DegronMD

Uniprot ID: Q6UN15

Source protein: Pre-mRNA 3'-end-processing factor FIP1

Source gene: FIP1L1

Class: DEG_APCC_DBOX_1

Location: 229:237

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8652

ASA_SCORE: 87.1111

COIL: 0.6022

CONS_SCORE: 0.3348

DSS_SCORE: 0.5185

HELIX: 0.2758

FCONS_SCORE: 1.2157

RIG_SCORE: 0.8177

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G242A	TCGA-04-1331	OV	TCGA	GRFNLFKVQ	DEG_APCC_DBOX_1	0.1944
p.G242A	DO28119	OV	ICGC	GRFNLFKVQ	DEG_APCC_DBOX_1	0.1944
p.R240I	TCGA-06-5416	GBM	TCGA	GRFNLFKVQ	DEG_APCC_DBOX_1	0.25
p.R240I	DO10880	GBM	ICGC	GRFNLFKVQ	DEG_APCC_DBOX_1	0.25
p.S244L	TCGA-4E-A92E	UCEC	TCGA	GRFNLFKVQ	DEG_APCC_DBOX_1	0.5833
p.S244L	DO223277	UCEC	ICGC	GRFNLFKVQ	DEG_APCC_DBOX_1	0.5833
p.G229V	DO229038	LICA	ICGC	GRFNLFKVQ	DEG_APCC_DBOX_1	0.6421
p.N232S	SIDM00491	Thyroid Gland Carcinoma	GDSC	GRFNLFKVQ	DEG_APCC_DBOX_1	0.5958
p.N232S	SIDM00465	Ovarian Carcinoma	GDSC	GRFNLFKVQ	DEG_APCC_DBOX_1	0.5958
p.N232S	SIDM01172	Acute Myeloid Leukemia	GDSC	GRFNLFKVQ	DEG_APCC_DBOX_1	0.5958
p.N232S	SIDM00237	Non-Small Cell Lung Carcinoma	GDSC	GRFNLFKVQ	DEG_APCC_DBOX_1	0.5958
p.N232S	SIDM00306	Non-Small Cell Lung Carcinoma	GDSC	GRFNLFKVQ	DEG_APCC_DBOX_1	0.5958
p.N232S	SIDM00448	B-Cell Non-Hodgkin's Lymphoma	GDSC	GRFNLFKVQ	DEG_APCC_DBOX_1	0.5958
p.N232S	SIDM01460	Glioma	GDSC	GRFNLFKVQ	DEG_APCC_DBOX_1	0.5958
p.T228P	ESS-1	endometrium	COSMIC	GRFNLFKVQ	DEG_APCC_DBOX_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6UN15	Pre-mRNA 3'-end-processing factor FIP1	DEG_APCC_DBOX_1	229:237	GRFNLFKVQ	APC,CDC20,FZR1	0.8652	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons