DegronMD: protein-targeted degradation, mutation and drug response to degrons
Home
(current)
Browse
Proteins/Degrons
Mutations
Drug response
Network-rewiring
Drug resistance
Search
Tutorial
Download
Contact
Links
BSML
CPH
CGC
Degron:
VMIHRD
Uniprot ID:
Q8IXQ8
Source protein:
PDZ domain-containing protein 9
Source gene:
PDZD9
Class:
LIG_APCC_ABBA_1
Location:
206:211
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.6233
ASA_SCORE:
68.5667
COIL:
0.5712
CONS_SCORE:
0.8536
DSS_SCORE:
0.4216
HELIX:
0.0515
FCONS_SCORE:
1.0154
RIG_SCORE:
0.8526
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.K213E
ACH-000392
Lung Cancer
CCLE
VMIHRD
LIG_APCC_ABBA_1
0.2778
p.K213E
Calu-3
lung
COSMIC
VMIHRD
LIG_APCC_ABBA_1
0.2778
Drug responses associated with PDZD9 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VMIHRD
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8IXQ8
PDZ domain-containing protein 9
LIG_APCC_ABBA_1
206:211
VMIHRD
APC,CDC20,FZR1
0.6233
More...