DegronMD

Uniprot ID: Q5TID7

Source protein: Coiled-coil domain-containing protein 181

Source gene: CCDC181

Class: DEG_SPOP_SBC_1

Location: 328:332

E3 ligase: SPOP

DEGRON score: 0.9574

ASA_SCORE: 67.72

COIL: 0.8294

CONS_SCORE: 0.4767

DSS_SCORE: 0.5922

HELIX: 0.121

FCONS_SCORE: 0.8218

RIG_SCORE: 0.6906

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T330I	TCGA-AP-A051	UCEC	TCGA	PVTST	DEG_SPOP_SBC_1	0.7078
p.T330I	DO42673	UCEC	ICGC	PVTST	DEG_SPOP_SBC_1	0.7078
p.S336F	TCGA-D3-A8GI	SKCM	TCGA	PVTST	DEG_SPOP_SBC_1	0.2222
p.S336F	DO50284	SKCM	ICGC	PVTST	DEG_SPOP_SBC_1	0.2222
p.R338Q	TCGA-Q9-A6FW	ESCA	TCGA	PVTST	DEG_SPOP_SBC_1	0.1667
p.R338Q	DO229489	LAML	ICGC	PVTST	DEG_SPOP_SBC_1	0.1667
p.R338Q	SIDM00614	Hepatocellular Carcinoma	GDSC	PVTST	DEG_SPOP_SBC_1	0.1667
p.R338Q	SIDM01038	B-Cell Non-Hodgkin's Lymphoma	GDSC	PVTST	DEG_SPOP_SBC_1	0.1667
p.R338Q	SIDM01032	Esophageal Squamous Cell Carcinoma	GDSC	PVTST	DEG_SPOP_SBC_1	0.1667
p.R338Q	SIDM00294	Small Cell Lung Carcinoma	GDSC	PVTST	DEG_SPOP_SBC_1	0.1667
p.R338Q	SIDM00298	Squamous Cell Lung Carcinoma	GDSC	PVTST	DEG_SPOP_SBC_1	0.1667
p.R338Q	SIDM00997	Thyroid Gland Carcinoma	GDSC	PVTST	DEG_SPOP_SBC_1	0.1667
p.R338Q	SIDM00970	Bladder Carcinoma	GDSC	PVTST	DEG_SPOP_SBC_1	0.1667
p.R338Q	SIDM00018	Acute Myeloid Leukemia	GDSC	PVTST	DEG_SPOP_SBC_1	0.1667
p.R338Q	SIDM01217	Other Blood Cancers	GDSC	PVTST	DEG_SPOP_SBC_1	0.1667
p.R338Q	SIDM00900	Non-Cancerous	GDSC	PVTST	DEG_SPOP_SBC_1	0.1667
p.R338Q	SIDM00448	B-Cell Non-Hodgkin's Lymphoma	GDSC	PVTST	DEG_SPOP_SBC_1	0.1667
p.R338Q	SIDM01695	Acute Myeloid Leukemia	GDSC	PVTST	DEG_SPOP_SBC_1	0.1667
p.R338Q	SIDM01582	Gastric Carcinoma	GDSC	PVTST	DEG_SPOP_SBC_1	0.1667
p.R338Q	SIDM01511	Gastric Carcinoma	GDSC	PVTST	DEG_SPOP_SBC_1	0.1667
p.Q322K	DO229027	LICA	ICGC	PVTST	DEG_SPOP_SBC_1	0.1667
p.H319N	DO229032	LICA	ICGC	PVTST	DEG_SPOP_SBC_1	0.0833
p.H319R	SIDM02059	Colorectal Carcinoma	GDSC	PVTST	DEG_SPOP_SBC_1	0.0833
p.T332A	SIDM00336	Melanoma	GDSC	PVTST	DEG_SPOP_SBC_1	0.7139
p.T332A	SIDM00942	Oral Cavity Carcinoma	GDSC	PVTST	DEG_SPOP_SBC_1	0.7139
p.P337L	SIDM00153	T-Lymphoblastic Leukemia	GDSC	PVTST	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NCS4	Homeobox protein Nkx-2.6	DEG_SPOP_SBC_1	5:9	PVTST	SPOP	0.9836	More...
O75553	Disabled homolog 1	DEG_SPOP_SBC_1	504:508	PVTST	SPOP	0.9801	More...
O75554	WW domain-binding protein 4	DEG_SPOP_SBC_1	96:100	PVTST	SPOP	0.9878	More...
P22736	Nuclear receptor subfamily 4 group A member 1	DEG_SPOP_SBC_1	249:253	PVTST	SPOP	0.9805	More...
P49790	Nuclear pore complex protein Nup153	DEG_SPOP_SBC_1	1110:1114	PVTST	SPOP	0.9978	More...
P55197	Protein AF-10	DEG_SPOP_SBC_1	884:888	PVTST	SPOP	0.8239	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2221:2225	PVTST	SPOP	0.7357	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3327:3331	PVTST	SPOP	0.6584	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3625:3629	PVTST	SPOP	0.944	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	4058:4062	PVTST	SPOP	0.975	More...
Q13131	5'-AMP-activated protein kinase catalytic subunit alpha-1	DEG_SPOP_SBC_1	450:454	PVTST	SPOP	0.9471	More...
Q6NXT4	Zinc transporter 6	DEG_SPOP_SBC_1	372:376	PVTST	SPOP	0.9593	More...
Q6PL24	Protein TMED8	DEG_SPOP_SBC_1	225:229	PVTST	SPOP	0.9343	More...
Q6UN15	Pre-mRNA 3'-end-processing factor FIP1	DEG_SPOP_SBC_1	203:207	PVTST	SPOP	0.9115	More...
Q7Z7B0	Filamin-A-interacting protein 1	DEG_SPOP_SBC_1	799:803	PVTST	SPOP	0.9685	More...
Q8TAU0	Homeobox protein Nkx-2.3	DEG_SPOP_SBC_1	6:10	PVTST	SPOP	0.9861	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	12048:12052	PVTST	SPOP	0.6132	More...
Q99102	Mucin-4	DEG_SPOP_SBC_1	43:47	PVTST	SPOP	0.5365	More...
Q99102	Mucin-4	DEG_SPOP_SBC_1	1490:1494	PVTST	SPOP	0.9531	More...
Q9P2P6	StAR-related lipid transfer protein 9	DEG_SPOP_SBC_1	4244:4248	PVTST	SPOP	0.8399	More...
Q9UHY1	Nuclear receptor-binding protein	DEG_SPOP_SBC_1	33:37	PVTST	SPOP	0.6542	More...
Q9Y520	Protein PRRC2C	DEG_SPOP_SBC_1	2269:2273	PVTST	SPOP	0.9984	More...
Q5TID7	Coiled-coil domain-containing protein 181	DEG_SPOP_SBC_1	328:332	PVTST	SPOP	0.9574	More...
Q8IXQ8	PDZ domain-containing protein 9	DEG_SPOP_SBC_1	131:135	PVTST	SPOP	0.8501	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PVTST

Degron related mutations and impact score

Drug responses associated with CCDC181 mutations

All proteins holding degron of PVTST