DegronMD

Uniprot ID: Q13131

Source protein: 5'-AMP-activated protein kinase catalytic subunit alpha-1

Source gene: PRKAA1

Class: DEG_SPOP_SBC_1

Location: 450:454

E3 ligase: SPOP

DEGRON score: 0.9471

ASA_SCORE: 87.26

COIL: 0.8356

CONS_SCORE: 0.2428

DSS_SCORE: 0.1891

HELIX: 0.0268

FCONS_SCORE: 0.6616

RIG_SCORE: 0.7908

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K451T	TCGA-2H-A9GF	ESCA	TCGA	PVTST	DEG_SPOP_SBC_1	0.7306
p.W450R	TCGA-2W-A8YY	CESC	TCGA	PVTST	DEG_SPOP_SBC_1	0.8634
p.R459C	TCGA-D1-A17S	UCEC	TCGA	PVTST	DEG_SPOP_SBC_1	0.1944
p.R459C	SIDM00777	Colorectal Carcinoma	GDSC	PVTST	DEG_SPOP_SBC_1	0.1944
p.R459C	NCI-H508	large_intestine	COSMIC	PVTST	DEG_SPOP_SBC_1	0.1944
p.R459H	TCGA-EO-A22T	UCEC	TCGA	PVTST	DEG_SPOP_SBC_1	0.1944
p.K448N	DO232761	PBCA	ICGC	PVTST	DEG_SPOP_SBC_1	0.7222
p.Q464K	DO50279	SKCM	ICGC	PVTST	DEG_SPOP_SBC_1	0.0556
p.R444H	DO42320	UCEC	ICGC	PVTST	DEG_SPOP_SBC_1	0.1667
p.S453I	DO43186	UCEC	ICGC	PVTST	DEG_SPOP_SBC_1	0.7341
p.R444C	DO41313	UCEC	ICGC	PVTST	DEG_SPOP_SBC_1	0.1667
p.R444C	ACH-000360	Colon/Colorectal Cancer	CCLE	PVTST	DEG_SPOP_SBC_1	0.1667
p.R444C	NCI-H508	large_intestine	COSMIC	PVTST	DEG_SPOP_SBC_1	0.1667
p.R462M	SIDM00135	Breast Carcinoma	GDSC	PVTST	DEG_SPOP_SBC_1	0.1111
p.R462M	Hs-578-T	breast	COSMIC	PVTST	DEG_SPOP_SBC_1	0.1111
p.K444R	SIDM00573	Glioblastoma	GDSC	PVTST	DEG_SPOP_SBC_1	0.1667
p.K444R	SIDM00592	Oral Cavity Carcinoma	GDSC	PVTST	DEG_SPOP_SBC_1	0.1667
p.K444R	SIDM01093	Cervical Carcinoma	GDSC	PVTST	DEG_SPOP_SBC_1	0.1667
p.K444R	SIDM00494	Non-Small Cell Lung Carcinoma	GDSC	PVTST	DEG_SPOP_SBC_1	0.1667
p.K444R	SIDM00604	Oral Cavity Carcinoma	GDSC	PVTST	DEG_SPOP_SBC_1	0.1667
p.K444R	SIDM01729	Endometrial Carcinoma	GDSC	PVTST	DEG_SPOP_SBC_1	0.1667
p.R447M	ACH-000148	Breast Cancer	CCLE	PVTST	DEG_SPOP_SBC_1	0.25
p.R447M	Hs-578-T	breast	COSMIC	PVTST	DEG_SPOP_SBC_1	0.25
p.P450A	ACH-000595	Brain Cancer	CCLE	PVTST	DEG_SPOP_SBC_1	0.6392
p.P450A	LN-229	central_nervous_system	COSMIC	PVTST	DEG_SPOP_SBC_1	0.6392
p.S453N	ACH-000985	Colon/Colorectal Cancer	CCLE	PVTST	DEG_SPOP_SBC_1	0.7069
p.S453N	LS-411N	large_intestine	COSMIC	PVTST	DEG_SPOP_SBC_1	0.7069
p.Q461R	ACH-000996	Endometrial/Uterine Cancer	CCLE	PVTST	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NCS4	Homeobox protein Nkx-2.6	DEG_SPOP_SBC_1	5:9	PVTST	SPOP	0.9836	More...
O75553	Disabled homolog 1	DEG_SPOP_SBC_1	504:508	PVTST	SPOP	0.9801	More...
O75554	WW domain-binding protein 4	DEG_SPOP_SBC_1	96:100	PVTST	SPOP	0.9878	More...
P22736	Nuclear receptor subfamily 4 group A member 1	DEG_SPOP_SBC_1	249:253	PVTST	SPOP	0.9805	More...
P49790	Nuclear pore complex protein Nup153	DEG_SPOP_SBC_1	1110:1114	PVTST	SPOP	0.9978	More...
P55197	Protein AF-10	DEG_SPOP_SBC_1	884:888	PVTST	SPOP	0.8239	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2221:2225	PVTST	SPOP	0.7357	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3327:3331	PVTST	SPOP	0.6584	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3625:3629	PVTST	SPOP	0.944	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	4058:4062	PVTST	SPOP	0.975	More...
Q13131	5'-AMP-activated protein kinase catalytic subunit alpha-1	DEG_SPOP_SBC_1	450:454	PVTST	SPOP	0.9471	More...
Q6NXT4	Zinc transporter 6	DEG_SPOP_SBC_1	372:376	PVTST	SPOP	0.9593	More...
Q6PL24	Protein TMED8	DEG_SPOP_SBC_1	225:229	PVTST	SPOP	0.9343	More...
Q6UN15	Pre-mRNA 3'-end-processing factor FIP1	DEG_SPOP_SBC_1	203:207	PVTST	SPOP	0.9115	More...
Q7Z7B0	Filamin-A-interacting protein 1	DEG_SPOP_SBC_1	799:803	PVTST	SPOP	0.9685	More...
Q8TAU0	Homeobox protein Nkx-2.3	DEG_SPOP_SBC_1	6:10	PVTST	SPOP	0.9861	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	12048:12052	PVTST	SPOP	0.6132	More...
Q99102	Mucin-4	DEG_SPOP_SBC_1	43:47	PVTST	SPOP	0.5365	More...
Q99102	Mucin-4	DEG_SPOP_SBC_1	1490:1494	PVTST	SPOP	0.9531	More...
Q9P2P6	StAR-related lipid transfer protein 9	DEG_SPOP_SBC_1	4244:4248	PVTST	SPOP	0.8399	More...
Q9UHY1	Nuclear receptor-binding protein	DEG_SPOP_SBC_1	33:37	PVTST	SPOP	0.6542	More...
Q9Y520	Protein PRRC2C	DEG_SPOP_SBC_1	2269:2273	PVTST	SPOP	0.9984	More...
Q5TID7	Coiled-coil domain-containing protein 181	DEG_SPOP_SBC_1	328:332	PVTST	SPOP	0.9574	More...
Q8IXQ8	PDZ domain-containing protein 9	DEG_SPOP_SBC_1	131:135	PVTST	SPOP	0.8501	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PVTST

Degron related mutations and impact score

Drug responses associated with PRKAA1 mutations

All proteins holding degron of PVTST