DegronMD

Uniprot ID: Q99102

Source protein: Mucin-4

Source gene: MUC4

Class: DEG_SPOP_SBC_1

Location: 43:47

E3 ligase: SPOP

DEGRON score: 0.5365

ASA_SCORE: 93.24

COIL: 0.8178

CONS_SCORE: 0.3379

DSS_SCORE: 0.4848

HELIX: 0.0146

FCONS_SCORE: 1.1079

RIG_SCORE: 0.699

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G48C	TCGA-33-6738	LUSC	TCGA	PVTST	DEG_SPOP_SBC_1	0.3056
p.G48C	TCGA-B5-A3FC	UCEC	TCGA	PVTST	DEG_SPOP_SBC_1	0.3056
p.G48C	DO26516	LUSC	ICGC	PVTST	DEG_SPOP_SBC_1	0.3056
p.G48C	DO41871	UCEC	ICGC	PVTST	DEG_SPOP_SBC_1	0.3056
p.L34F	TCGA-B5-A0JY	UCEC	TCGA	PVTST	DEG_SPOP_SBC_1	0.0833
p.L34F	DO234377	ESAD	ICGC	PVTST	DEG_SPOP_SBC_1	0.0833
p.L34F	DO43041	UCEC	ICGC	PVTST	DEG_SPOP_SBC_1	0.0833
p.T36S	TCGA-DF-A2KV	UCEC	TCGA	PVTST	DEG_SPOP_SBC_1	0.1389
p.T36S	DO219771	UCEC	ICGC	PVTST	DEG_SPOP_SBC_1	0.1389
p.G48A	TCGA-FJ-A3Z7	BLCA	TCGA	PVTST	DEG_SPOP_SBC_1	0.3056
p.G48A	DO463	BLCA	ICGC	PVTST	DEG_SPOP_SBC_1	0.3056
p.A41P	DO230334	COCA	ICGC	PVTST	DEG_SPOP_SBC_1	0.2778
p.A41P	DO229010	COCA	ICGC	PVTST	DEG_SPOP_SBC_1	0.2778
p.A41P	DO229013	COCA	ICGC	PVTST	DEG_SPOP_SBC_1	0.2778
p.A41P	DO229016	COCA	ICGC	PVTST	DEG_SPOP_SBC_1	0.2778
p.A41P	DO229003	COCA	ICGC	PVTST	DEG_SPOP_SBC_1	0.2778
p.A41P	DO229005	COCA	ICGC	PVTST	DEG_SPOP_SBC_1	0.2778
p.A41P	DO234285	ESAD	ICGC	PVTST	DEG_SPOP_SBC_1	0.2778
p.K39R	DO233941	GACA	ICGC	PVTST	DEG_SPOP_SBC_1	0.3333
p.I55N	DO231569	LINC	ICGC	PVTST	DEG_SPOP_SBC_1	0.1111
p.R45G	DO232846	NACA	ICGC	PVTST	DEG_SPOP_SBC_1	0.7568
p.V48M	DO233299	NACA	ICGC	PVTST	DEG_SPOP_SBC_1	0.3056
p.R41H	DO51407	PRAD	ICGC	PVTST	DEG_SPOP_SBC_1	0.2778
p.P33S	DO218847	SKCA	ICGC	PVTST	DEG_SPOP_SBC_1	0.0556
p.T53I	DO51276	SKCM	ICGC	PVTST	DEG_SPOP_SBC_1	0.1667
p.T53I	DO43755	UCEC	ICGC	PVTST	DEG_SPOP_SBC_1	0.1667
p.R41C	DO40828	UCEC	ICGC	PVTST	DEG_SPOP_SBC_1	0.2778
p.T40I	SIDM02021	Esophageal Carcinoma	GDSC	PVTST	DEG_SPOP_SBC_1	0.25
p.Q52L	ACH-000920	Leukemia	CCLE	PVTST	DEG_SPOP_SBC_1	0.1944
p.Q52L	CML-T1	haematopoietic_and_lymphoid_tissue	COSMIC	PVTST	DEG_SPOP_SBC_1	0.1944
p.G39R	RKO	large_intestine	COSMIC	PVTST	DEG_SPOP_SBC_1	0.3333
p.F55C	PE/CA-PJ15	upper_aerodigestive_tract	COSMIC	PVTST	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NCS4	Homeobox protein Nkx-2.6	DEG_SPOP_SBC_1	5:9	PVTST	SPOP	0.9836	More...
O75553	Disabled homolog 1	DEG_SPOP_SBC_1	504:508	PVTST	SPOP	0.9801	More...
O75554	WW domain-binding protein 4	DEG_SPOP_SBC_1	96:100	PVTST	SPOP	0.9878	More...
P22736	Nuclear receptor subfamily 4 group A member 1	DEG_SPOP_SBC_1	249:253	PVTST	SPOP	0.9805	More...
P49790	Nuclear pore complex protein Nup153	DEG_SPOP_SBC_1	1110:1114	PVTST	SPOP	0.9978	More...
P55197	Protein AF-10	DEG_SPOP_SBC_1	884:888	PVTST	SPOP	0.8239	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2221:2225	PVTST	SPOP	0.7357	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3327:3331	PVTST	SPOP	0.6584	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3625:3629	PVTST	SPOP	0.944	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	4058:4062	PVTST	SPOP	0.975	More...
Q13131	5'-AMP-activated protein kinase catalytic subunit alpha-1	DEG_SPOP_SBC_1	450:454	PVTST	SPOP	0.9471	More...
Q6NXT4	Zinc transporter 6	DEG_SPOP_SBC_1	372:376	PVTST	SPOP	0.9593	More...
Q6PL24	Protein TMED8	DEG_SPOP_SBC_1	225:229	PVTST	SPOP	0.9343	More...
Q6UN15	Pre-mRNA 3'-end-processing factor FIP1	DEG_SPOP_SBC_1	203:207	PVTST	SPOP	0.9115	More...
Q7Z7B0	Filamin-A-interacting protein 1	DEG_SPOP_SBC_1	799:803	PVTST	SPOP	0.9685	More...
Q8TAU0	Homeobox protein Nkx-2.3	DEG_SPOP_SBC_1	6:10	PVTST	SPOP	0.9861	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	12048:12052	PVTST	SPOP	0.6132	More...
Q99102	Mucin-4	DEG_SPOP_SBC_1	43:47	PVTST	SPOP	0.5365	More...
Q99102	Mucin-4	DEG_SPOP_SBC_1	1490:1494	PVTST	SPOP	0.9531	More...
Q9P2P6	StAR-related lipid transfer protein 9	DEG_SPOP_SBC_1	4244:4248	PVTST	SPOP	0.8399	More...
Q9UHY1	Nuclear receptor-binding protein	DEG_SPOP_SBC_1	33:37	PVTST	SPOP	0.6542	More...
Q9Y520	Protein PRRC2C	DEG_SPOP_SBC_1	2269:2273	PVTST	SPOP	0.9984	More...
Q5TID7	Coiled-coil domain-containing protein 181	DEG_SPOP_SBC_1	328:332	PVTST	SPOP	0.9574	More...
Q8IXQ8	PDZ domain-containing protein 9	DEG_SPOP_SBC_1	131:135	PVTST	SPOP	0.8501	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PVTST

Degron related mutations and impact score

Drug responses associated with MUC4 mutations

All proteins holding degron of PVTST