DegronMD

Uniprot ID: Q7Z7B0

Source protein: Filamin-A-interacting protein 1

Source gene: FILIP1

Class: DEG_APCC_DBOX_1

Location: 207:215

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7337

ASA_SCORE: 105.1222

COIL: 0.0407

CONS_SCORE: 0.8714

DSS_SCORE: 0.4353

HELIX: 0.9607

FCONS_SCORE: 1.106

RIG_SCORE: 0.8025

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q222K	TCGA-25-2398	OV	TCGA	ERERLKKLL	DEG_APCC_DBOX_1	0.1389
p.E209K	TCGA-B5-A11R	UCEC	TCGA	ERERLKKLL	DEG_APCC_DBOX_1	0.591
p.R208W	TCGA-B5-A3FA	UCEC	TCGA	ERERLKKLL	DEG_APCC_DBOX_1	0.8634
p.D199N	TCGA-B5-A3FA	UCEC	TCGA	ERERLKKLL	DEG_APCC_DBOX_1	0.1111
p.D199N	TCGA-EE-A2GH	SKCM	TCGA	ERERLKKLL	DEG_APCC_DBOX_1	0.1111
p.D199N	TCGA-EO-A22U	UCEC	TCGA	ERERLKKLL	DEG_APCC_DBOX_1	0.1111
p.E207Q	TCGA-DK-A3WW	BLCA	TCGA	ERERLKKLL	DEG_APCC_DBOX_1	0.5633
p.D198N	TCGA-FW-A3R5	SKCM	TCGA	ERERLKKLL	DEG_APCC_DBOX_1	0.0833
p.D198N	SIDM00534	Colorectal Carcinoma	GDSC	ERERLKKLL	DEG_APCC_DBOX_1	0.0833
p.D198N	ACH-000986	Colon/Colorectal Cancer	CCLE	ERERLKKLL	DEG_APCC_DBOX_1	0.0833
p.D198N	HT-115	large_intestine	COSMIC	ERERLKKLL	DEG_APCC_DBOX_1	0.0833
p.E217V	DO234193	ESAD	ICGC	ERERLKKLL	DEG_APCC_DBOX_1	0.2778
p.S212F	DO228827	LICA	ICGC	ERERLKKLL	DEG_APCC_DBOX_1	0.7982
p.M218I	DO223725	LUSC	ICGC	ERERLKKLL	DEG_APCC_DBOX_1	0.25
p.M218I	DO43682	UCEC	ICGC	ERERLKKLL	DEG_APCC_DBOX_1	0.25
p.L197F	DO232905	PEME	ICGC	ERERLKKLL	DEG_APCC_DBOX_1	0.0556
p.D203N	DO219878	SKCA	ICGC	ERERLKKLL	DEG_APCC_DBOX_1	0.2222
p.R210K	DO37555	SKCM	ICGC	ERERLKKLL	DEG_APCC_DBOX_1	0.6126
p.K213R	SIDM00689	B-Lymphoblastic Leukemia	GDSC	ERERLKKLL	DEG_APCC_DBOX_1	0.6126
p.K213R	ACH-000151	Leukemia	CCLE	ERERLKKLL	DEG_APCC_DBOX_1	0.6126
p.K213R	JM1	haematopoietic_and_lymphoid_tissue	COSMIC	ERERLKKLL	DEG_APCC_DBOX_1	0.6126
p.R208P	SIDM00697	Small Cell Lung Carcinoma	GDSC	ERERLKKLL	DEG_APCC_DBOX_1	0.7512
p.R208P	ACH-000830	Lung Cancer	CCLE	ERERLKKLL	DEG_APCC_DBOX_1	0.7512
p.R208P	NCI-H1436	lung	COSMIC	ERERLKKLL	DEG_APCC_DBOX_1	0.7512
p.R208Q	SIDM00596	Endometrial Carcinoma	GDSC	ERERLKKLL	DEG_APCC_DBOX_1	0.7329
p.R208Q	ACH-001517	Endometrial/Uterine Cancer	CCLE	ERERLKKLL	DEG_APCC_DBOX_1	0.7329
p.R208Q	HEC-1	endometrium	COSMIC	ERERLKKLL	DEG_APCC_DBOX_1	0.7329
p.M218K	GI-ME-N	autonomic_ganglia	COSMIC	ERERLKKLL	DEG_APCC_DBOX_1	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ERERLKKLL

Degron related mutations and impact score

Drug responses associated with FILIP1 mutations

All proteins holding degron of ERERLKKLL

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z7B0	Filamin-A-interacting protein 1	DEG_APCC_DBOX_1	207:215	ERERLKKLL	APC,CDC20,FZR1	0.7337	More...