DegronMD - Q5TID7(CCDC181)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T330I	TCGA-AP-A051	UCEC	TCGA	PVTST	DEG_SPOP_SBC_1	328:332	Mutation altering degron motif	0.7078
p.T330I	DO42673	UCEC	ICGC	PVTST	DEG_SPOP_SBC_1	328:332	Mutation altering degron motif	0.7078
p.S336F	TCGA-D3-A8GI	SKCM	TCGA	PVTST	DEG_SPOP_SBC_1	328:332	Mutation rewiring degron network	0.2222
p.S336F	DO50284	SKCM	ICGC	PVTST	DEG_SPOP_SBC_1	328:332	Mutation rewiring degron network	0.2222
p.R338Q	TCGA-Q9-A6FW	ESCA	TCGA	PVTST	DEG_SPOP_SBC_1	328:332	Mutation rewiring degron network	0.1667
p.R338Q	DO229489	LAML	ICGC	PVTST	DEG_SPOP_SBC_1	328:332	Mutation rewiring degron network	0.1667
p.R338Q	SIDM00614	Hepatocellular Carcinoma	GDSC	PVTST	DEG_SPOP_SBC_1	328:332	Mutation rewiring degron network	0.1667
p.R338Q	SIDM01038	B-Cell Non-Hodgkin's Lymphoma	GDSC	PVTST	DEG_SPOP_SBC_1	328:332	Mutation rewiring degron network	0.1667
p.R338Q	SIDM01032	Esophageal Squamous Cell Carcinoma	GDSC	PVTST	DEG_SPOP_SBC_1	328:332	Mutation rewiring degron network	0.1667
p.R338Q	SIDM00294	Small Cell Lung Carcinoma	GDSC	PVTST	DEG_SPOP_SBC_1	328:332	Mutation rewiring degron network	0.1667
p.R338Q	SIDM00298	Squamous Cell Lung Carcinoma	GDSC	PVTST	DEG_SPOP_SBC_1	328:332	Mutation rewiring degron network	0.1667
p.R338Q	SIDM00997	Thyroid Gland Carcinoma	GDSC	PVTST	DEG_SPOP_SBC_1	328:332	Mutation rewiring degron network	0.1667
p.R338Q	SIDM00970	Bladder Carcinoma	GDSC	PVTST	DEG_SPOP_SBC_1	328:332	Mutation rewiring degron network	0.1667
p.R338Q	SIDM00018	Acute Myeloid Leukemia	GDSC	PVTST	DEG_SPOP_SBC_1	328:332	Mutation rewiring degron network	0.1667
p.R338Q	SIDM01217	Other Blood Cancers	GDSC	PVTST	DEG_SPOP_SBC_1	328:332	Mutation rewiring degron network	0.1667
p.R338Q	SIDM00900	Non-Cancerous	GDSC	PVTST	DEG_SPOP_SBC_1	328:332	Mutation rewiring degron network	0.1667
p.R338Q	SIDM00448	B-Cell Non-Hodgkin's Lymphoma	GDSC	PVTST	DEG_SPOP_SBC_1	328:332	Mutation rewiring degron network	0.1667
p.R338Q	SIDM01695	Acute Myeloid Leukemia	GDSC	PVTST	DEG_SPOP_SBC_1	328:332	Mutation rewiring degron network	0.1667
p.R338Q	SIDM01582	Gastric Carcinoma	GDSC	PVTST	DEG_SPOP_SBC_1	328:332	Mutation rewiring degron network	0.1667
p.R338Q	SIDM01511	Gastric Carcinoma	GDSC	PVTST	DEG_SPOP_SBC_1	328:332	Mutation rewiring degron network	0.1667
p.Q322K	DO229027	LICA	ICGC	PVTST	DEG_SPOP_SBC_1	328:332	Mutation rewiring degron network	0.1667
p.H319N	DO229032	LICA	ICGC	PVTST	DEG_SPOP_SBC_1	328:332	Mutation rewiring degron network	0.0833
p.H319R	SIDM02059	Colorectal Carcinoma	GDSC	PVTST	DEG_SPOP_SBC_1	328:332	Mutation rewiring degron network	0.0833
p.T332A	SIDM00336	Melanoma	GDSC	PVTST	DEG_SPOP_SBC_1	328:332	Mutation altering degron motif	0.7139
p.T332A	SIDM00942	Oral Cavity Carcinoma	GDSC	PVTST	DEG_SPOP_SBC_1	328:332	Mutation altering degron motif	0.7139
p.P337L	SIDM00153	T-Lymphoblastic Leukemia	GDSC	PVTST	DEG_SPOP_SBC_1	328:332	Mutation rewiring degron network	0.1944

Kaplan plot for CCDC181 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CCDC181

UniProt ID: Q5TID7

Entrez ID: 57821

Protein name: Coiled-coil domain-containing protein 181

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CCDC181 in