DegronMD

Uniprot ID: Q8IXQ8

Source protein: PDZ domain-containing protein 9

Source gene: PDZD9

Class: DEG_SPOP_SBC_1

Location: 131:135

E3 ligase: SPOP

DEGRON score: 0.8501

ASA_SCORE: 87.78

COIL: 0.9534

CONS_SCORE: 0.7408

DSS_SCORE: 0.2791

HELIX: 0.0186

FCONS_SCORE: 0.9916

RIG_SCORE: 0.7629

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Y129C	SIDM00779	Colorectal Carcinoma	GDSC	PVTST	DEG_SPOP_SBC_1	0.2778
p.Y129C	NCI-H716	large_intestine	COSMIC	PVTST	DEG_SPOP_SBC_1	0.2778
p.G128E	DO234406	ESAD	ICGC	PVTST	DEG_SPOP_SBC_1	0.25
p.G139E	TCGA-OD-A75X	SKCM	TCGA	PVTST	DEG_SPOP_SBC_1	0.2222
p.G139E	DO48601	SKCM	ICGC	PVTST	DEG_SPOP_SBC_1	0.2222
p.H127N	DO229009	LICA	ICGC	PVTST	DEG_SPOP_SBC_1	0.2222
p.D141Y	TCGA-EI-6917	READ	TCGA	PVTST	DEG_SPOP_SBC_1	0.1667
p.D141Y	DO36881	READ	ICGC	PVTST	DEG_SPOP_SBC_1	0.1667
p.D141G	TCGA-XR-A8TG	LIHC	TCGA	PVTST	DEG_SPOP_SBC_1	0.1667
p.D141G	DO223040	ESCA	ICGC	PVTST	DEG_SPOP_SBC_1	0.1667
p.D141G	DO223924	LIHC	ICGC	PVTST	DEG_SPOP_SBC_1	0.1667
p.I122T	TCGA-22-4604	LUSC	TCGA	PVTST	DEG_SPOP_SBC_1	0.0833
p.I122T	DO26922	LUSC	ICGC	PVTST	DEG_SPOP_SBC_1	0.0833
p.S121C	TCGA-L5-A43E	ESCA	TCGA	PVTST	DEG_SPOP_SBC_1	0.0556

Showing 1 to 14 of 14 entries

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Drug responses associated with PDZD9 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of PVTST

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13131	5'-AMP-activated protein kinase catalytic subunit alpha-1	DEG_SPOP_SBC_1	450:454	PVTST	SPOP	0.9471	More...
Q5TID7	Coiled-coil domain-containing protein 181	DEG_SPOP_SBC_1	328:332	PVTST	SPOP	0.9574	More...
O75553	Disabled homolog 1	DEG_SPOP_SBC_1	504:508	PVTST	SPOP	0.9801	More...
Q7Z7B0	Filamin-A-interacting protein 1	DEG_SPOP_SBC_1	799:803	PVTST	SPOP	0.9685	More...
Q8TAU0	Homeobox protein Nkx-2.3	DEG_SPOP_SBC_1	6:10	PVTST	SPOP	0.9861	More...
A6NCS4	Homeobox protein Nkx-2.6	DEG_SPOP_SBC_1	5:9	PVTST	SPOP	0.9836	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	12048:12052	PVTST	SPOP	0.6132	More...
Q99102	Mucin-4	DEG_SPOP_SBC_1	43:47	PVTST	SPOP	0.5365	More...
Q99102	Mucin-4	DEG_SPOP_SBC_1	1490:1494	PVTST	SPOP	0.9531	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2221:2225	PVTST	SPOP	0.7357	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3327:3331	PVTST	SPOP	0.6584	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3625:3629	PVTST	SPOP	0.944	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	4058:4062	PVTST	SPOP	0.975	More...
P49790	Nuclear pore complex protein Nup153	DEG_SPOP_SBC_1	1110:1114	PVTST	SPOP	0.9978	More...
P22736	Nuclear receptor subfamily 4 group A member 1	DEG_SPOP_SBC_1	249:253	PVTST	SPOP	0.9805	More...
Q9UHY1	Nuclear receptor-binding protein	DEG_SPOP_SBC_1	33:37	PVTST	SPOP	0.6542	More...
Q8IXQ8	PDZ domain-containing protein 9	DEG_SPOP_SBC_1	131:135	PVTST	SPOP	0.8501	More...
Q6UN15	Pre-mRNA 3'-end-processing factor FIP1	DEG_SPOP_SBC_1	203:207	PVTST	SPOP	0.9115	More...
P55197	Protein AF-10	DEG_SPOP_SBC_1	884:888	PVTST	SPOP	0.8239	More...
Q9Y520	Protein PRRC2C	DEG_SPOP_SBC_1	2269:2273	PVTST	SPOP	0.9984	More...
Q6PL24	Protein TMED8	DEG_SPOP_SBC_1	225:229	PVTST	SPOP	0.9343	More...
Q9P2P6	StAR-related lipid transfer protein 9	DEG_SPOP_SBC_1	4244:4248	PVTST	SPOP	0.8399	More...
O75554	WW domain-binding protein 4	DEG_SPOP_SBC_1	96:100	PVTST	SPOP	0.9878	More...
Q6NXT4	Zinc transporter 6	DEG_SPOP_SBC_1	372:376	PVTST	SPOP	0.9593	More...

Showing 1 to 24 of 24 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PVTST

Degron related mutations and impact score

Drug responses associated with PDZD9 mutations

All proteins holding degron of PVTST