DegronMD - O75554(WBP4)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L83F	TCGA-B5-A3FA	UCEC	TCGA	PSITPVTS	DEG_SCF_FBW7_1	92:99	Mutation rewiring degron network	0.0833
p.S189F	TCGA-EB-A431	SKCM	TCGA	NTETGE	DEG_Kelch_Keap1_1	183:188	Mutation rewiring degron network	0.3056
p.E192D	TCGA-MA-AA41	CESC	TCGA	NTETGE	DEG_Kelch_Keap1_1	183:188	Mutation rewiring degron network	0.2222
p.D101A	DO9346	COAD	ICGC	PSITPVTS	DEG_SCF_FBW7_1	92:99	Mutation rewiring degron network	0.2778
p.D101A	DO9346	COAD	ICGC	PVTST	DEG_SPOP_SBC_1	96:100	Mutation rewiring degron network	0.3056
p.V188F	DO228976	LICA	ICGC	NTETGE	DEG_Kelch_Keap1_1	183:188	Mutation altering degron motif	0.7068
p.V188F	DO229037	LICA	ICGC	NTETGE	DEG_Kelch_Keap1_1	183:188	Mutation altering degron motif	0.7068
p.G194V	DO229027	LICA	ICGC	NTETGE	DEG_Kelch_Keap1_1	183:188	Mutation rewiring degron network	0.1667
p.E198K	DO33042	PACA	ICGC	NTETGE	DEG_Kelch_Keap1_1	183:188	Mutation rewiring degron network	0.0556
p.D101Y	DO36881	READ	ICGC	PSITPVTS	DEG_SCF_FBW7_1	92:99	Mutation rewiring degron network	0.2778
p.D101Y	DO36881	READ	ICGC	PVTST	DEG_SPOP_SBC_1	96:100	Mutation rewiring degron network	0.3056
p.S103L	DO47807	STAD	ICGC	PSITPVTS	DEG_SCF_FBW7_1	92:99	Mutation rewiring degron network	0.2222
p.S103L	DO47807	STAD	ICGC	PVTST	DEG_SPOP_SBC_1	96:100	Mutation rewiring degron network	0.25
p.K92Q	DO222378	STAD	ICGC	PSITPVTS	DEG_SCF_FBW7_1	92:99	Mutation altering degron motif	0.6944
p.S192L	DO43434	UCEC	ICGC	NTETGE	DEG_Kelch_Keap1_1	183:188	Mutation rewiring degron network	0.2222
p.P102H	DO42280	UCEC	ICGC	PSITPVTS	DEG_SCF_FBW7_1	92:99	Mutation rewiring degron network	0.25
p.P102H	DO42280	UCEC	ICGC	PVTST	DEG_SPOP_SBC_1	96:100	Mutation rewiring degron network	0.2778
p.P92S	SIDM00118	Colorectal Carcinoma	GDSC	PSITPVTS	DEG_SCF_FBW7_1	92:99	Mutation altering degron motif	0.6752
p.P92S	ACH-001081	Colon/Colorectal Cancer	CCLE	PSITPVTS	DEG_SCF_FBW7_1	92:99	Mutation altering degron motif	0.6752
p.P92S	HCC2998	large intestine	COSMIC	PSITPVTS	DEG_SCF_FBW7_1	92:99	Mutation altering degron motif	0.6752
p.T106P	ACH-000941	Endometrial/Uterine Cancer	CCLE	PSITPVTS	DEG_SCF_FBW7_1	92:99	Mutation blocking phosphorylation signal	0.5833
p.T106P	ACH-000941	Endometrial/Uterine Cancer	CCLE	PVTST	DEG_SPOP_SBC_1	96:100	Mutation blocking phosphorylation signal	0.6111
p.R82K	ACH-001172	Brain Cancer	CCLE	PSITPVTS	DEG_SCF_FBW7_1	92:99	Mutation rewiring degron network	0.0556
p.R82K	ACH-002197	Lung Cancer	CCLE	PSITPVTS	DEG_SCF_FBW7_1	92:99	Mutation rewiring degron network	0.0556

Kaplan plot for WBP4 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

WBP4

UniProt ID: O75554

Entrez ID: 11193

Protein name: WW domain-binding protein 4 (WBP-4) (Formin-binding protein 21) (WW domain-containing-binding protein 4)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for WBP4 in