DegronMD

Uniprot ID: Q6UN15

Source protein: Pre-mRNA 3'-end-processing factor FIP1

Source gene: FIP1L1

Class: LIG_APCC_ABBA_1

Location: 33:38

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7976

ASA_SCORE: 90.9667

COIL: 0.5968

CONS_SCORE: 0.3214

DSS_SCORE: 0.4924

HELIX: 0.375

FCONS_SCORE: 0.7689

RIG_SCORE: 0.7947

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L43I	TCGA-AX-A2HD	UCEC	TCGA	VHVHSD	LIG_APCC_ABBA_1	0.1944
p.L43I	DO42608	UCEC	ICGC	VHVHSD	LIG_APCC_ABBA_1	0.1944
p.V33L	DO225360	BRCA	ICGC	VHVHSD	LIG_APCC_ABBA_1	0.5654
p.L39F	DO228976	LICA	ICGC	VHVHSD	LIG_APCC_ABBA_1	0.3056
p.D32Y	DO229026	LICA	ICGC	VHVHSD	LIG_APCC_ABBA_1	0.3056
p.W31L	DO229035	LICA	ICGC	VHVHSD	LIG_APCC_ABBA_1	0.2778
p.W25C	SIDM02059	Colorectal Carcinoma	GDSC	VHVHSD	LIG_APCC_ABBA_1	0.1111
p.S37G	SIDM00534	Colorectal Carcinoma	GDSC	VHVHSD	LIG_APCC_ABBA_1	0.6993
p.S37G	ACH-000986	Colon/Colorectal Cancer	CCLE	VHVHSD	LIG_APCC_ABBA_1	0.6993
p.S37G	HT-115	large_intestine	COSMIC	VHVHSD	LIG_APCC_ABBA_1	0.6993
p.V33M	ACH-001414	Bladder Cancer	CCLE	VHVHSD	LIG_APCC_ABBA_1	0.6097

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6UN15	Pre-mRNA 3'-end-processing factor FIP1	LIG_APCC_ABBA_1	33:38	VHVHSD	APC,CDC20,FZR1	0.7976	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons