DegronMD - Q01804(OTUD4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R359G	TCGA-22-4591	LUSC	TCGA	DYR	CBL_MET	360:362	Mutation rewiring degron network	0.3056
p.P658S	TCGA-32-2634	GBM	TCGA	LSLYQD	LIG_APCC_ABBA_1	658:663	Mutation altering degron motif	0.6752
p.D239V	TCGA-66-2763	LUSC	TCGA	SRKVLKSLN	DEG_APCC_DBOX_1	244:252	Mutation rewiring degron network	0.1944
p.D239V	DO27620	LUSC	ICGC	SRKVLKSLN	DEG_APCC_DBOX_1	244:252	Mutation rewiring degron network	0.1944
p.R361S	TCGA-AA-3715	COAD	TCGA	DYR	CBL_MET	360:362	Mutation altering degron motif	0.7427
p.K234Q	TCGA-AA-3984	COAD	TCGA	SRKVLKSLN	DEG_APCC_DBOX_1	244:252	Mutation rewiring degron network	0.0556
p.K234Q	DO9002	COAD	ICGC	SRKVLKSLN	DEG_APCC_DBOX_1	244:252	Mutation rewiring degron network	0.0556
p.Y670H	TCGA-AD-A5EJ	COAD	TCGA	LSLYQD	LIG_APCC_ABBA_1	658:663	Mutation rewiring degron network	0.1389
p.R361I	TCGA-AP-A059	UCEC	TCGA	DYR	CBL_MET	360:362	Mutation altering degron motif	0.8102
p.R361I	TCGA-EO-A22R	UCEC	TCGA	DYR	CBL_MET	360:362	Mutation altering degron motif	0.8102
p.R361I	DO42713	UCEC	ICGC	DYR	CBL_MET	360:362	Mutation altering degron motif	0.8102
p.R361I	DO41361	UCEC	ICGC	DYR	CBL_MET	360:362	Mutation altering degron motif	0.8102
p.R361I	SIDM00193	Colorectal Carcinoma	GDSC	DYR	CBL_MET	360:362	Mutation altering degron motif	0.8102
p.R361I	SNU-81	large intestine	COSMIC	DYR	CBL_MET	360:362	Mutation altering degron motif	0.8102
p.K262N	TCGA-AP-A0LM	UCEC	TCGA	SRKVLKSLN	DEG_APCC_DBOX_1	244:252	Mutation rewiring degron network	0.0556
p.K262N	TCGA-CG-4442	STAD	TCGA	SRKVLKSLN	DEG_APCC_DBOX_1	244:252	Mutation rewiring degron network	0.0556
p.K262N	DO38380	STAD	ICGC	SRKVLKSLN	DEG_APCC_DBOX_1	244:252	Mutation rewiring degron network	0.0556
p.K262N	DO43306	UCEC	ICGC	SRKVLKSLN	DEG_APCC_DBOX_1	244:252	Mutation rewiring degron network	0.0556
p.R462I	TCGA-B5-A1MR	UCEC	TCGA	ALSSS	DEG_SPOP_SBC_1	472:476	Mutation rewiring degron network	0.0556
p.R361K	TCGA-B5-A3FC	UCEC	TCGA	DYR	CBL_MET	360:362	Mutation altering degron motif	0.7237
p.R361K	DO41871	UCEC	ICGC	DYR	CBL_MET	360:362	Mutation altering degron motif	0.7237
p.W650L	TCGA-BF-A1PU	SKCM	TCGA	LSLYQD	LIG_APCC_ABBA_1	658:663	Mutation rewiring degron network	0.1111
p.W650L	TCGA-D3-A2JP	SKCM	TCGA	LSLYQD	LIG_APCC_ABBA_1	658:663	Mutation rewiring degron network	0.1111
p.H367Y	TCGA-BH-A1F8	BRCA	TCGA	DYR	CBL_MET	360:362	Mutation rewiring degron network	0.1944
p.R370Q	TCGA-BK-A6W3	UCEC	TCGA	DYR	CBL_MET	360:362	Mutation rewiring degron network	0.1111
p.R361T	TCGA-CI-6621	READ	TCGA	DYR	CBL_MET	360:362	Mutation altering degron motif	0.7876
p.K486N	TCGA-EO-A22R	UCEC	TCGA	ALSSS	DEG_SPOP_SBC_1	472:476	Mutation rewiring degron network	0.0556
p.K486N	SIDM00210	Ovarian Carcinoma	GDSC	ALSSS	DEG_SPOP_SBC_1	472:476	Mutation rewiring degron network	0.0556
p.K486N	SIDM01112	Osteosarcoma	GDSC	ALSSS	DEG_SPOP_SBC_1	472:476	Mutation rewiring degron network	0.0556
p.K486N	SIDM01588	Endometrial Carcinoma	GDSC	ALSSS	DEG_SPOP_SBC_1	472:476	Mutation rewiring degron network	0.0556
p.K234T	TCGA-EO-A22X	UCEC	TCGA	SRKVLKSLN	DEG_APCC_DBOX_1	244:252	Mutation rewiring degron network	0.0556
p.K234T	DO43907	UCEC	ICGC	SRKVLKSLN	DEG_APCC_DBOX_1	244:252	Mutation rewiring degron network	0.0556
p.P249Q	TCGA-ER-A19P	SKCM	TCGA	SRKVLKSLN	DEG_APCC_DBOX_1	244:252	Mutation altering degron motif	0.7035
p.P249Q	DO47623	SKCM	ICGC	SRKVLKSLN	DEG_APCC_DBOX_1	244:252	Mutation altering degron motif	0.7035
p.S372F	TCGA-FS-A1ZK	SKCM	TCGA	DYR	CBL_MET	360:362	Mutation substituting flanking lysine	0.1667
p.Q241K	TCGA-KQ-A41N	BLCA	TCGA	SRKVLKSLN	DEG_APCC_DBOX_1	244:252	Mutation rewiring degron network	0.25
p.Q241K	DO223588	BLCA	ICGC	SRKVLKSLN	DEG_APCC_DBOX_1	244:252	Mutation rewiring degron network	0.25
p.S480L	TCGA-L5-A4OJ	ESCA	TCGA	ALSSS	DEG_SPOP_SBC_1	472:476	Mutation rewiring degron network	0.2222
p.L664M	TCGA-MB-A5Y8	SARC	TCGA	LSLYQD	LIG_APCC_ABBA_1	658:663	Mutation rewiring degron network	0.3056
p.S481L	DO49976	CESC	ICGC	ALSSS	DEG_SPOP_SBC_1	472:476	Mutation rewiring degron network	0.1944
p.A469T	DO8103	COAD	ICGC	ALSSS	DEG_SPOP_SBC_1	472:476	Mutation rewiring degron network	0.25
p.K365N	DO8842	COAD	ICGC	DYR	CBL_MET	360:362	Mutation substituting flanking lysine	0.3611
p.K365N	DO43907	UCEC	ICGC	DYR	CBL_MET	360:362	Mutation substituting flanking lysine	0.3611
p.S486R	DO50654	KIRC	ICGC	ALSSS	DEG_SPOP_SBC_1	472:476	Mutation rewiring degron network	0.0556
p.P650L	DO229054	LICA	ICGC	LSLYQD	LIG_APCC_ABBA_1	658:663	Mutation rewiring degron network	0.1111
p.I371T	DO50911	LICA	ICGC	DYR	CBL_MET	360:362	Mutation rewiring degron network	0.0833
p.S476L	DO50727	ORCA	ICGC	ALSSS	DEG_SPOP_SBC_1	472:476	Mutation altering degron motif	0.7667
p.P667S	DO37603	SKCM	ICGC	LSLYQD	LIG_APCC_ABBA_1	658:663	Mutation rewiring degron network	0.2222
p.S474Y	DO47578	SKCM	ICGC	ALSSS	DEG_SPOP_SBC_1	472:476	Mutation altering degron motif	0.712
p.A482D	DO38404	STAD	ICGC	ALSSS	DEG_SPOP_SBC_1	472:476	Mutation rewiring degron network	0.1667
p.P370S	DO47819	STAD	ICGC	DYR	CBL_MET	360:362	Mutation rewiring degron network	0.1111
p.G363E	DO41752	UCEC	ICGC	DYR	CBL_MET	360:362	Mutation rewiring degron network	0.3056
p.K372Q	DO42400	UCEC	ICGC	DYR	CBL_MET	360:362	Mutation substituting flanking lysine	0.1667
p.D466G	DO42713	UCEC	ICGC	ALSSS	DEG_SPOP_SBC_1	472:476	Mutation rewiring degron network	0.1667
p.K486Q	SIDM00661	B-Cell Non-Hodgkin's Lymphoma	GDSC	ALSSS	DEG_SPOP_SBC_1	472:476	Mutation rewiring degron network	0.0556
p.K486Q	HT	haematopoietic and lymphoid tissue	COSMIC	ALSSS	DEG_SPOP_SBC_1	472:476	Mutation rewiring degron network	0.0556
p.V252A	SIDM00586	Hepatocellular Carcinoma	GDSC	SRKVLKSLN	DEG_APCC_DBOX_1	244:252	Mutation altering degron motif	0.6936
p.V252A	SIDM00571	Pancreatic Carcinoma	GDSC	SRKVLKSLN	DEG_APCC_DBOX_1	244:252	Mutation altering degron motif	0.6936
p.V252A	SIDM00618	Hepatocellular Carcinoma	GDSC	SRKVLKSLN	DEG_APCC_DBOX_1	244:252	Mutation altering degron motif	0.6936
p.V252A	SIDM00591	Oral Cavity Carcinoma	GDSC	SRKVLKSLN	DEG_APCC_DBOX_1	244:252	Mutation altering degron motif	0.6936
p.V252A	SIDM01659	Kidney Carcinoma	GDSC	SRKVLKSLN	DEG_APCC_DBOX_1	244:252	Mutation altering degron motif	0.6936
p.V252A	SIDM01320	Pancreatic Carcinoma	GDSC	SRKVLKSLN	DEG_APCC_DBOX_1	244:252	Mutation altering degron motif	0.6936
p.V252A	JHH-1	liver	COSMIC	SRKVLKSLN	DEG_APCC_DBOX_1	244:252	Mutation altering degron motif	0.6936
p.V252A	HO-1-u-1	upper aerodigestive tract	COSMIC	SRKVLKSLN	DEG_APCC_DBOX_1	244:252	Mutation altering degron motif	0.6936
p.V252A	KP-3	pancreas	COSMIC	SRKVLKSLN	DEG_APCC_DBOX_1	244:252	Mutation altering degron motif	0.6936
p.V252A	huH-1	liver	COSMIC	SRKVLKSLN	DEG_APCC_DBOX_1	244:252	Mutation altering degron motif	0.6936
p.D364N	SIDM00922	Non-Small Cell Lung Carcinoma	GDSC	DYR	CBL_MET	360:362	Mutation rewiring degron network	0.2778
p.D364N	Calu-3	lung	COSMIC	DYR	CBL_MET	360:362	Mutation rewiring degron network	0.2778
p.E464K	SIDM00193	Colorectal Carcinoma	GDSC	ALSSS	DEG_SPOP_SBC_1	472:476	Mutation rewiring degron network	0.1111
p.E464K	SNU-81	large intestine	COSMIC	ALSSS	DEG_SPOP_SBC_1	472:476	Mutation rewiring degron network	0.1111
p.Y655H	SIDM01154	T-Lymphoblastic Leukemia	GDSC	LSLYQD	LIG_APCC_ABBA_1	658:663	Mutation rewiring degron network	0.25
p.Y655H	SUP-T1	haematopoietic and lymphoid tissue	COSMIC	LSLYQD	LIG_APCC_ABBA_1	658:663	Mutation rewiring degron network	0.25
p.L659V	SIDM00892	Breast Carcinoma	GDSC	LSLYQD	LIG_APCC_ABBA_1	658:663	Mutation altering degron motif	0.6765
p.L659V	BT-483	breast	COSMIC	LSLYQD	LIG_APCC_ABBA_1	658:663	Mutation altering degron motif	0.6765
p.S369R	SIDM01611	Endometrial Carcinoma	GDSC	DYR	CBL_MET	360:362	Mutation substituting flanking lysine	0.25
p.K475T	SIDM01588	Endometrial Carcinoma	GDSC	ALSSS	DEG_SPOP_SBC_1	472:476	Mutation altering degron motif	0.7306
p.V478A	ACH-000347	Pancreatic Cancer	CCLE	ALSSS	DEG_SPOP_SBC_1	472:476	Mutation rewiring degron network	0.2778
p.V478A	QGP-1	pancreas	COSMIC	ALSSS	DEG_SPOP_SBC_1	472:476	Mutation rewiring degron network	0.2778
p.A482T	ACH-000602	Leukemia	CCLE	ALSSS	DEG_SPOP_SBC_1	472:476	Mutation rewiring degron network	0.1667
p.S244F	ACH-000689	Sarcoma	CCLE	SRKVLKSLN	DEG_APCC_DBOX_1	244:252	Mutation altering degron motif	0.6871
p.S244F	RH-18	soft tissue	COSMIC	SRKVLKSLN	DEG_APCC_DBOX_1	244:252	Mutation altering degron motif	0.6871

DegronMD: protein-targeted degradation, mutation and drug response to degrons

OTUD4

UniProt ID: Q01804

Entrez ID: 54726

Protein name: OTU domain-containing protein 4 (EC 3.4.19.12) (HIV-1-induced protein HIN-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for OTUD4 in