-FI-A2D5	UCEC	TCGA	MEVTPGAE	DEG_SCF_FBW7_2	218:225	Mutation rewiring degron network	0.1667
p.T212M	TCGA-FI-A2D5	UCEC	TCGA	PVTST	DEG_SPOP_SBC_1	203:207	Mutation rewiring degron network	0.1944
p.T212M	DO47867	STAD	ICGC	MEVTPGAE	DEG_SCF_FBW7_2	218:225	Mutation rewiring degron network	0.1667
p.T212M	DO47867	STAD	ICGC	PVTST	DEG_SPOP_SBC_1	203:207	Mutation rewiring degron network	0.1944
p.T212M	DO41331	UCEC	ICGC	MEVTPGAE	DEG_SCF_FBW7_2	218:225	Mutation rewiring degron network	0.1667
p.T212M	DO41331	UCEC	ICGC	PVTST	DEG_SPOP_SBC_1	203:207	Mutation rewiring degron network	0.1944
p.R196Q	TCGA-D1-A17Q	UCEC	TCGA	PVTST	DEG_SPOP_SBC_1	203:207	Mutation rewiring degron network	0.1389
p.R196Q	DO41903	UCEC	ICGC	PVTST	DEG_SPOP_SBC_1	203:207	Mutation rewiring degron network	0.1389
p.V33L	DO225360	BRCA	ICGC	VHVHSD	LIG_APCC_ABBA_1	33:38	Mutation altering degron motif	0.5654
p.I195T	DO222576	COCA	ICGC	PVTST	DEG_SPOP_SBC_1	203:207	Mutation rewiring degron network	0.1111
p.L39F	DO228976	LICA	ICGC	VHVHSD	LIG_APCC_ABBA_1	33:38	Mutation rewiring degron network	0.3056
p.D32Y	DO229026	LICA	ICGC	VHVHSD	LIG_APCC_ABBA_1	33:38	Mutation rewiring degron network	0.3056
p.W31L	DO229035	LICA	ICGC	VHVHSD	LIG_APCC_ABBA_1	33:38	Mutation rewiring degron network	0.2778
p.G229V	DO229038	LICA	ICGC	GRFNLFKVQ	DEG_APCC_DBOX_1	229:237	Mutation altering degron motif	0.6421
p.I202M	DO229211	THCA	ICGC	PVTST	DEG_SPOP_SBC_1	203:207	Mutation rewiring degron network	0.3056
p.W25C	SIDM02059	Colorectal Carcinoma	GDSC	VHVHSD	LIG_APCC_ABBA_1	33:38	Mutation rewiring degron network	0.1111
p.N232S	SIDM00491	Thyroid Gland Carcinoma	GDSC	GRFNLFKVQ	DEG_APCC_DBOX_1	229:237	Mutation altering degron motif	0.5958
p.N232S	SIDM00465	Ovarian Carcinoma	GDSC	GRFNLFKVQ	DEG_APCC_DBOX_1	229:237	Mutation altering degron motif	0.5958
p.N232S	SIDM01172	Acute Myeloid Leukemia	GDSC	GRFNLFKVQ	DEG_APCC_DBOX_1	229:237	Mutation altering degron motif	0.5958
p.N232S	SIDM00237	Non-Small Cell Lung Carcinoma	GDSC	GRFNLFKVQ	DEG_APCC_DBOX_1	229:237	Mutation altering degron motif	0.5958
p.N232S	SIDM00306	Non-Small Cell Lung Carcinoma	GDSC	GRFNLFKVQ	DEG_APCC_DBOX_1	229:237	Mutation altering degron motif	0.5958
p.N232S	SIDM00448	B-Cell Non-Hodgkin's Lymphoma	GDSC	GRFNLFKVQ	DEG_APCC_DBOX_1	229:237	Mutation altering degron motif	0.5958
p.N232S	SIDM01460	Glioma	GDSC	GRFNLFKVQ	DEG_APCC_DBOX_1	229:237	Mutation altering degron motif	0.5958
p.S37G	SIDM00534	Colorectal Carcinoma	GDSC	VHVHSD	LIG_APCC_ABBA_1	33:38	Mutation altering degron motif	0.6993
p.S37G	ACH-000986	Colon/Colorectal Cancer	CCLE	VHVHSD	LIG_APCC_ABBA_1	33:38	Mutation altering degron motif	0.6993
p.S37G	HT-115	large intestine	COSMIC	VHVHSD	LIG_APCC_ABBA_1	33:38	Mutation altering degron motif	0.6993
p.V33M	ACH-001414	Bladder Cancer	CCLE	VHVHSD	LIG_APCC_ABBA_1	33:38	Mutation altering degron motif	0.6097
p.A224T	ACH-001518	Endometrial/Uterine Cancer	CCLE	MEVTPGAE	DEG_SCF_FBW7_2	218:225	Mutation altering degron motif	0.6028
p.T228P	ESS-1	endometrium	COSMIC	GRFNLFKVQ	DEG_APCC_DBOX_1	229:237	Mutation rewiring degron network	0.3056
p.T228P	ESS-1	endometrium	COSMIC	MEVTPGAE	DEG_SCF_FBW7_2	218:225	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FIP1L1

UniProt ID: Q6UN15

Entrez ID: 81608

Protein name: Pre-mRNA 3'-end-processing factor FIP1 (hFip1) (FIP1-like 1 protein) (Factor interacting with PAP) (Rearranged in hypereosinophilia)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FIP1L1 in