DegronMD - Q8IXQ8(PDZD9)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.I122T	TCGA-22-4604	LUSC	TCGA	PVTST	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.0833
p.I122T	DO26922	LUSC	ICGC	PVTST	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.0833
p.D141Y	TCGA-EI-6917	READ	TCGA	PVTST	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.1667
p.D141Y	DO36881	READ	ICGC	PVTST	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.1667
p.S121C	TCGA-L5-A43E	ESCA	TCGA	PVTST	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.0556
p.G139E	TCGA-OD-A75X	SKCM	TCGA	PVTST	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.2222
p.G139E	DO48601	SKCM	ICGC	PVTST	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.2222
p.D141G	TCGA-XR-A8TG	LIHC	TCGA	PVTST	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.1667
p.D141G	DO223040	ESCA	ICGC	PVTST	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.1667
p.D141G	DO223924	LIHC	ICGC	PVTST	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.1667
p.G128E	DO234406	ESAD	ICGC	PVTST	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.25
p.H127N	DO229009	LICA	ICGC	PVTST	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.2222
p.Y129C	SIDM00779	Colorectal Carcinoma	GDSC	PVTST	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.2778
p.Y129C	NCI-H716	large intestine	COSMIC	PVTST	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.2778
p.K213E	ACH-000392	Lung Cancer	CCLE	VMIHRD	LIG_APCC_ABBA_1	206:211	Mutation rewiring degron network	0.2778
p.K213E	Calu-3	lung	COSMIC	VMIHRD	LIG_APCC_ABBA_1	206:211	Mutation rewiring degron network	0.2778

Kaplan plot for PDZD9 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PDZD9

UniProt ID: Q8IXQ8

Entrez ID: 255762

Protein name: PDZ domain-containing protein 9

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PDZD9 in