DegronMD

Uniprot ID: Q9Y520

Source protein: Protein PRRC2C

Source gene: PRRC2C

Class: DEG_SIAH_1

Location: 2304:2312

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9944

ASA_SCORE: 87.1

COIL: 0.9537

CONS_SCORE: 0.5319

DSS_SCORE: 0.4048

HELIX: 0.0148

FCONS_SCORE: 1.0417

RIG_SCORE: 0.7288

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T2312A	TCGA-78-7539	LUAD	TCGA	IPVASVTPT	DEG_SIAH_1	0.6028
p.P2305L	TCGA-A5-A0G2	UCEC	TCGA	IPVASVTPT	DEG_SIAH_1	0.7582
p.S2295L	TCGA-B5-A0JY	UCEC	TCGA	IPVASVTPT	DEG_SIAH_1	0.0833
p.S2295L	TCGA-EE-A2M5	SKCM	TCGA	IPVASVTPT	DEG_SIAH_1	0.0833
p.S2295L	TCGA-EE-A2MC	SKCM	TCGA	IPVASVTPT	DEG_SIAH_1	0.0833
p.G2319C	TCGA-D3-A3CE	SKCM	TCGA	IPVASVTPT	DEG_SIAH_1	0.1389
p.G2319C	TCGA-FS-A1ZN	SKCM	TCGA	IPVASVTPT	DEG_SIAH_1	0.1389
p.S2297L	DO233270	GACA	ICGC	IPVASVTPT	DEG_SIAH_1	0.1389
p.S2297L	DO222423	MELA	ICGC	IPVASVTPT	DEG_SIAH_1	0.1389
p.S2297L	DO222843	MELA	ICGC	IPVASVTPT	DEG_SIAH_1	0.1389
p.S2297L	DO37559	SKCM	ICGC	IPVASVTPT	DEG_SIAH_1	0.1389
p.S2297L	DO37425	SKCM	ICGC	IPVASVTPT	DEG_SIAH_1	0.1389
p.S2297L	DO43041	UCEC	ICGC	IPVASVTPT	DEG_SIAH_1	0.1389
p.A2309S	DO229035	LICA	ICGC	IPVASVTPT	DEG_SIAH_1	0.7588
p.A2320T	DO48719	LIRI	ICGC	IPVASVTPT	DEG_SIAH_1	0.1111
p.G2321C	DO37405	SKCM	ICGC	IPVASVTPT	DEG_SIAH_1	0.5278
p.G2321C	DO38165	SKCM	ICGC	IPVASVTPT	DEG_SIAH_1	0.5278
p.P2307L	DO41235	UCEC	ICGC	IPVASVTPT	DEG_SIAH_1	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y520	Protein PRRC2C	DEG_SIAH_1	2304:2312	IPVASVTPT	SIAH1,SIAH2,SIAH3	0.9944	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons