DegronMD

Uniprot ID: P22736

Source protein: Nuclear receptor subfamily 4 group A member 1

Source gene: NR4A1

Class: DEG_SCF_FBW7_1

Location: 245:252

E3 ligase: FBXW7

DEGRON score: 0.9969

ASA_SCORE: 92.4625

COIL: 0.9504

CONS_SCORE: 0.418

DSS_SCORE: 0.6117

HELIX: 0.0143

FCONS_SCORE: 1.043

RIG_SCORE: 0.732

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D260N	TCGA-KL-8326	KICH	TCGA	ILDTPVTS	DEG_SCF_FBW7_1	0.1111
p.D260N	DO220334	KICH	ICGC	ILDTPVTS	DEG_SCF_FBW7_1	0.1111
p.A247P	TCGA-L5-A4OX	ESCA	TCGA	ILDTPVTS	DEG_SCF_FBW7_1	0.7503
p.A247E	TCGA-L5-A4OX	ESCA	TCGA	ILDTPVTS	DEG_SCF_FBW7_1	0.7701
p.P240S	DO50454	ESAD	ICGC	ILDTPVTS	DEG_SCF_FBW7_1	0.1944
p.P240S	SIDM00032	Bladder Carcinoma	GDSC	ILDTPVTS	DEG_SCF_FBW7_1	0.1944
p.G261C	DO228986	LICA	ICGC	ILDTPVTS	DEG_SCF_FBW7_1	0.0833
p.P251L	DO229465	SKCA	ICGC	ILDTPVTS	DEG_SCF_FBW7_1	0.7582
p.S255T	SIDM00345	Non-Small Cell Lung Carcinoma	GDSC	ILDTPVTS	DEG_SCF_FBW7_1	0.25
p.S255T	LCLC-103H	lung	COSMIC	ILDTPVTS	DEG_SCF_FBW7_1	0.25
p.P252R	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	ILDTPVTS	DEG_SCF_FBW7_1	0.7512
p.P252R	NCI-H2342	lung	COSMIC	ILDTPVTS	DEG_SCF_FBW7_1	0.7512
p.R256Q	ACH-000939	Sarcoma	CCLE	ILDTPVTS	DEG_SCF_FBW7_1	0.2222
p.R256Q	ACH-000997	Colon/Colorectal Cancer	CCLE	ILDTPVTS	DEG_SCF_FBW7_1	0.2222
p.R256Q	ACH-001061	Colon/Colorectal Cancer	CCLE	ILDTPVTS	DEG_SCF_FBW7_1	0.2222
p.R256Q	SK-UT-1	soft_tissue	COSMIC	ILDTPVTS	DEG_SCF_FBW7_1	0.2222
p.R256Q	HCT-15	large_intestine	COSMIC	ILDTPVTS	DEG_SCF_FBW7_1	0.2222
p.H239Y	ACH-001378	Pancreatic Cancer	CCLE	ILDTPVTS	DEG_SCF_FBW7_1	0.1667
p.I245V	ACH-001707	Leukemia	CCLE	ILDTPVTS	DEG_SCF_FBW7_1	0.5965
p.S238Y	SNU-1040	large_intestine	COSMIC	ILDTPVTS	DEG_SCF_FBW7_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P22736	Nuclear receptor subfamily 4 group A member 1	DEG_SCF_FBW7_1	245:252	ILDTPVTS	FBXW7	0.9969	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons