DegronMD - Q9P2P6(STARD9)

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GO - Molecular function (MF): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V3328F	TCGA-A2-A25A	BRCA	TCGA	PTPQFS	DEG_SCF_FBW7_1	3322:3327	Mutation rewiring degron network	0.3056
p.V3328F	DO3101	BRCA	ICGC	PTPQFS	DEG_SCF_FBW7_1	3322:3327	Mutation rewiring degron network	0.3056
p.M3409L	TCGA-A5-A0VQ	UCEC	TCGA	MPTPDFT	DEG_SCF_FBW7_1	3416:3422	Mutation rewiring degron network	0.1389
p.M3409L	DO42113	UCEC	ICGC	MPTPDFT	DEG_SCF_FBW7_1	3416:3422	Mutation rewiring degron network	0.1389
p.S3334Y	TCGA-B5-A0JY	UCEC	TCGA	PTPQFS	DEG_SCF_FBW7_1	3322:3327	Mutation rewiring degron network	0.1389
p.S3334Y	DO43041	UCEC	ICGC	PTPQFS	DEG_SCF_FBW7_1	3322:3327	Mutation rewiring degron network	0.1389
p.T321I	TCGA-EC-A24G	UCEC	TCGA	DSGILSS	DEG_SCF_TRCP1_1	311:317	Mutation rewiring degron network	0.2222
p.T321I	DO40996	UCEC	ICGC	DSGILSS	DEG_SCF_TRCP1_1	311:317	Mutation rewiring degron network	0.2222
p.A4238V	TCGA-EO-A22U	UCEC	TCGA	PVTST	DEG_SPOP_SBC_1	4244:4248	Mutation rewiring degron network	0.1667
p.A4238V	DO230326	COCA	ICGC	PVTST	DEG_SPOP_SBC_1	4244:4248	Mutation rewiring degron network	0.1667
p.A4238V	DO43755	UCEC	ICGC	PVTST	DEG_SPOP_SBC_1	4244:4248	Mutation rewiring degron network	0.1667
p.P318T	TCGA-EY-A547	UCEC	TCGA	DSGILSS	DEG_SCF_TRCP1_1	311:317	Mutation rewiring degron network	0.3056
p.P318T	DO48188	UCEC	ICGC	DSGILSS	DEG_SCF_TRCP1_1	311:317	Mutation rewiring degron network	0.3056
p.V306D	TCGA-FI-A2F4	UCEC	TCGA	DSGILSS	DEG_SCF_TRCP1_1	311:317	Mutation rewiring degron network	0.1944
p.V306D	DO43434	UCEC	ICGC	DSGILSS	DEG_SCF_TRCP1_1	311:317	Mutation rewiring degron network	0.1944
p.V1865L	DO8264	COAD	ICGC	PSTST	DEG_SPOP_SBC_1	1859:1863	Mutation rewiring degron network	0.2778
p.R598C	DO230326	COCA	ICGC	GRGSLEWLD	DEG_APCC_DBOX_1	597:605	Mutation altering degron motif	0.8301
p.S1849Y	DO222762	COCA	ICGC	PSTST	DEG_SPOP_SBC_1	1859:1863	Mutation rewiring degron network	0.0556
p.L4239H	DO50411	ESAD	ICGC	PVTST	DEG_SPOP_SBC_1	4244:4248	Mutation rewiring degron network	0.1944
p.G3330S	DO234182	ESAD	ICGC	PTPQFS	DEG_SCF_FBW7_1	3322:3327	Mutation rewiring degron network	0.25
p.L1744W	DO234461	ESAD	ICGC	PLSSS	DEG_SPOP_SBC_1	1734:1738	Mutation rewiring degron network	0.1667
p.L615M	DO228542	GACA	ICGC	GRGSLEWLD	DEG_APCC_DBOX_1	597:605	Mutation rewiring degron network	0.0556
p.P3410T	DO228946	LICA	ICGC	MPTPDFT	DEG_SCF_FBW7_1	3416:3422	Mutation rewiring degron network	0.1667
p.G309C	DO228952	LICA	ICGC	DSGILSS	DEG_SCF_TRCP1_1	311:317	Mutation rewiring degron network	0.2778
p.G599V	DO228986	LICA	ICGC	GRGSLEWLD	DEG_APCC_DBOX_1	597:605	Mutation altering degron motif	0.6421
p.V591F	DO229018	LICA	ICGC	GRGSLEWLD	DEG_APCC_DBOX_1	597:605	Mutation rewiring degron network	0.1667
p.V591F	DO229026	LICA	ICGC	GRGSLEWLD	DEG_APCC_DBOX_1	597:605	Mutation rewiring degron network	0.1667
p.A596S	DO229029	LICA	ICGC	GRGSLEWLD	DEG_APCC_DBOX_1	597:605	Mutation rewiring degron network	0.3056
p.E1724D	DO229025	LICA	ICGC	PLSSS	DEG_SPOP_SBC_1	1734:1738	Mutation rewiring degron network	0.0556
p.E1724D	DO229009	LICA	ICGC	PLSSS	DEG_SPOP_SBC_1	1734:1738	Mutation rewiring degron network	0.0556
p.G597V	DO229034	LICA	ICGC	GRGSLEWLD	DEG_APCC_DBOX_1	597:605	Mutation altering degron motif	0.6421
p.S322I	DO229045	LICA	ICGC	DSGILSS	DEG_SCF_TRCP1_1	311:317	Mutation blocking phosphorylation signal	0.6389
p.R614L	DO229006	LICA	ICGC	GRGSLEWLD	DEG_APCC_DBOX_1	597:605	Mutation rewiring degron network	0.0833
p.E1724V	DO44888	LIHC	ICGC	PLSSS	DEG_SPOP_SBC_1	1734:1738	Mutation rewiring degron network	0.0556
p.S3318F	DO23735	LUAD	ICGC	PTPQFS	DEG_SCF_FBW7_1	3322:3327	Mutation rewiring degron network	0.2222
p.P1734S	DO222638	MELA	ICGC	PLSSS	DEG_SPOP_SBC_1	1734:1738	Mutation altering degron motif	0.6752
p.G4236W	DO35442	PACA	ICGC	PVTST	DEG_SPOP_SBC_1	4244:4248	Mutation rewiring degron network	0.1111
p.V1872F	DO36556	READ	ICGC	PSTST	DEG_SPOP_SBC_1	1859:1863	Mutation rewiring degron network	0.0833
p.P318L	DO218912	SKCA	ICGC	DSGILSS	DEG_SCF_TRCP1_1	311:317	Mutation rewiring degron network	0.3056
p.D605G	DO229144	THCA	ICGC	GRGSLEWLD	DEG_APCC_DBOX_1	597:605	Mutation altering degron motif	0.6087
p.L1858I	SIDM02057	Colorectal Carcinoma	GDSC	PSTST	DEG_SPOP_SBC_1	1859:1863	Mutation rewiring degron network	0.3056
p.D605N	SIDM00007	Other Solid Cancers	GDSC	GRGSLEWLD	DEG_APCC_DBOX_1	597:605	Mutation altering degron motif	0.5821
p.D605N	ACH-001550	Skin Cancer	CCLE	GRGSLEWLD	DEG_APCC_DBOX_1	597:605	Mutation altering degron motif	0.5821
p.E1286D	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	FQPHCE	LIG_APCC_ABBA_1	1281:1286	Mutation altering degron motif	0.5647
p.E1286D	ACH-000945	Lung Cancer	CCLE	FQPHCE	LIG_APCC_ABBA_1	1281:1286	Mutation altering degron motif	0.5647
p.P1295L	SIDM00863	Burkitt's Lymphoma	GDSC	FQPHCE	LIG_APCC_ABBA_1	1281:1286	Mutation rewiring degron network	0.0833
p.P3408L	ACH-000209	Bile Duct Cancer	CCLE	MPTPDFT	DEG_SCF_FBW7_1	3416:3422	Mutation rewiring degron network	0.1111
p.V3328L	ACH-000582	Skin Cancer	CCLE	PTPQFS	DEG_SCF_FBW7_1	3322:3327	Mutation rewiring degron network	0.3056
p.R3333H	ACH-001142	Non-Cancerous	CCLE	PTPQFS	DEG_SCF_FBW7_1	3322:3327	Mutation rewiring degron network	0.1667
p.D609V	ACH-001864	Bile Duct Cancer	CCLE	GRGSLEWLD	DEG_APCC_DBOX_1	597:605	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

STARD9

UniProt ID: Q9P2P6

Entrez ID: 57519

Protein name: StAR-related lipid transfer protein 9 (START domain-containing protein 9) (StARD9)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for STARD9 in