DegronMD

Uniprot ID: Q7Z7B0

Source protein: Filamin-A-interacting protein 1

Source gene: FILIP1

Class: DEG_SCF_FBW7_1

Location: 1129:1136

E3 ligase: FBXW7

DEGRON score: 0.9837

ASA_SCORE: 73.375

COIL: 0.6636

CONS_SCORE: 0.6531

DSS_SCORE: 0.5763

HELIX: 0.0089

FCONS_SCORE: 1.2542

RIG_SCORE: 0.7445

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1127I	TCGA-AA-A010	COAD	TCGA	ITITPVTT	DEG_SCF_FBW7_1	0.2778
p.Q1143R	TCGA-AX-A2HD	UCEC	TCGA	ITITPVTT	DEG_SCF_FBW7_1	0.1389
p.R1140L	TCGA-EE-A181	SKCM	TCGA	ITITPVTT	DEG_SCF_FBW7_1	0.2222
p.P1120A	TCGA-OR-A5J4	ACC	TCGA	ITITPVTT	DEG_SCF_FBW7_1	0.0833
p.R1140Q	TCGA-UF-A7JO	HNSC	TCGA	ITITPVTT	DEG_SCF_FBW7_1	0.2222
p.P1133L	TCGA-XF-A9SW	BLCA	TCGA	ITITPVTT	DEG_SCF_FBW7_1	0.7582
p.T1126M	SIDM00846	Cervical Carcinoma	GDSC	ITITPVTT	DEG_SCF_FBW7_1	0.25
p.T1126M	SIDM00203	Ewing's Sarcoma	GDSC	ITITPVTT	DEG_SCF_FBW7_1	0.25
p.T1126M	SIDM00014	Colorectal Carcinoma	GDSC	ITITPVTT	DEG_SCF_FBW7_1	0.25
p.T1126M	SIDM00539	Esophageal Carcinoma	GDSC	ITITPVTT	DEG_SCF_FBW7_1	0.25
p.T1126M	SIDM00379	Glioma	GDSC	ITITPVTT	DEG_SCF_FBW7_1	0.25
p.T1142I	ACH-001053	Brain Cancer	CCLE	ITITPVTT	DEG_SCF_FBW7_1	0.1667
p.T1142I	ACH-001054	Brain Cancer	CCLE	ITITPVTT	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z7B0	Filamin-A-interacting protein 1	DEG_SCF_FBW7_1	1129:1136	ITITPVTT	FBXW7	0.9837	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons