DegronMD

Uniprot ID: O75554

Source protein: WW domain-binding protein 4

Source gene: WBP4

Class: DEG_SCF_FBW7_1

Location: 92:99

E3 ligase: FBXW7

DEGRON score: 0.9982

ASA_SCORE: 66.85

COIL: 0.8326

CONS_SCORE: 0.46

DSS_SCORE: 0.5629

HELIX: 0.06

FCONS_SCORE: 1.0635

RIG_SCORE: 0.6741

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L83F	TCGA-B5-A3FA	UCEC	TCGA	PSITPVTS	DEG_SCF_FBW7_1	0.0833
p.D101A	DO9346	COAD	ICGC	PSITPVTS	DEG_SCF_FBW7_1	0.2778
p.D101Y	DO36881	READ	ICGC	PSITPVTS	DEG_SCF_FBW7_1	0.2778
p.S103L	DO47807	STAD	ICGC	PSITPVTS	DEG_SCF_FBW7_1	0.2222
p.K92Q	DO222378	STAD	ICGC	PSITPVTS	DEG_SCF_FBW7_1	0.6944
p.P102H	DO42280	UCEC	ICGC	PSITPVTS	DEG_SCF_FBW7_1	0.25
p.P92S	SIDM00118	Colorectal Carcinoma	GDSC	PSITPVTS	DEG_SCF_FBW7_1	0.6752
p.P92S	ACH-001081	Colon/Colorectal Cancer	CCLE	PSITPVTS	DEG_SCF_FBW7_1	0.6752
p.P92S	HCC2998	large_intestine	COSMIC	PSITPVTS	DEG_SCF_FBW7_1	0.6752
p.T106P	ACH-000941	Endometrial/Uterine Cancer	CCLE	PSITPVTS	DEG_SCF_FBW7_1	0.5833
p.R82K	ACH-001172	Brain Cancer	CCLE	PSITPVTS	DEG_SCF_FBW7_1	0.0556
p.R82K	ACH-002197	Lung Cancer	CCLE	PSITPVTS	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75554	WW domain-binding protein 4	DEG_SCF_FBW7_1	92:99	PSITPVTS	FBXW7	0.9982	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons