DegronMD

Uniprot ID: Q01804

Source protein: OTU domain-containing protein 4

Source gene: OTUD4

Class: LIG_APCC_ABBA_1

Location: 658:663

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9162

ASA_SCORE: 62.3167

COIL: 0.8383

CONS_SCORE: 0.3831

DSS_SCORE: 0.3204

HELIX: 0.087

FCONS_SCORE: 0.7717

RIG_SCORE: 0.7991

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P658S	TCGA-32-2634	GBM	TCGA	LSLYQD	LIG_APCC_ABBA_1	0.6752
p.Y670H	TCGA-AD-A5EJ	COAD	TCGA	LSLYQD	LIG_APCC_ABBA_1	0.1389
p.W650L	TCGA-BF-A1PU	SKCM	TCGA	LSLYQD	LIG_APCC_ABBA_1	0.1111
p.W650L	TCGA-D3-A2JP	SKCM	TCGA	LSLYQD	LIG_APCC_ABBA_1	0.1111
p.L664M	TCGA-MB-A5Y8	SARC	TCGA	LSLYQD	LIG_APCC_ABBA_1	0.3056
p.P650L	DO229054	LICA	ICGC	LSLYQD	LIG_APCC_ABBA_1	0.1111
p.P667S	DO37603	SKCM	ICGC	LSLYQD	LIG_APCC_ABBA_1	0.2222
p.Y655H	SIDM01154	T-Lymphoblastic Leukemia	GDSC	LSLYQD	LIG_APCC_ABBA_1	0.25
p.Y655H	SUP-T1	haematopoietic_and_lymphoid_tissue	COSMIC	LSLYQD	LIG_APCC_ABBA_1	0.25
p.L659V	SIDM00892	Breast Carcinoma	GDSC	LSLYQD	LIG_APCC_ABBA_1	0.6765
p.L659V	BT-483	breast	COSMIC	LSLYQD	LIG_APCC_ABBA_1	0.6765

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q01804	OTU domain-containing protein 4	LIG_APCC_ABBA_1	658:663	LSLYQD	APC,CDC20,FZR1	0.9162	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons