DegronMD

Uniprot ID: Q86XU0

Source protein: Zinc finger protein 677

Source gene: ZNF677

Class: DEG_APCC_KENBOX_2

Location: 69:73

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6615

ASA_SCORE: 109.56

COIL: 0.8128

CONS_SCORE: 0.3266

DSS_SCORE: 0.3653

HELIX: 0.0886

FCONS_SCORE: 1.3181

RIG_SCORE: 0.6657

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S64I	TCGA-55-8507	LUAD	TCGA	PKENN	DEG_APCC_KENBOX_2	0.1944
p.S64I	DO45412	LUAD	ICGC	PKENN	DEG_APCC_KENBOX_2	0.1944
p.N72H	TCGA-AA-3977	COAD	TCGA	PKENN	DEG_APCC_KENBOX_2	0.7423
p.N72H	DO8730	COAD	ICGC	PKENN	DEG_APCC_KENBOX_2	0.7423
p.Y78H	TCGA-AG-A002	READ	TCGA	PKENN	DEG_APCC_KENBOX_2	0.1944
p.E75D	TCGA-CD-5801	STAD	TCGA	PKENN	DEG_APCC_KENBOX_2	0.2778
p.E75D	DO38563	STAD	ICGC	PKENN	DEG_APCC_KENBOX_2	0.2778
p.K65T	TCGA-CG-4441	STAD	TCGA	PKENN	DEG_APCC_KENBOX_2	0.3333
p.K65T	DO38250	STAD	ICGC	PKENN	DEG_APCC_KENBOX_2	0.3333
p.E71K	TCGA-EE-A2GB	SKCM	TCGA	PKENN	DEG_APCC_KENBOX_2	0.7022
p.E71K	DO222683	MELA	ICGC	PKENN	DEG_APCC_KENBOX_2	0.7022
p.E71K	DO37417	SKCM	ICGC	PKENN	DEG_APCC_KENBOX_2	0.7022
p.K74E	TCGA-SG-A849	SARC	TCGA	PKENN	DEG_APCC_KENBOX_2	0.3056
p.K74E	DO887	BOCA	ICGC	PKENN	DEG_APCC_KENBOX_2	0.3056
p.K74E	DO220270	SARC	ICGC	PKENN	DEG_APCC_KENBOX_2	0.3056
p.L80H	DO231986	LICA	ICGC	PKENN	DEG_APCC_KENBOX_2	0.1389
p.P66L	DO44864	LICA	ICGC	PKENN	DEG_APCC_KENBOX_2	0.25
p.V70F	DO50776	LIRI	ICGC	PKENN	DEG_APCC_KENBOX_2	0.7068
p.E63K	DO222420	MELA	ICGC	PKENN	DEG_APCC_KENBOX_2	0.1667
p.V63L	DO51486	PACA	ICGC	PKENN	DEG_APCC_KENBOX_2	0.1667
p.L62F	DO51486	PACA	ICGC	PKENN	DEG_APCC_KENBOX_2	0.1389
p.S77Y	DO36556	READ	ICGC	PKENN	DEG_APCC_KENBOX_2	0.2222
p.S67F	DO219873	SKCA	ICGC	PKENN	DEG_APCC_KENBOX_2	0.2778
p.S67F	DO37627	SKCM	ICGC	PKENN	DEG_APCC_KENBOX_2	0.2778
p.K70N	DO229213	THCA	ICGC	PKENN	DEG_APCC_KENBOX_2	0.6918
p.H79R	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	PKENN	DEG_APCC_KENBOX_2	0.1667
p.H79R	SIDM00454	Rhabdomyosarcoma	GDSC	PKENN	DEG_APCC_KENBOX_2	0.1667
p.H79R	SIDM00633	Breast Carcinoma	GDSC	PKENN	DEG_APCC_KENBOX_2	0.1667
p.H79R	SIDM00844	Burkitt's Lymphoma	GDSC	PKENN	DEG_APCC_KENBOX_2	0.1667
p.H79R	SIDM00628	Breast Carcinoma	GDSC	PKENN	DEG_APCC_KENBOX_2	0.1667
p.S59P	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	PKENN	DEG_APCC_KENBOX_2	0.0556
p.S59P	NCI-H1155	lung	COSMIC	PKENN	DEG_APCC_KENBOX_2	0.0556
p.E71D	SIDM01611	Endometrial Carcinoma	GDSC	PKENN	DEG_APCC_KENBOX_2	0.6758
p.E71D	ACH-000996	Endometrial/Uterine Cancer	CCLE	PKENN	DEG_APCC_KENBOX_2	0.6758
p.H79Q	ACH-000929	Lung Cancer	CCLE	PKENN	DEG_APCC_KENBOX_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y520	Protein PRRC2C	DEG_APCC_KENBOX_2	345:349	PKENN	APC,CDC20,FZR1	0.6229	More...
Q86XU0	Zinc finger protein 677	DEG_APCC_KENBOX_2	69:73	PKENN	APC,CDC20,FZR1	0.6615	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PKENN

Degron related mutations and impact score

Drug responses associated with ZNF677 mutations

All proteins holding degron of PKENN