DegronMD - Q8NEJ9(NGDN)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V177F	TCGA-66-2791	LUSC	TCGA	VPVHYD	LIG_APCC_ABBA_1	177:182	Mutation altering degron motif	0.5957
p.V177F	DO26435	LUSC	ICGC	VPVHYD	LIG_APCC_ABBA_1	177:182	Mutation altering degron motif	0.5957
p.R188P	TCGA-67-3771	LUAD	TCGA	VPVHYD	LIG_APCC_ABBA_1	177:182	Mutation rewiring degron network	0.1667
p.R188P	DO25797	LUAD	ICGC	VPVHYD	LIG_APCC_ABBA_1	177:182	Mutation rewiring degron network	0.1667
p.R175H	TCGA-AJ-A3EL	UCEC	TCGA	VPVHYD	LIG_APCC_ABBA_1	177:182	Mutation rewiring degron network	0.2778
p.R175H	DO41542	UCEC	ICGC	VPVHYD	LIG_APCC_ABBA_1	177:182	Mutation rewiring degron network	0.2778
p.R199W	TCGA-AP-A1DO	UCEC	TCGA	ALSSS	DEG_SPOP_SBC_1	200:204	Mutation rewiring degron network	0.3056
p.R199W	DO43250	UCEC	ICGC	ALSSS	DEG_SPOP_SBC_1	200:204	Mutation rewiring degron network	0.3056
p.K169N	TCGA-B5-A1MR	UCEC	TCGA	VPVHYD	LIG_APCC_ABBA_1	177:182	Mutation substituting flanking lysine	0.2222
p.K169N	TCGA-EO-A22U	UCEC	TCGA	VPVHYD	LIG_APCC_ABBA_1	177:182	Mutation substituting flanking lysine	0.2222
p.K169N	TCGA-EO-A3B0	UCEC	TCGA	VPVHYD	LIG_APCC_ABBA_1	177:182	Mutation substituting flanking lysine	0.2222
p.K169N	DO219773	UCEC	ICGC	VPVHYD	LIG_APCC_ABBA_1	177:182	Mutation substituting flanking lysine	0.2222
p.K169N	DO41758	UCEC	ICGC	VPVHYD	LIG_APCC_ABBA_1	177:182	Mutation substituting flanking lysine	0.2222
p.K169N	DO43755	UCEC	ICGC	VPVHYD	LIG_APCC_ABBA_1	177:182	Mutation substituting flanking lysine	0.2222
p.I206F	TCGA-LA-A446	LUSC	TCGA	ALSSS	DEG_SPOP_SBC_1	200:204	Mutation rewiring degron network	0.2778
p.I206F	DO45450	LUSC	ICGC	ALSSS	DEG_SPOP_SBC_1	200:204	Mutation rewiring degron network	0.2778
p.R207H	TCGA-VQ-A8DT	STAD	TCGA	ALSSS	DEG_SPOP_SBC_1	200:204	Mutation rewiring degron network	0.25
p.R207H	DO51751	STAD	ICGC	ALSSS	DEG_SPOP_SBC_1	200:204	Mutation rewiring degron network	0.25
p.H180Y	DO233764	GACA	ICGC	VPVHYD	LIG_APCC_ABBA_1	177:182	Mutation altering degron motif	0.6118
p.E189D	DO228900	LICA	ICGC	VPVHYD	LIG_APCC_ABBA_1	177:182	Mutation rewiring degron network	0.1389
p.E189D	DO229019	LICA	ICGC	VPVHYD	LIG_APCC_ABBA_1	177:182	Mutation rewiring degron network	0.1389
p.V172F	DO229035	LICA	ICGC	VPVHYD	LIG_APCC_ABBA_1	177:182	Mutation rewiring degron network	0.1944
p.V167L	DO229038	LICA	ICGC	VPVHYD	LIG_APCC_ABBA_1	177:182	Mutation rewiring degron network	0.0556
p.D182Y	DO229037	LICA	ICGC	VPVHYD	LIG_APCC_ABBA_1	177:182	Mutation altering degron motif	0.7325
p.V179I	SIDM00460	B-Cell Non-Hodgkin's Lymphoma	GDSC	VPVHYD	LIG_APCC_ABBA_1	177:182	Mutation altering degron motif	0.5965
p.V179I	ACH-000124	Lymphoma	CCLE	VPVHYD	LIG_APCC_ABBA_1	177:182	Mutation altering degron motif	0.5965
p.V179I	OCI-LY-19	haematopoietic and lymphoid tissue	COSMIC	VPVHYD	LIG_APCC_ABBA_1	177:182	Mutation altering degron motif	0.5965
p.R207C	SIDM01041	Esophageal Carcinoma	GDSC	ALSSS	DEG_SPOP_SBC_1	200:204	Mutation rewiring degron network	0.25
p.R207C	ACH-001500	Esophageal Cancer	CCLE	ALSSS	DEG_SPOP_SBC_1	200:204	Mutation rewiring degron network	0.25
p.R207C	FLO-1	oesophagus	COSMIC	ALSSS	DEG_SPOP_SBC_1	200:204	Mutation rewiring degron network	0.25
p.R175C	SIDM00596	Endometrial Carcinoma	GDSC	VPVHYD	LIG_APCC_ABBA_1	177:182	Mutation rewiring degron network	0.2778
p.R175C	ACH-001517	Endometrial/Uterine Cancer	CCLE	VPVHYD	LIG_APCC_ABBA_1	177:182	Mutation rewiring degron network	0.2778
p.R175C	HEC-1	endometrium	COSMIC	VPVHYD	LIG_APCC_ABBA_1	177:182	Mutation rewiring degron network	0.2778
p.E185Q	SIDM01645	Non-Cancerous	GDSC	VPVHYD	LIG_APCC_ABBA_1	177:182	Mutation rewiring degron network	0.25

Kaplan plot for NGDN in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NGDN

UniProt ID: Q8NEJ9

Entrez ID: 25983

Protein name: Neuroguidin (Centromere accumulated nuclear protein 1) (CANu1) (EIF4E-binding protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NGDN in