DegronMD

Uniprot ID: Q9Y520

Source protein: Protein PRRC2C

Source gene: PRRC2C

Class: DEG_SCF_FBW7_1

Location: 2309:2314

E3 ligase: FBXW7

DEGRON score: 0.9953

ASA_SCORE: 83.6167

COIL: 0.951

CONS_SCORE: 0.5467

DSS_SCORE: 0.401

HELIX: 0.0255

FCONS_SCORE: 1.0435

RIG_SCORE: 0.7123

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T2312A	TCGA-78-7539	LUAD	TCGA	VTPTAS	DEG_SCF_FBW7_1	0.6028
p.G2319C	TCGA-D3-A3CE	SKCM	TCGA	VTPTAS	DEG_SCF_FBW7_1	0.1944
p.G2319C	TCGA-FS-A1ZN	SKCM	TCGA	VTPTAS	DEG_SCF_FBW7_1	0.1944
p.A2309S	DO229035	LICA	ICGC	VTPTAS	DEG_SCF_FBW7_1	0.7588
p.A2320T	DO48719	LIRI	ICGC	VTPTAS	DEG_SCF_FBW7_1	0.1667
p.T2314A	DO26210	LUAD	ICGC	VTPTAS	DEG_SCF_FBW7_1	0.7139
p.G2321C	DO37405	SKCM	ICGC	VTPTAS	DEG_SCF_FBW7_1	0.5833
p.G2321C	DO38165	SKCM	ICGC	VTPTAS	DEG_SCF_FBW7_1	0.5833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y520	Protein PRRC2C	DEG_SCF_FBW7_1	2309:2314	VTPTAS	FBXW7	0.9953	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons