DegronMD

Uniprot ID: O75554

Source protein: WW domain-binding protein 4

Source gene: WBP4

Class: DEG_Kelch_Keap1_1

Location: 183:188

E3 ligase: KEAP1

DEGRON score: 0.9935

ASA_SCORE: 73.2167

COIL: 0.8157

CONS_SCORE: 0.6548

DSS_SCORE: 0.3644

HELIX: 0.0297

FCONS_SCORE: 1.0429

RIG_SCORE: 0.7723

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S189F	TCGA-EB-A431	SKCM	TCGA	NTETGE	DEG_Kelch_Keap1_1	0.3056
p.E192D	TCGA-MA-AA41	CESC	TCGA	NTETGE	DEG_Kelch_Keap1_1	0.2222
p.V188F	DO228976	LICA	ICGC	NTETGE	DEG_Kelch_Keap1_1	0.7068
p.V188F	DO229037	LICA	ICGC	NTETGE	DEG_Kelch_Keap1_1	0.7068
p.G194V	DO229027	LICA	ICGC	NTETGE	DEG_Kelch_Keap1_1	0.1667
p.E198K	DO33042	PACA	ICGC	NTETGE	DEG_Kelch_Keap1_1	0.0556
p.S192L	DO43434	UCEC	ICGC	NTETGE	DEG_Kelch_Keap1_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75554	WW domain-binding protein 4	DEG_Kelch_Keap1_1	183:188	NTETGE	KEAP1	0.9935	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons