DegronMD

Uniprot ID: Q9Y520

Source protein: Protein PRRC2C

Source gene: PRRC2C

Class: DEG_APCC_KENBOX_2

Location: 345:349

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6229

ASA_SCORE: 110.42

COIL: 0.8802

CONS_SCORE: 0.3097

DSS_SCORE: 0.8629

HELIX: 0.0948

FCONS_SCORE: 0.6033

RIG_SCORE: 0.5288

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P345H	TCGA-EE-A29S	SKCM	TCGA	PKENN	DEG_APCC_KENBOX_2	0.6583
p.S344I	DO229025	LICA	ICGC	PKENN	DEG_APCC_KENBOX_2	0.75
p.P347H	DO37936	SKCM	ICGC	PKENN	DEG_APCC_KENBOX_2	0.7694
p.N343K	SIDM00379	Glioma	GDSC	PKENN	DEG_APCC_KENBOX_2	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons