DegronMD

Uniprot ID: Q01804

Source protein: OTU domain-containing protein 4

Source gene: OTUD4

Class: DEG_APCC_DBOX_1

Location: 244:252

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6595

ASA_SCORE: 59.8889

COIL: 0.4254

CONS_SCORE: 0.6473

DSS_SCORE: 0.3024

HELIX: 0.5661

FCONS_SCORE: 1.2442

RIG_SCORE: 0.7848

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D239V	TCGA-66-2763	LUSC	TCGA	SRKVLKSLN	DEG_APCC_DBOX_1	0.1944
p.D239V	DO27620	LUSC	ICGC	SRKVLKSLN	DEG_APCC_DBOX_1	0.1944
p.K234Q	TCGA-AA-3984	COAD	TCGA	SRKVLKSLN	DEG_APCC_DBOX_1	0.0556
p.K234Q	DO9002	COAD	ICGC	SRKVLKSLN	DEG_APCC_DBOX_1	0.0556
p.K262N	TCGA-AP-A0LM	UCEC	TCGA	SRKVLKSLN	DEG_APCC_DBOX_1	0.0556
p.K262N	TCGA-CG-4442	STAD	TCGA	SRKVLKSLN	DEG_APCC_DBOX_1	0.0556
p.K262N	DO38380	STAD	ICGC	SRKVLKSLN	DEG_APCC_DBOX_1	0.0556
p.K262N	DO43306	UCEC	ICGC	SRKVLKSLN	DEG_APCC_DBOX_1	0.0556
p.K234T	TCGA-EO-A22X	UCEC	TCGA	SRKVLKSLN	DEG_APCC_DBOX_1	0.0556
p.K234T	DO43907	UCEC	ICGC	SRKVLKSLN	DEG_APCC_DBOX_1	0.0556
p.P249Q	TCGA-ER-A19P	SKCM	TCGA	SRKVLKSLN	DEG_APCC_DBOX_1	0.7035
p.P249Q	DO47623	SKCM	ICGC	SRKVLKSLN	DEG_APCC_DBOX_1	0.7035
p.Q241K	TCGA-KQ-A41N	BLCA	TCGA	SRKVLKSLN	DEG_APCC_DBOX_1	0.25
p.Q241K	DO223588	BLCA	ICGC	SRKVLKSLN	DEG_APCC_DBOX_1	0.25
p.V252A	SIDM00586	Hepatocellular Carcinoma	GDSC	SRKVLKSLN	DEG_APCC_DBOX_1	0.6936
p.V252A	SIDM00571	Pancreatic Carcinoma	GDSC	SRKVLKSLN	DEG_APCC_DBOX_1	0.6936
p.V252A	SIDM00618	Hepatocellular Carcinoma	GDSC	SRKVLKSLN	DEG_APCC_DBOX_1	0.6936
p.V252A	SIDM00591	Oral Cavity Carcinoma	GDSC	SRKVLKSLN	DEG_APCC_DBOX_1	0.6936
p.V252A	SIDM01659	Kidney Carcinoma	GDSC	SRKVLKSLN	DEG_APCC_DBOX_1	0.6936
p.V252A	SIDM01320	Pancreatic Carcinoma	GDSC	SRKVLKSLN	DEG_APCC_DBOX_1	0.6936
p.V252A	JHH-1	liver	COSMIC	SRKVLKSLN	DEG_APCC_DBOX_1	0.6936
p.V252A	HO-1-u-1	upper_aerodigestive_tract	COSMIC	SRKVLKSLN	DEG_APCC_DBOX_1	0.6936
p.V252A	KP-3	pancreas	COSMIC	SRKVLKSLN	DEG_APCC_DBOX_1	0.6936
p.V252A	huH-1	liver	COSMIC	SRKVLKSLN	DEG_APCC_DBOX_1	0.6936
p.S244F	ACH-000689	Sarcoma	CCLE	SRKVLKSLN	DEG_APCC_DBOX_1	0.6871
p.S244F	RH-18	soft_tissue	COSMIC	SRKVLKSLN	DEG_APCC_DBOX_1	0.6871

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q01804	OTU domain-containing protein 4	DEG_APCC_DBOX_1	244:252	SRKVLKSLN	APC,CDC20,FZR1	0.6595	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SRKVLKSLN

Degron related mutations and impact score

Drug responses associated with OTUD4 mutations

All proteins holding degron of SRKVLKSLN