DegronMD - Q7Z7B0(FILIP1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q222K	TCGA-25-2398	OV	TCGA	ERERLKKLL	DEG_APCC_DBOX_1	207:215	Mutation rewiring degron network	0.1389
p.V1039D	TCGA-AA-3947	COAD	TCGA	TPEKQTVPTP	DEG_COP1_1	1040:1049	Mutation rewiring degron network	0.3056
p.S1127I	TCGA-AA-A010	COAD	TCGA	ITITPVTT	DEG_SCF_FBW7_1	1129:1136	Mutation rewiring degron network	0.2778
p.S1127I	TCGA-AA-A010	COAD	TCGA	PVTTS	DEG_SPOP_SBC_1	1133:1137	Mutation rewiring degron network	0.1667
p.Q1044K	TCGA-AB-2849	LAML	TCGA	TPEKQTVPTP	DEG_COP1_1	1040:1049	Mutation altering degron motif	0.5833
p.V796A	TCGA-AP-A051	UCEC	TCGA	PVTST	DEG_SPOP_SBC_1	799:803	Mutation rewiring degron network	0.25
p.G804V	TCGA-AX-A2H7	UCEC	TCGA	PVTST	DEG_SPOP_SBC_1	799:803	Mutation rewiring degron network	0.3056
p.Q1143R	TCGA-AX-A2HD	UCEC	TCGA	ITITPVTT	DEG_SCF_FBW7_1	1129:1136	Mutation rewiring degron network	0.1389
p.Q1143R	TCGA-AX-A2HD	UCEC	TCGA	PVTTS	DEG_SPOP_SBC_1	1133:1137	Mutation rewiring degron network	0.1667
p.Y1053H	TCGA-B5-A11H	UCEC	TCGA	TPEKQTVPTP	DEG_COP1_1	1040:1049	Mutation blocking phosphorylation signal	0.6667
p.E209K	TCGA-B5-A11R	UCEC	TCGA	ERERLKKLL	DEG_APCC_DBOX_1	207:215	Mutation altering degron motif	0.591
p.V790A	TCGA-B5-A3FA	UCEC	TCGA	PVTST	DEG_SPOP_SBC_1	799:803	Mutation rewiring degron network	0.0833
p.R208W	TCGA-B5-A3FA	UCEC	TCGA	ERERLKKLL	DEG_APCC_DBOX_1	207:215	Mutation altering degron motif	0.8634
p.D199N	TCGA-B5-A3FA	UCEC	TCGA	ERERLKKLL	DEG_APCC_DBOX_1	207:215	Mutation rewiring degron network	0.1111
p.D199N	TCGA-EE-A2GH	SKCM	TCGA	ERERLKKLL	DEG_APCC_DBOX_1	207:215	Mutation rewiring degron network	0.1111
p.D199N	TCGA-EO-A22U	UCEC	TCGA	ERERLKKLL	DEG_APCC_DBOX_1	207:215	Mutation rewiring degron network	0.1111
p.R1034W	TCGA-C5-A1MK	CESC	TCGA	TPEKQTVPTP	DEG_COP1_1	1040:1049	Mutation rewiring degron network	0.1667
p.R1034W	SIDM00146	Breast Carcinoma	GDSC	TPEKQTVPTP	DEG_COP1_1	1040:1049	Mutation rewiring degron network	0.1667
p.R1034W	ACH-000768	Breast Cancer	CCLE	TPEKQTVPTP	DEG_COP1_1	1040:1049	Mutation rewiring degron network	0.1667
p.R1034W	MDA-MB-231	breast	COSMIC	TPEKQTVPTP	DEG_COP1_1	1040:1049	Mutation rewiring degron network	0.1667
p.K1043I	TCGA-CA-6717	COAD	TCGA	TPEKQTVPTP	DEG_COP1_1	1040:1049	Mutation altering degron motif	0.642
p.E207Q	TCGA-DK-A3WW	BLCA	TCGA	ERERLKKLL	DEG_APCC_DBOX_1	207:215	Mutation altering degron motif	0.5633
p.R1034Q	TCGA-EB-A41A	SKCM	TCGA	TPEKQTVPTP	DEG_COP1_1	1040:1049	Mutation rewiring degron network	0.1667
p.R1140L	TCGA-EE-A181	SKCM	TCGA	ITITPVTT	DEG_SCF_FBW7_1	1129:1136	Mutation rewiring degron network	0.2222
p.R1140L	TCGA-EE-A181	SKCM	TCGA	PVTTS	DEG_SPOP_SBC_1	1133:1137	Mutation rewiring degron network	0.25
p.P1041S	TCGA-EE-A29M	SKCM	TCGA	TPEKQTVPTP	DEG_COP1_1	1040:1049	Mutation altering degron motif	0.5641
p.R1034L	TCGA-EE-A3AD	SKCM	TCGA	TPEKQTVPTP	DEG_COP1_1	1040:1049	Mutation rewiring degron network	0.1667
p.T801M	TCGA-F5-6464	READ	TCGA	PVTST	DEG_SPOP_SBC_1	799:803	Mutation altering degron motif	0.7423
p.M795I	TCGA-FR-A726	SKCM	TCGA	PVTST	DEG_SPOP_SBC_1	799:803	Mutation rewiring degron network	0.2222
p.D198N	TCGA-FW-A3R5	SKCM	TCGA	ERERLKKLL	DEG_APCC_DBOX_1	207:215	Mutation rewiring degron network	0.0833
p.D198N	SIDM00534	Colorectal Carcinoma	GDSC	ERERLKKLL	DEG_APCC_DBOX_1	207:215	Mutation rewiring degron network	0.0833
p.D198N	ACH-000986	Colon/Colorectal Cancer	CCLE	ERERLKKLL	DEG_APCC_DBOX_1	207:215	Mutation rewiring degron network	0.0833
p.D198N	HT-115	large intestine	COSMIC	ERERLKKLL	DEG_APCC_DBOX_1	207:215	Mutation rewiring degron network	0.0833
p.P1120A	TCGA-OR-A5J4	ACC	TCGA	ITITPVTT	DEG_SCF_FBW7_1	1129:1136	Mutation rewiring degron network	0.0833
p.R1140Q	TCGA-UF-A7JO	HNSC	TCGA	ITITPVTT	DEG_SCF_FBW7_1	1129:1136	Mutation rewiring degron network	0.2222
p.R1140Q	TCGA-UF-A7JO	HNSC	TCGA	PVTTS	DEG_SPOP_SBC_1	1133:1137	Mutation rewiring degron network	0.25
p.T807S	TCGA-VQ-A91K	STAD	TCGA	PVTST	DEG_SPOP_SBC_1	799:803	Mutation blocking phosphorylation signal	0.6667
p.M1032K	TCGA-VQ-A91N	STAD	TCGA	TPEKQTVPTP	DEG_COP1_1	1040:1049	Mutation rewiring degron network	0.1111
p.P1133L	TCGA-XF-A9SW	BLCA	TCGA	ITITPVTT	DEG_SCF_FBW7_1	1129:1136	Mutation altering degron motif	0.7582
p.P1133L	TCGA-XF-A9SW	BLCA	TCGA	PVTTS	DEG_SPOP_SBC_1	1133:1137	Mutation altering degron motif	0.7582
p.P1034L	DO51915	BLCA	ICGC	TPEKQTVPTP	DEG_COP1_1	1040:1049	Mutation rewiring degron network	0.1667
p.P789S	DO219003	BLCA	ICGC	PVTST	DEG_SPOP_SBC_1	799:803	Mutation rewiring degron network	0.0556
p.R1041G	DO44273	BRCA	ICGC	TPEKQTVPTP	DEG_COP1_1	1040:1049	Mutation altering degron motif	0.7568
p.N792S	DO50091	COAD	ICGC	PVTST	DEG_SPOP_SBC_1	799:803	Mutation rewiring degron network	0.1389
p.R790Q	DO227709	COCA	ICGC	PVTST	DEG_SPOP_SBC_1	799:803	Mutation rewiring degron network	0.0833
p.R790Q	DO51274	SKCM	ICGC	PVTST	DEG_SPOP_SBC_1	799:803	Mutation rewiring degron network	0.0833
p.R790Q	DO41758	UCEC	ICGC	PVTST	DEG_SPOP_SBC_1	799:803	Mutation rewiring degron network	0.0833
p.L803I	DO222798	COCA	ICGC	PVTST	DEG_SPOP_SBC_1	799:803	Mutation altering degron motif	0.7174
p.R1055W	DO222306	DLBC	ICGC	TPEKQTVPTP	DEG_COP1_1	1040:1049	Mutation rewiring degron network	0.1667
p.R1055W	DO219225	LUSC	ICGC	TPEKQTVPTP	DEG_COP1_1	1040:1049	Mutation rewiring degron network	0.1667
p.E217V	DO234193	ESAD	ICGC	ERERLKKLL	DEG_APCC_DBOX_1	207:215	Mutation rewiring degron network	0.2778
p.R1041Q	DO219088	HNSC	ICGC	TPEKQTVPTP	DEG_COP1_1	1040:1049	Mutation altering degron motif	0.7329
p.S212F	DO228827	LICA	ICGC	ERERLKKLL	DEG_APCC_DBOX_1	207:215	Mutation altering degron motif	0.7982
p.P789H	DO229036	LICA	ICGC	PVTST	DEG_SPOP_SBC_1	799:803	Mutation rewiring degron network	0.0556
p.T791K	DO229045	LICA	ICGC	PVTST	DEG_SPOP_SBC_1	799:803	Mutation rewiring degron network	0.1111
p.R1055G	DO23846	LUAD	ICGC	TPEKQTVPTP	DEG_COP1_1	1040:1049	Mutation rewiring degron network	0.1667
p.S1052L	DO24900	LUAD	ICGC	TPEKQTVPTP	DEG_COP1_1	1040:1049	Mutation substituting flanking lysine	0.3611
p.M218I	DO223725	LUSC	ICGC	ERERLKKLL	DEG_APCC_DBOX_1	207:215	Mutation rewiring degron network	0.25
p.M218I	DO43682	UCEC	ICGC	ERERLKKLL	DEG_APCC_DBOX_1	207:215	Mutation rewiring degron network	0.25
p.G796R	DO222635	MELA	ICGC	PVTST	DEG_SPOP_SBC_1	799:803	Mutation rewiring degron network	0.25
p.G796R	DO37406	SKCM	ICGC	PVTST	DEG_SPOP_SBC_1	799:803	Mutation rewiring degron network	0.25
p.G796R	DO37443	SKCM	ICGC	PVTST	DEG_SPOP_SBC_1	799:803	Mutation rewiring degron network	0.25
p.L197F	DO232905	PEME	ICGC	ERERLKKLL	DEG_APCC_DBOX_1	207:215	Mutation rewiring degron network	0.0556
p.D203N	DO219878	SKCA	ICGC	ERERLKKLL	DEG_APCC_DBOX_1	207:215	Mutation rewiring degron network	0.2222
p.R210K	DO37555	SKCM	ICGC	ERERLKKLL	DEG_APCC_DBOX_1	207:215	Mutation altering degron motif	0.6126
p.S794G	DO37419	SKCM	ICGC	PVTST	DEG_SPOP_SBC_1	799:803	Mutation rewiring degron network	0.1944
p.R1041L	DO37444	SKCM	ICGC	TPEKQTVPTP	DEG_COP1_1	1040:1049	Mutation altering degron motif	0.8428
p.P810L	DO47337	SKCM	ICGC	PVTST	DEG_SPOP_SBC_1	799:803	Mutation rewiring degron network	0.1389
p.Q1044R	DO42608	UCEC	ICGC	TPEKQTVPTP	DEG_COP1_1	1040:1049	Mutation altering degron motif	0.6218
p.G796W	DO42713	UCEC	ICGC	PVTST	DEG_SPOP_SBC_1	799:803	Mutation rewiring degron network	0.25
p.K213R	SIDM00689	B-Lymphoblastic Leukemia	GDSC	ERERLKKLL	DEG_APCC_DBOX_1	207:215	Mutation altering degron motif	0.6126
p.K213R	ACH-000151	Leukemia	CCLE	ERERLKKLL	DEG_APCC_DBOX_1	207:215	Mutation altering degron motif	0.6126
p.K213R	JM1	haematopoietic and lymphoid tissue	COSMIC	ERERLKKLL	DEG_APCC_DBOX_1	207:215	Mutation altering degron motif	0.6126
p.R208P	SIDM00697	Small Cell Lung Carcinoma	GDSC	ERERLKKLL	DEG_APCC_DBOX_1	207:215	Mutation altering degron motif	0.7512
p.R208P	ACH-000830	Lung Cancer	CCLE	ERERLKKLL	DEG_APCC_DBOX_1	207:215	Mutation altering degron motif	0.7512
p.R208P	NCI-H1436	lung	COSMIC	ERERLKKLL	DEG_APCC_DBOX_1	207:215	Mutation altering degron motif	0.7512
p.T1126M	SIDM00846	Cervical Carcinoma	GDSC	ITITPVTT	DEG_SCF_FBW7_1	1129:1136	Mutation rewiring degron network	0.25
p.T1126M	SIDM00846	Cervical Carcinoma	GDSC	PVTTS	DEG_SPOP_SBC_1	1133:1137	Mutation rewiring degron network	0.1389
p.T1126M	SIDM00203	Ewing's Sarcoma	GDSC	ITITPVTT	DEG_SCF_FBW7_1	1129:1136	Mutation rewiring degron network	0.25
p.T1126M	SIDM00203	Ewing's Sarcoma	GDSC	PVTTS	DEG_SPOP_SBC_1	1133:1137	Mutation rewiring degron network	0.1389
p.T1126M	SIDM00014	Colorectal Carcinoma	GDSC	ITITPVTT	DEG_SCF_FBW7_1	1129:1136	Mutation rewiring degron network	0.25
p.T1126M	SIDM00014	Colorectal Carcinoma	GDSC	PVTTS	DEG_SPOP_SBC_1	1133:1137	Mutation rewiring degron network	0.1389
p.T1126M	SIDM00539	Esophageal Carcinoma	GDSC	ITITPVTT	DEG_SCF_FBW7_1	1129:1136	Mutation rewiring degron network	0.25
p.T1126M	SIDM00539	Esophageal Carcinoma	GDSC	PVTTS	DEG_SPOP_SBC_1	1133:1137	Mutation rewiring degron network	0.1389
p.T1126M	SIDM00379	Glioma	GDSC	ITITPVTT	DEG_SCF_FBW7_1	1129:1136	Mutation rewiring degron network	0.25
p.T1126M	SIDM00379	Glioma	GDSC	PVTTS	DEG_SPOP_SBC_1	1133:1137	Mutation rewiring degron network	0.1389
p.V798A	SIDM01007	T-Lymphoblastic Leukemia	GDSC	PVTST	DEG_SPOP_SBC_1	799:803	Mutation rewiring degron network	0.3056
p.V798A	ACH-002256	Leukemia	CCLE	PVTST	DEG_SPOP_SBC_1	799:803	Mutation rewiring degron network	0.3056
p.V798A	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	PVTST	DEG_SPOP_SBC_1	799:803	Mutation rewiring degron network	0.3056
p.R208Q	SIDM00596	Endometrial Carcinoma	GDSC	ERERLKKLL	DEG_APCC_DBOX_1	207:215	Mutation altering degron motif	0.7329
p.R208Q	ACH-001517	Endometrial/Uterine Cancer	CCLE	ERERLKKLL	DEG_APCC_DBOX_1	207:215	Mutation altering degron motif	0.7329
p.R208Q	HEC-1	endometrium	COSMIC	ERERLKKLL	DEG_APCC_DBOX_1	207:215	Mutation altering degron motif	0.7329
p.D797Y	SIDM00888	Other Solid Cancers	GDSC	PVTST	DEG_SPOP_SBC_1	799:803	Mutation rewiring degron network	0.2778
p.D797Y	ACH-000055	Brain Cancer	CCLE	PVTST	DEG_SPOP_SBC_1	799:803	Mutation rewiring degron network	0.2778
p.D797Y	D-283MED	central nervous system	COSMIC	PVTST	DEG_SPOP_SBC_1	799:803	Mutation rewiring degron network	0.2778
p.V805I	SIDM00841	Colorectal Carcinoma	GDSC	PVTST	DEG_SPOP_SBC_1	799:803	Mutation rewiring degron network	0.2778
p.V805I	SW620	large intestine	COSMIC	PVTST	DEG_SPOP_SBC_1	799:803	Mutation rewiring degron network	0.2778
p.K1052E	SIDM01102	Non-Cancerous	GDSC	TPEKQTVPTP	DEG_COP1_1	1040:1049	Mutation substituting flanking lysine	0.3611
p.K1052E	ACH-002316	Non-Cancerous	CCLE	TPEKQTVPTP	DEG_COP1_1	1040:1049	Mutation substituting flanking lysine	0.3611
p.K1052E	WIL2-NS	haematopoietic and lymphoid tissue	COSMIC	TPEKQTVPTP	DEG_COP1_1	1040:1049	Mutation substituting flanking lysine	0.3611
p.T1142I	ACH-001053	Brain Cancer	CCLE	ITITPVTT	DEG_SCF_FBW7_1	1129:1136	Mutation rewiring degron network	0.1667
p.T1142I	ACH-001053	Brain Cancer	CCLE	PVTTS	DEG_SPOP_SBC_1	1133:1137	Mutation rewiring degron network	0.1944
p.T1142I	ACH-001054	Brain Cancer	CCLE	ITITPVTT	DEG_SCF_FBW7_1	1129:1136	Mutation rewiring degron network	0.1667
p.T1142I	ACH-001054	Brain Cancer	CCLE	PVTTS	DEG_SPOP_SBC_1	1133:1137	Mutation rewiring degron network	0.1944
p.E813K	ACH-001982	Metastasis	CCLE	PVTST	DEG_SPOP_SBC_1	799:803	Mutation rewiring degron network	0.0556
p.M218K	GI-ME-N	autonomic ganglia	COSMIC	ERERLKKLL	DEG_APCC_DBOX_1	207:215	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FILIP1

UniProt ID: Q7Z7B0

Entrez ID: 27145

Protein name: Filamin-A-interacting protein 1 (FILIP)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FILIP1 in