DegronMD - Q8TAU0(NKX2-3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T10I	TCGA-24-1471	OV	TCGA	PVTST	DEG_SPOP_SBC_1	6:10	Mutation altering degron motif	0.7078
p.T10I	TCGA-F5-6814	READ	TCGA	PVTST	DEG_SPOP_SBC_1	6:10	Mutation altering degron motif	0.7078
p.T10I	DO31090	OV	ICGC	PVTST	DEG_SPOP_SBC_1	6:10	Mutation altering degron motif	0.7078
p.T10I	DO36556	READ	ICGC	PVTST	DEG_SPOP_SBC_1	6:10	Mutation altering degron motif	0.7078
p.T10I	SIDM00516	Melanoma	GDSC	PVTST	DEG_SPOP_SBC_1	6:10	Mutation altering degron motif	0.7078
p.T10I	ACH-002166	Skin Cancer	CCLE	PVTST	DEG_SPOP_SBC_1	6:10	Mutation altering degron motif	0.7078
p.T10I	MZ7-mel	skin	COSMIC	PVTST	DEG_SPOP_SBC_1	6:10	Mutation altering degron motif	0.7078
p.D16Y	TCGA-A5-A2K5	UCEC	TCGA	PVTST	DEG_SPOP_SBC_1	6:10	Mutation rewiring degron network	0.1667
p.D16Y	DO41379	UCEC	ICGC	PVTST	DEG_SPOP_SBC_1	6:10	Mutation rewiring degron network	0.1667
p.S5N	TCGA-EA-A410	CESC	TCGA	PVTST	DEG_SPOP_SBC_1	6:10	Mutation substituting flanking lysine	0.4167
p.S5N	DO49929	CESC	ICGC	PVTST	DEG_SPOP_SBC_1	6:10	Mutation substituting flanking lysine	0.4167
p.P4T	DO232224	PBCA	ICGC	PVTST	DEG_SPOP_SBC_1	6:10	Mutation rewiring degron network	0.2778
p.N19S	ACH-001991	Primary	CCLE	PVTST	DEG_SPOP_SBC_1	6:10	Mutation rewiring degron network	0.0833

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons