DegronMD

Uniprot ID: Q6UN15

Source protein: Pre-mRNA 3'-end-processing factor FIP1

Source gene: FIP1L1

Class: DEG_SCF_FBW7_2

Location: 218:225

E3 ligase: FBXW7

DEGRON score: 0.9944

ASA_SCORE: 75.025

COIL: 0.8719

CONS_SCORE: 0.2188

DSS_SCORE: 0.449

HELIX: 0.0665

FCONS_SCORE: 0.7397

RIG_SCORE: 0.8045

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E225D	TCGA-21-5787	LUSC	TCGA	MEVTPGAE	DEG_SCF_FBW7_2	0.6758
p.E225D	DO26605	LUSC	ICGC	MEVTPGAE	DEG_SCF_FBW7_2	0.6758
p.T208A	TCGA-55-7570	LUAD	TCGA	MEVTPGAE	DEG_SCF_FBW7_2	0.0556
p.T208A	DO25280	LUAD	ICGC	MEVTPGAE	DEG_SCF_FBW7_2	0.0556
p.T212M	TCGA-BR-8487	STAD	TCGA	MEVTPGAE	DEG_SCF_FBW7_2	0.1667
p.T212M	TCGA-FI-A2D5	UCEC	TCGA	MEVTPGAE	DEG_SCF_FBW7_2	0.1667
p.T212M	DO47867	STAD	ICGC	MEVTPGAE	DEG_SCF_FBW7_2	0.1667
p.T212M	DO41331	UCEC	ICGC	MEVTPGAE	DEG_SCF_FBW7_2	0.1667
p.A224T	ACH-001518	Endometrial/Uterine Cancer	CCLE	MEVTPGAE	DEG_SCF_FBW7_2	0.6028
p.T228P	ESS-1	endometrium	COSMIC	MEVTPGAE	DEG_SCF_FBW7_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6UN15	Pre-mRNA 3'-end-processing factor FIP1	DEG_SCF_FBW7_2	218:225	MEVTPGAE	FBXW7	0.9944	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons