DegronMD

Uniprot ID: Q9Y520

Source protein: Protein PRRC2C

Source gene: PRRC2C

Class: DEG_APCC_DBOX_1

Location: 38:46

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9747

ASA_SCORE: 83.6111

COIL: 0.8404

CONS_SCORE: 0.6733

DSS_SCORE: 0.5525

HELIX: 0.1097

FCONS_SCORE: 1.0382

RIG_SCORE: 0.7168

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R53H	TCGA-44-7667	LUAD	TCGA	ARHGLQSLG	DEG_APCC_DBOX_1	0.1389
p.R53H	TCGA-A8-A0A9	BRCA	TCGA	ARHGLQSLG	DEG_APCC_DBOX_1	0.1389
p.R53H	TCGA-EO-A22R	UCEC	TCGA	ARHGLQSLG	DEG_APCC_DBOX_1	0.1389
p.R52G	TCGA-A4-8630	KIRP	TCGA	ARHGLQSLG	DEG_APCC_DBOX_1	0.1667
p.L45I	TCGA-AP-A056	UCEC	TCGA	ARHGLQSLG	DEG_APCC_DBOX_1	0.6063
p.V48I	TCGA-AX-A0J0	UCEC	TCGA	ARHGLQSLG	DEG_APCC_DBOX_1	0.2778
p.R53C	TCGA-AX-A0J1	UCEC	TCGA	ARHGLQSLG	DEG_APCC_DBOX_1	0.1389
p.R53C	SIDM01016	T-Lymphoblastic Leukemia	GDSC	ARHGLQSLG	DEG_APCC_DBOX_1	0.1389
p.R53C	ACH-000995	Leukemia	CCLE	ARHGLQSLG	DEG_APCC_DBOX_1	0.1389
p.R53C	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	ARHGLQSLG	DEG_APCC_DBOX_1	0.1389
p.R39Q	TCGA-B5-A0JY	UCEC	TCGA	ARHGLQSLG	DEG_APCC_DBOX_1	0.7329
p.R52W	TCGA-C5-A902	CESC	TCGA	ARHGLQSLG	DEG_APCC_DBOX_1	0.1667
p.R55H	DO2473	BRCA	ICGC	ARHGLQSLG	DEG_APCC_DBOX_1	0.0833
p.R55H	DO23830	LUAD	ICGC	ARHGLQSLG	DEG_APCC_DBOX_1	0.0833
p.R55H	DO42713	UCEC	ICGC	ARHGLQSLG	DEG_APCC_DBOX_1	0.0833
p.R54W	DO49916	CESC	ICGC	ARHGLQSLG	DEG_APCC_DBOX_1	0.1111
p.R54G	DO44489	KIRP	ICGC	ARHGLQSLG	DEG_APCC_DBOX_1	0.1111
p.R41L	DO229006	LICA	ICGC	ARHGLQSLG	DEG_APCC_DBOX_1	0.8428
p.V50F	DO229008	LICA	ICGC	ARHGLQSLG	DEG_APCC_DBOX_1	0.2222
p.R41Q	DO43041	UCEC	ICGC	ARHGLQSLG	DEG_APCC_DBOX_1	0.7329
p.R55C	DO41199	UCEC	ICGC	ARHGLQSLG	DEG_APCC_DBOX_1	0.0833
p.R55C	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	ARHGLQSLG	DEG_APCC_DBOX_1	0.0833
p.V50I	DO41133	UCEC	ICGC	ARHGLQSLG	DEG_APCC_DBOX_1	0.2222
p.L47I	DO43971	UCEC	ICGC	ARHGLQSLG	DEG_APCC_DBOX_1	0.75
p.E32Q	SIDM00133	Non-Small Cell Lung Carcinoma	GDSC	ARHGLQSLG	DEG_APCC_DBOX_1	0.1667
p.E32Q	ACH-000861	Lung Cancer	CCLE	ARHGLQSLG	DEG_APCC_DBOX_1	0.1667
p.E32Q	HOP-62	lung	COSMIC	ARHGLQSLG	DEG_APCC_DBOX_1	0.1667
p.L42F	HSC-3	upper_aerodigestive_tract	COSMIC	ARHGLQSLG	DEG_APCC_DBOX_1	0.6981
p.E47Q	CAL-148	breast	COSMIC	ARHGLQSLG	DEG_APCC_DBOX_1	0.75
p.R50H	DG-75	haematopoietic_and_lymphoid_tissue	COSMIC	ARHGLQSLG	DEG_APCC_DBOX_1	0.2222
p.L44F	HSC-3	upper_aerodigestive_tract	COSMIC	ARHGLQSLG	DEG_APCC_DBOX_1	0.6981

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ARHGLQSLG

Degron related mutations and impact score

Drug responses associated with PRRC2C mutations

All proteins holding degron of ARHGLQSLG

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y520	Protein PRRC2C	DEG_APCC_DBOX_1	38:46	ARHGLQSLG	APC,CDC20,FZR1	0.9747	More...