DegronMD - Q6UN15(FIP1L1)

FUNCTION: Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. FIP1L1 contributes to poly(A) site recognition and stimulates poly(A) addition. Binds to U-rich RNA sequence elements surrounding the poly(A) site. May act to tether poly(A) polymerase to the CPSF complex. {ECO:0000269|PubMed:14749727}.

GO - Biological processes (BP): mRNA polyadenylation [GO:0006378]; pre-mRNA cleavage required for polyadenylation [GO:0098789]

GO - Molecular function (MF): RNA binding [GO:0003723]

GO - Cellular component (CC): cytosol [GO:0005829]; mRNA cleavage and polyadenylation specificity factor complex [GO:0005847]; nucleoplasm [GO:0005654]

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Degron hit	Class	E3 ligase	Source protein	Location	Detail
GRFNLFKVQ	DEG_APCC_DBOX_1	APC,CDC20,FZR1	Pre-mRNA 3'-end-processing factor FIP1	229:237	More..
MEVTPGAE	DEG_SCF_FBW7_2	FBXW7	Pre-mRNA 3'-end-processing factor FIP1	218:225	More..
PVTST	DEG_SPOP_SBC_1	SPOP	Pre-mRNA 3'-end-processing factor FIP1	203:207	More..
VHVHSD	LIG_APCC_ABBA_1	APC,CDC20,FZR1	Pre-mRNA 3'-end-processing factor FIP1	33:38	More..

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S37G	SIDM00534	Colorectal Carcinoma	GDSC	VHVHSD	LIG_APCC_ABBA_1	33:38	Mutation altering degron motif	0.6993
p.S37G	ACH-000986	Colon/Colorectal Cancer	CCLE	VHVHSD	LIG_APCC_ABBA_1	33:38	Mutation altering degron motif	0.6993
p.S37G	HT-115	large intestine	COSMIC	VHVHSD	LIG_APCC_ABBA_1	33:38	Mutation altering degron motif	0.6993
p.E225D	TCGA-21-5787	LUSC	TCGA	MEVTPGAE	DEG_SCF_FBW7_2	218:225	Mutation altering degron motif	0.6758
p.E225D	DO26605	LUSC	ICGC	MEVTPGAE	DEG_SCF_FBW7_2	218:225	Mutation altering degron motif	0.6758
p.G229V	DO229038	LICA	ICGC	GRFNLFKVQ	DEG_APCC_DBOX_1	229:237	Mutation altering degron motif	0.6421
p.V33M	ACH-001414	Bladder Cancer	CCLE	VHVHSD	LIG_APCC_ABBA_1	33:38	Mutation altering degron motif	0.6097
p.A224T	ACH-001518	Endometrial/Uterine Cancer	CCLE	MEVTPGAE	DEG_SCF_FBW7_2	218:225	Mutation altering degron motif	0.6028
p.T207S	TCGA-67-4679	LUAD	TCGA	PVTST	DEG_SPOP_SBC_1	203:207	Mutation altering degron motif	0.6005
p.T207S	DO23604	LUAD	ICGC	PVTST	DEG_SPOP_SBC_1	203:207	Mutation altering degron motif	0.6005
p.N232S	SIDM00491	Thyroid Gland Carcinoma	GDSC	GRFNLFKVQ	DEG_APCC_DBOX_1	229:237	Mutation altering degron motif	0.5958
p.N232S	SIDM00465	Ovarian Carcinoma	GDSC	GRFNLFKVQ	DEG_APCC_DBOX_1	229:237	Mutation altering degron motif	0.5958
p.N232S	SIDM01172	Acute Myeloid Leukemia	GDSC	GRFNLFKVQ	DEG_APCC_DBOX_1	229:237	Mutation altering degron motif	0.5958
p.N232S	SIDM00237	Non-Small Cell Lung Carcinoma	GDSC	GRFNLFKVQ	DEG_APCC_DBOX_1	229:237	Mutation altering degron motif	0.5958
p.N232S	SIDM00306	Non-Small Cell Lung Carcinoma	GDSC	GRFNLFKVQ	DEG_APCC_DBOX_1	229:237	Mutation altering degron motif	0.5958
p.N232S	SIDM00448	B-Cell Non-Hodgkin's Lymphoma	GDSC	GRFNLFKVQ	DEG_APCC_DBOX_1	229:237	Mutation altering degron motif	0.5958
p.N232S	SIDM01460	Glioma	GDSC	GRFNLFKVQ	DEG_APCC_DBOX_1	229:237	Mutation altering degron motif	0.5958
p.S244L	TCGA-4E-A92E	UCEC	TCGA	GRFNLFKVQ	DEG_APCC_DBOX_1	229:237	Mutation blocking phosphorylation signal	0.5833
p.S244L	DO223277	UCEC	ICGC	GRFNLFKVQ	DEG_APCC_DBOX_1	229:237	Mutation blocking phosphorylation signal	0.5833
p.V33L	DO225360	BRCA	ICGC	VHVHSD	LIG_APCC_ABBA_1	33:38	Mutation altering degron motif	0.5654

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No resistance data available for this Degron.

Kaplan plot for FIP1L1 in

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

FIP1L1

UniProt ID: Q6UN15

Entrez ID: 81608

Protein name: Pre-mRNA 3'-end-processing factor FIP1 (hFip1) (FIP1-like 1 protein) (Factor interacting with PAP) (Rearranged in hypereosinophilia)

External links: UniprotKB HGNC RefSeq COSMIC

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No resistance data available for this Degron.

Kaplan plot for FIP1L1 in