DegronMD - Q9Y520(PRRC2C)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R53H	TCGA-44-7667	LUAD	TCGA	ARHGLQSLG	DEG_APCC_DBOX_1	38:46	Mutation rewiring degron network	0.1389
p.R53H	TCGA-A8-A0A9	BRCA	TCGA	ARHGLQSLG	DEG_APCC_DBOX_1	38:46	Mutation rewiring degron network	0.1389
p.R53H	TCGA-EO-A22R	UCEC	TCGA	ARHGLQSLG	DEG_APCC_DBOX_1	38:46	Mutation rewiring degron network	0.1389
p.T2312A	TCGA-78-7539	LUAD	TCGA	VTPTAS	DEG_SCF_FBW7_1	2309:2314	Mutation altering degron motif	0.6028
p.T2312A	TCGA-78-7539	LUAD	TCGA	IPVASVTPT	DEG_SIAH_1	2304:2312	Mutation altering degron motif	0.6028
p.R52G	TCGA-A4-8630	KIRP	TCGA	ARHGLQSLG	DEG_APCC_DBOX_1	38:46	Mutation rewiring degron network	0.1667
p.P2305L	TCGA-A5-A0G2	UCEC	TCGA	IPVASVTPT	DEG_SIAH_1	2304:2312	Mutation altering degron motif	0.7582
p.L45I	TCGA-AP-A056	UCEC	TCGA	ARHGLQSLG	DEG_APCC_DBOX_1	38:46	Mutation altering degron motif	0.6063
p.V48I	TCGA-AX-A0J0	UCEC	TCGA	ARHGLQSLG	DEG_APCC_DBOX_1	38:46	Mutation rewiring degron network	0.2778
p.R53C	TCGA-AX-A0J1	UCEC	TCGA	ARHGLQSLG	DEG_APCC_DBOX_1	38:46	Mutation rewiring degron network	0.1389
p.R53C	SIDM01016	T-Lymphoblastic Leukemia	GDSC	ARHGLQSLG	DEG_APCC_DBOX_1	38:46	Mutation rewiring degron network	0.1389
p.R53C	ACH-000995	Leukemia	CCLE	ARHGLQSLG	DEG_APCC_DBOX_1	38:46	Mutation rewiring degron network	0.1389
p.R53C	Jurkat	haematopoietic and lymphoid tissue	COSMIC	ARHGLQSLG	DEG_APCC_DBOX_1	38:46	Mutation rewiring degron network	0.1389
p.P1771L	TCGA-AX-A2HA	UCEC	TCGA	PASTS	DEG_SPOP_SBC_1	1763:1767	Mutation rewiring degron network	0.2222
p.P1771L	TCGA-AX-A2HA	UCEC	TCGA	PASTS	DEG_SPOP_SBC_1	1778:1782	Mutation rewiring degron network	0.1389
p.P1771L	DO229177	LMS	ICGC	PASTS	DEG_SPOP_SBC_1	1763:1767	Mutation rewiring degron network	0.2222
p.P1771L	DO229177	LMS	ICGC	PASTS	DEG_SPOP_SBC_1	1778:1782	Mutation rewiring degron network	0.1389
p.R39Q	TCGA-B5-A0JY	UCEC	TCGA	ARHGLQSLG	DEG_APCC_DBOX_1	38:46	Mutation altering degron motif	0.7329
p.S2295L	TCGA-B5-A0JY	UCEC	TCGA	IPVASVTPT	DEG_SIAH_1	2304:2312	Mutation rewiring degron network	0.0833
p.S2295L	TCGA-EE-A2M5	SKCM	TCGA	IPVASVTPT	DEG_SIAH_1	2304:2312	Mutation rewiring degron network	0.0833
p.S2295L	TCGA-EE-A2MC	SKCM	TCGA	IPVASVTPT	DEG_SIAH_1	2304:2312	Mutation rewiring degron network	0.0833
p.T2681I	TCGA-BK-A13B	UCEC	TCGA	ATSTS	DEG_SPOP_SBC_1	2690:2694	Mutation blocking phosphorylation signal	0.5278
p.S2268A	TCGA-BS-A0UV	UCEC	TCGA	PVTST	DEG_SPOP_SBC_1	2269:2273	Mutation rewiring degron network	0.3056
p.R52W	TCGA-C5-A902	CESC	TCGA	ARHGLQSLG	DEG_APCC_DBOX_1	38:46	Mutation rewiring degron network	0.1667
p.G2319C	TCGA-D3-A3CE	SKCM	TCGA	VTPTAS	DEG_SCF_FBW7_1	2309:2314	Mutation rewiring degron network	0.1944
p.G2319C	TCGA-D3-A3CE	SKCM	TCGA	IPVASVTPT	DEG_SIAH_1	2304:2312	Mutation rewiring degron network	0.1389
p.G2319C	TCGA-FS-A1ZN	SKCM	TCGA	VTPTAS	DEG_SCF_FBW7_1	2309:2314	Mutation rewiring degron network	0.1944
p.G2319C	TCGA-FS-A1ZN	SKCM	TCGA	IPVASVTPT	DEG_SIAH_1	2304:2312	Mutation rewiring degron network	0.1389
p.N2696H	TCGA-DX-A23Y	SARC	TCGA	ATSTS	DEG_SPOP_SBC_1	2690:2694	Mutation rewiring degron network	0.2778
p.T1823I	TCGA-E9-A1RH	BRCA	TCGA	PASTS	DEG_SPOP_SBC_1	1820:1824	Mutation altering degron motif	0.7078
p.P2269S	TCGA-EE-A29D	SKCM	TCGA	PVTST	DEG_SPOP_SBC_1	2269:2273	Mutation altering degron motif	0.6752
p.P345H	TCGA-EE-A29S	SKCM	TCGA	PKENN	DEG_APCC_KENBOX_2	345:349	Mutation altering degron motif	0.6583
p.P2276T	TCGA-EE-A3AC	SKCM	TCGA	PVTST	DEG_SPOP_SBC_1	2269:2273	Mutation rewiring degron network	0.25
p.S1751L	TCGA-F5-6814	READ	TCGA	PPSTS	DEG_SPOP_SBC_1	1755:1759	Mutation rewiring degron network	0.2222
p.A1817T	TCGA-FI-A2D0	UCEC	TCGA	PASTS	DEG_SPOP_SBC_1	1820:1824	Mutation rewiring degron network	0.25
p.S1812L	TCGA-IR-A3LL	CESC	TCGA	PASTS	DEG_SPOP_SBC_1	1820:1824	Mutation rewiring degron network	0.1111
p.S1826L	DO227836	BRCA	ICGC	PASTS	DEG_SPOP_SBC_1	1820:1824	Mutation rewiring degron network	0.2778
p.T1825I	DO1279	BRCA	ICGC	PASTS	DEG_SPOP_SBC_1	1820:1824	Mutation rewiring degron network	0.3056
p.R55H	DO2473	BRCA	ICGC	ARHGLQSLG	DEG_APCC_DBOX_1	38:46	Mutation rewiring degron network	0.0833
p.R55H	DO23830	LUAD	ICGC	ARHGLQSLG	DEG_APCC_DBOX_1	38:46	Mutation rewiring degron network	0.0833
p.R55H	DO42713	UCEC	ICGC	ARHGLQSLG	DEG_APCC_DBOX_1	38:46	Mutation rewiring degron network	0.0833
p.R54W	DO49916	CESC	ICGC	ARHGLQSLG	DEG_APCC_DBOX_1	38:46	Mutation rewiring degron network	0.1111
p.S1814L	DO44362	CESC	ICGC	PASTS	DEG_SPOP_SBC_1	1820:1824	Mutation rewiring degron network	0.1667
p.P1758A	DO9042	COAD	ICGC	PPSTS	DEG_SPOP_SBC_1	1755:1759	Mutation altering degron motif	0.7503
p.T2683I	DO227745	COCA	ICGC	ATSTS	DEG_SPOP_SBC_1	2690:2694	Mutation rewiring degron network	0.1389
p.T2683I	DO40825	UCEC	ICGC	ATSTS	DEG_SPOP_SBC_1	2690:2694	Mutation rewiring degron network	0.1389
p.S2297L	DO233270	GACA	ICGC	IPVASVTPT	DEG_SIAH_1	2304:2312	Mutation rewiring degron network	0.1389
p.S2297L	DO222423	MELA	ICGC	IPVASVTPT	DEG_SIAH_1	2304:2312	Mutation rewiring degron network	0.1389
p.S2297L	DO222843	MELA	ICGC	IPVASVTPT	DEG_SIAH_1	2304:2312	Mutation rewiring degron network	0.1389
p.S2297L	DO37559	SKCM	ICGC	IPVASVTPT	DEG_SIAH_1	2304:2312	Mutation rewiring degron network	0.1389
p.S2297L	DO37425	SKCM	ICGC	IPVASVTPT	DEG_SIAH_1	2304:2312	Mutation rewiring degron network	0.1389
p.S2297L	DO43041	UCEC	ICGC	IPVASVTPT	DEG_SIAH_1	2304:2312	Mutation rewiring degron network	0.1389
p.P2277L	DO233698	GACA	ICGC	PVTST	DEG_SPOP_SBC_1	2269:2273	Mutation rewiring degron network	0.2222
p.A1829V	DO233782	GACA	ICGC	PASTS	DEG_SPOP_SBC_1	1820:1824	Mutation rewiring degron network	0.1944
p.A1815V	DO233804	GACA	ICGC	PASTS	DEG_SPOP_SBC_1	1820:1824	Mutation rewiring degron network	0.1944
p.R54G	DO44489	KIRP	ICGC	ARHGLQSLG	DEG_APCC_DBOX_1	38:46	Mutation rewiring degron network	0.1111
p.S2696I	DO228976	LICA	ICGC	ATSTS	DEG_SPOP_SBC_1	2690:2694	Mutation rewiring degron network	0.2778
p.S344I	DO229025	LICA	ICGC	PKENN	DEG_APCC_KENBOX_2	345:349	Mutation blocking phosphorylation signal	0.75
p.G696C	DO229035	LICA	ICGC	PSSST	DEG_SPOP_SBC_1	704:708	Mutation rewiring degron network	0.1111
p.A2309S	DO229035	LICA	ICGC	VTPTAS	DEG_SCF_FBW7_1	2309:2314	Mutation altering degron motif	0.7588
p.A2309S	DO229035	LICA	ICGC	IPVASVTPT	DEG_SIAH_1	2304:2312	Mutation altering degron motif	0.7588
p.M2704I	DO229035	LICA	ICGC	ATSTS	DEG_SPOP_SBC_1	2690:2694	Mutation blocking phosphorylation signal	0.5
p.R41L	DO229006	LICA	ICGC	ARHGLQSLG	DEG_APCC_DBOX_1	38:46	Mutation altering degron motif	0.8428
p.V50F	DO229008	LICA	ICGC	ARHGLQSLG	DEG_APCC_DBOX_1	38:46	Mutation rewiring degron network	0.2222
p.A2320T	DO48719	LIRI	ICGC	VTPTAS	DEG_SCF_FBW7_1	2309:2314	Mutation rewiring degron network	0.1667
p.A2320T	DO48719	LIRI	ICGC	IPVASVTPT	DEG_SIAH_1	2304:2312	Mutation rewiring degron network	0.1111
p.T2314A	DO26210	LUAD	ICGC	VTPTAS	DEG_SCF_FBW7_1	2309:2314	Mutation altering degron motif	0.7139
p.A1789T	DO230929	LUSC	ICGC	PASTS	DEG_SPOP_SBC_1	1778:1782	Mutation rewiring degron network	0.1389
p.A1789T	DO224572	LUSC	ICGC	PASTS	DEG_SPOP_SBC_1	1778:1782	Mutation rewiring degron network	0.1389
p.R2266S	DO231016	LUSC	ICGC	PVTST	DEG_SPOP_SBC_1	2269:2273	Mutation substituting flanking lysine	0.3611
p.S1769A	DO46390	OV	ICGC	PPSTS	DEG_SPOP_SBC_1	1755:1759	Mutation rewiring degron network	0.0556
p.S1769A	DO46390	OV	ICGC	PASTS	DEG_SPOP_SBC_1	1763:1767	Mutation rewiring degron network	0.2778
p.S1769A	DO46390	OV	ICGC	PASTS	DEG_SPOP_SBC_1	1778:1782	Mutation rewiring degron network	0.0833
p.P1755L	DO49128	PACA	ICGC	PPSTS	DEG_SPOP_SBC_1	1755:1759	Mutation altering degron motif	0.7582
p.P1822A	DO51474	PACA	ICGC	PASTS	DEG_SPOP_SBC_1	1820:1824	Mutation altering degron motif	0.7503
p.S2687Y	DO232761	PBCA	ICGC	ATSTS	DEG_SPOP_SBC_1	2690:2694	Mutation rewiring degron network	0.25
p.A1785V	DO233478	PRAD	ICGC	PASTS	DEG_SPOP_SBC_1	1778:1782	Mutation rewiring degron network	0.25
p.S1753L	DO36556	READ	ICGC	PPSTS	DEG_SPOP_SBC_1	1755:1759	Mutation rewiring degron network	0.2778
p.S1753L	DO36556	READ	ICGC	PASTS	DEG_SPOP_SBC_1	1763:1767	Mutation rewiring degron network	0.0556
p.N2698H	DO219958	SARC	ICGC	ATSTS	DEG_SPOP_SBC_1	2690:2694	Mutation rewiring degron network	0.2222
p.P2278T	DO37631	SKCM	ICGC	PVTST	DEG_SPOP_SBC_1	2269:2273	Mutation rewiring degron network	0.1944
p.G2321C	DO37405	SKCM	ICGC	VTPTAS	DEG_SCF_FBW7_1	2309:2314	Mutation blocking phosphorylation signal	0.5833
p.G2321C	DO37405	SKCM	ICGC	IPVASVTPT	DEG_SIAH_1	2304:2312	Mutation blocking phosphorylation signal	0.5278
p.G2321C	DO38165	SKCM	ICGC	VTPTAS	DEG_SCF_FBW7_1	2309:2314	Mutation blocking phosphorylation signal	0.5833
p.G2321C	DO38165	SKCM	ICGC	IPVASVTPT	DEG_SIAH_1	2304:2312	Mutation blocking phosphorylation signal	0.5278
p.P347H	DO37936	SKCM	ICGC	PKENN	DEG_APCC_KENBOX_2	345:349	Mutation altering degron motif	0.7694
p.P2271S	DO38123	SKCM	ICGC	PVTST	DEG_SPOP_SBC_1	2269:2273	Mutation altering degron motif	0.6752
p.R41Q	DO43041	UCEC	ICGC	ARHGLQSLG	DEG_APCC_DBOX_1	38:46	Mutation altering degron motif	0.7329
p.P2307L	DO41235	UCEC	ICGC	IPVASVTPT	DEG_SIAH_1	2304:2312	Mutation altering degron motif	0.7582
p.A1819T	DO43891	UCEC	ICGC	PASTS	DEG_SPOP_SBC_1	1820:1824	Mutation rewiring degron network	0.3056
p.P1773L	DO42504	UCEC	ICGC	PASTS	DEG_SPOP_SBC_1	1763:1767	Mutation rewiring degron network	0.1667
p.P1773L	DO42504	UCEC	ICGC	PASTS	DEG_SPOP_SBC_1	1778:1782	Mutation rewiring degron network	0.1944
p.R55C	DO41199	UCEC	ICGC	ARHGLQSLG	DEG_APCC_DBOX_1	38:46	Mutation rewiring degron network	0.0833
p.R55C	Jurkat	haematopoietic and lymphoid tissue	COSMIC	ARHGLQSLG	DEG_APCC_DBOX_1	38:46	Mutation rewiring degron network	0.0833
p.V50I	DO41133	UCEC	ICGC	ARHGLQSLG	DEG_APCC_DBOX_1	38:46	Mutation rewiring degron network	0.2222
p.S2270A	DO42793	UCEC	ICGC	PVTST	DEG_SPOP_SBC_1	2269:2273	Mutation altering degron motif	0.7588
p.L47I	DO43971	UCEC	ICGC	ARHGLQSLG	DEG_APCC_DBOX_1	38:46	Mutation blocking ubiquitination signal	0.75
p.T2273I	SIDM00144	Non-Small Cell Lung Carcinoma	GDSC	PVTST	DEG_SPOP_SBC_1	2269:2273	Mutation altering degron motif	0.7078
p.T2273I	ACH-000463	Lung Cancer	CCLE	PVTST	DEG_SPOP_SBC_1	2269:2273	Mutation altering degron motif	0.7078
p.T2273I	NCI-H460	lung	COSMIC	PVTST	DEG_SPOP_SBC_1	2269:2273	Mutation altering degron motif	0.7078
p.P2275S	SIDM00444	Esophageal Carcinoma	GDSC	PVTST	DEG_SPOP_SBC_1	2269:2273	Mutation rewiring degron network	0.2778
p.P2275S	ACH-001368	Esophageal Cancer	CCLE	PVTST	DEG_SPOP_SBC_1	2269:2273	Mutation rewiring degron network	0.2778
p.P2275S	OACM5-1	oesophagus	COSMIC	PVTST	DEG_SPOP_SBC_1	2269:2273	Mutation rewiring degron network	0.2778
p.T1766A	SIDM00670	Pancreatic Carcinoma	GDSC	PASTS	DEG_SPOP_SBC_1	1763:1767	Mutation altering degron motif	0.7139
p.T1766A	ACH-000270	Pancreatic Cancer	CCLE	PASTS	DEG_SPOP_SBC_1	1763:1767	Mutation altering degron motif	0.7139
p.T1766A	ACH-000912	Lung Cancer	CCLE	PASTS	DEG_SPOP_SBC_1	1763:1767	Mutation altering degron motif	0.7139
p.T1766A	ACH-001098	Pancreatic Cancer	CCLE	PASTS	DEG_SPOP_SBC_1	1763:1767	Mutation altering degron motif	0.7139
p.T1766A	HPAC	pancreas	COSMIC	PASTS	DEG_SPOP_SBC_1	1763:1767	Mutation altering degron motif	0.7139
p.E32Q	SIDM00133	Non-Small Cell Lung Carcinoma	GDSC	ARHGLQSLG	DEG_APCC_DBOX_1	38:46	Mutation rewiring degron network	0.1667
p.E32Q	ACH-000861	Lung Cancer	CCLE	ARHGLQSLG	DEG_APCC_DBOX_1	38:46	Mutation rewiring degron network	0.1667
p.E32Q	HOP-62	lung	COSMIC	ARHGLQSLG	DEG_APCC_DBOX_1	38:46	Mutation rewiring degron network	0.1667
p.N343K	SIDM00379	Glioma	GDSC	PKENN	DEG_APCC_KENBOX_2	345:349	Mutation rewiring degron network	0.2778
p.S2260Y	SIDM01611	Endometrial Carcinoma	GDSC	PVTST	DEG_SPOP_SBC_1	2269:2273	Mutation blocking phosphorylation signal	0.5278
p.S2260Y	SIDM01588	Endometrial Carcinoma	GDSC	PVTST	DEG_SPOP_SBC_1	2269:2273	Mutation blocking phosphorylation signal	0.5278
p.S2260Y	ACH-000993	Endometrial/Uterine Cancer	CCLE	PVTST	DEG_SPOP_SBC_1	2269:2273	Mutation blocking phosphorylation signal	0.5278
p.S2260Y	ACH-000996	Endometrial/Uterine Cancer	CCLE	PVTST	DEG_SPOP_SBC_1	2269:2273	Mutation blocking phosphorylation signal	0.5278
p.S1818L	ACH-000999	Colon/Colorectal Cancer	CCLE	PASTS	DEG_SPOP_SBC_1	1820:1824	Mutation rewiring degron network	0.2778
p.T2275I	NCI-H460	lung	COSMIC	PVTST	DEG_SPOP_SBC_1	2269:2273	Mutation rewiring degron network	0.2778
p.L42F	HSC-3	upper aerodigestive tract	COSMIC	ARHGLQSLG	DEG_APCC_DBOX_1	38:46	Mutation altering degron motif	0.6981
p.E47Q	CAL-148	breast	COSMIC	ARHGLQSLG	DEG_APCC_DBOX_1	38:46	Mutation blocking ubiquitination signal	0.75
p.T1768A	HPAC	pancreas	COSMIC	PPSTS	DEG_SPOP_SBC_1	1755:1759	Mutation rewiring degron network	0.0833
p.T1768A	HPAC	pancreas	COSMIC	PASTS	DEG_SPOP_SBC_1	1763:1767	Mutation rewiring degron network	0.3056
p.T1768A	HPAC	pancreas	COSMIC	PASTS	DEG_SPOP_SBC_1	1778:1782	Mutation rewiring degron network	0.0556
p.R50H	DG-75	haematopoietic and lymphoid tissue	COSMIC	ARHGLQSLG	DEG_APCC_DBOX_1	38:46	Mutation rewiring degron network	0.2222
p.L44F	HSC-3	upper aerodigestive tract	COSMIC	ARHGLQSLG	DEG_APCC_DBOX_1	38:46	Mutation altering degron motif	0.6981
p.P2277S	OACM5-1	oesophagus	COSMIC	PVTST	DEG_SPOP_SBC_1	2269:2273	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PRRC2C

UniProt ID: Q9Y520

Entrez ID: 23215

Protein name: Protein PRRC2C (BAT2 domain-containing protein 1) (HBV X-transactivated gene 2 protein) (HBV XAg-transactivated protein 2) (HLA-B-associated transcript 2-like 2) (Proline-rich and coiled-coil-containing protein 2C)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PRRC2C in