DegronMD

Uniprot ID: Q9P2P6

Source protein: StAR-related lipid transfer protein 9

Source gene: STARD9

Class: DEG_APCC_DBOX_1

Location: 597:605

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8981

ASA_SCORE: 84.8444

COIL: 0.6628

CONS_SCORE: 0.5424

DSS_SCORE: 0.2383

HELIX: 0.2938

FCONS_SCORE: 1.2976

RIG_SCORE: 0.7697

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R598C	DO230326	COCA	ICGC	GRGSLEWLD	DEG_APCC_DBOX_1	0.8301
p.G599V	DO228986	LICA	ICGC	GRGSLEWLD	DEG_APCC_DBOX_1	0.6421
p.G597V	DO229034	LICA	ICGC	GRGSLEWLD	DEG_APCC_DBOX_1	0.6421
p.D605G	DO229144	THCA	ICGC	GRGSLEWLD	DEG_APCC_DBOX_1	0.6087
p.D605N	SIDM00007	Other Solid Cancers	GDSC	GRGSLEWLD	DEG_APCC_DBOX_1	0.5821
p.D605N	ACH-001550	Skin Cancer	CCLE	GRGSLEWLD	DEG_APCC_DBOX_1	0.5821
p.A596S	DO229029	LICA	ICGC	GRGSLEWLD	DEG_APCC_DBOX_1	0.3056
p.D609V	ACH-001864	Bile Duct Cancer	CCLE	GRGSLEWLD	DEG_APCC_DBOX_1	0.2222
p.V591F	DO229018	LICA	ICGC	GRGSLEWLD	DEG_APCC_DBOX_1	0.1667
p.V591F	DO229026	LICA	ICGC	GRGSLEWLD	DEG_APCC_DBOX_1	0.1667
p.R614L	DO229006	LICA	ICGC	GRGSLEWLD	DEG_APCC_DBOX_1	0.0833
p.L615M	DO228542	GACA	ICGC	GRGSLEWLD	DEG_APCC_DBOX_1	0.0556

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P2P6	StAR-related lipid transfer protein 9	DEG_APCC_DBOX_1	597:605	GRGSLEWLD	APC,CDC20,FZR1	0.8981	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons