DegronMD

Uniprot ID: Q7Z7B0

Source protein: Filamin-A-interacting protein 1

Source gene: FILIP1

Class: DEG_COP1_1

Location: 1040:1049

E3 ligase: COP1

DEGRON score: 0.9626

ASA_SCORE: 91.26

COIL: 0.8729

CONS_SCORE: 0.4855

DSS_SCORE: 0.5237

HELIX: 0.0294

FCONS_SCORE: 0.9077

RIG_SCORE: 0.7405

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V1039D	TCGA-AA-3947	COAD	TCGA	TPEKQTVPTP	DEG_COP1_1	0.3056
p.Q1044K	TCGA-AB-2849	LAML	TCGA	TPEKQTVPTP	DEG_COP1_1	0.5833
p.Y1053H	TCGA-B5-A11H	UCEC	TCGA	TPEKQTVPTP	DEG_COP1_1	0.6667
p.R1034W	TCGA-C5-A1MK	CESC	TCGA	TPEKQTVPTP	DEG_COP1_1	0.1667
p.R1034W	SIDM00146	Breast Carcinoma	GDSC	TPEKQTVPTP	DEG_COP1_1	0.1667
p.R1034W	ACH-000768	Breast Cancer	CCLE	TPEKQTVPTP	DEG_COP1_1	0.1667
p.R1034W	MDA-MB-231	breast	COSMIC	TPEKQTVPTP	DEG_COP1_1	0.1667
p.K1043I	TCGA-CA-6717	COAD	TCGA	TPEKQTVPTP	DEG_COP1_1	0.642
p.R1034Q	TCGA-EB-A41A	SKCM	TCGA	TPEKQTVPTP	DEG_COP1_1	0.1667
p.P1041S	TCGA-EE-A29M	SKCM	TCGA	TPEKQTVPTP	DEG_COP1_1	0.5641
p.R1034L	TCGA-EE-A3AD	SKCM	TCGA	TPEKQTVPTP	DEG_COP1_1	0.1667
p.M1032K	TCGA-VQ-A91N	STAD	TCGA	TPEKQTVPTP	DEG_COP1_1	0.1111
p.P1034L	DO51915	BLCA	ICGC	TPEKQTVPTP	DEG_COP1_1	0.1667
p.R1041G	DO44273	BRCA	ICGC	TPEKQTVPTP	DEG_COP1_1	0.7568
p.R1055W	DO222306	DLBC	ICGC	TPEKQTVPTP	DEG_COP1_1	0.1667
p.R1055W	DO219225	LUSC	ICGC	TPEKQTVPTP	DEG_COP1_1	0.1667
p.R1041Q	DO219088	HNSC	ICGC	TPEKQTVPTP	DEG_COP1_1	0.7329
p.R1055G	DO23846	LUAD	ICGC	TPEKQTVPTP	DEG_COP1_1	0.1667
p.S1052L	DO24900	LUAD	ICGC	TPEKQTVPTP	DEG_COP1_1	0.3611
p.R1041L	DO37444	SKCM	ICGC	TPEKQTVPTP	DEG_COP1_1	0.8428
p.Q1044R	DO42608	UCEC	ICGC	TPEKQTVPTP	DEG_COP1_1	0.6218
p.K1052E	SIDM01102	Non-Cancerous	GDSC	TPEKQTVPTP	DEG_COP1_1	0.3611
p.K1052E	ACH-002316	Non-Cancerous	CCLE	TPEKQTVPTP	DEG_COP1_1	0.3611
p.K1052E	WIL2-NS	haematopoietic_and_lymphoid_tissue	COSMIC	TPEKQTVPTP	DEG_COP1_1	0.3611

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z7B0	Filamin-A-interacting protein 1	DEG_COP1_1	1040:1049	TPEKQTVPTP	COP1	0.9626	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons